OpenLB
Open Library of Bioscience
Advanced Search
Clinical kidney journal
Mar, 2021;14 (3): 756-767.

A primer on metabolic memory: why existing diabesity treatments fail.

Sidar Copur, Peter Rossing, Baris Afsar, Alan A Sag, Dimitrie Siriopol, Masanari Kuwabara, Alberto Ortiz, Mehmet Kanbay
Author Information
  1. Sidar Copur: Department of Medicine, Koc University School of Medicine, Istanbul, Turkey.
  2. Peter Rossing: Steno Diabetes Center Copenhagen, University of Copenhagen, Copenhagen, Denmark.
  3. Baris Afsar: Department of Internal Medicine, Division of Nephrology, Suleyman Demirel University School of Medicine, Isparta, Turkey.
  4. Alan A Sag: Department of Radiology, Division of Vascular and Interventional Radiology, Duke University Medical Center, Durham, NC, USA.
  5. Dimitrie Siriopol: Nephrology Clinic, Dialysis and Renal Transplant Center, 'C.I. PARHON' University Hospital, 'Grigore T. Popa' University of Medicine, Iasi, Romania.
  6. Masanari Kuwabara: Department of Cardiology, Toranomon Hospital, Tokyo, Japan.
  7. Alberto Ortiz: School of Medicine, Dialysis Unit, IIS-Fundacion Jimenez Diaz, Universidad Autónoma de Madrid, Madrid, Spain.
  8. Mehmet Kanbay: Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey. ORCID
PMID: 34512957 DOI: 10.1093/ckj/sfaa143

Abstract

Despite massive government and private sector investments into prevention of cardiovascular disease, diabetes mellitus and obesity, efforts have largely failed, and the burden of cost remains in the treatment of downstream morbidity and mortality, with overall stagnating outcomes. A new paradigm shift in the approach to these patients may explain why existing treatment strategies fail, and offer new treatment targets. This review aims to provide a clinician-centred primer on metabolic memory, defined as the sum of irreversible genetic, epigenetic, cellular and tissue-level alterations that occur with long-time exposure to metabolic derangements.

Keywords

chronic kidney disease diabetic kidney disease epigenetics metabolic memory sirtuin 1

References

  1. Nat Rev Drug Discov. 2012 Apr 13;11(5):384-400 [PMID: 22498752]
  2. Iran J Basic Med Sci. 2015 Oct;18(10):1020-6 [PMID: 26730338]
  3. Clin Sci (Lond). 2010 Apr 20;119(2):87-95 [PMID: 20218970]
  4. Science. 2009 Dec 11;326(5959):1509-12 [PMID: 19933107]
  5. N Engl J Med. 1993 Sep 30;329(14):977-86 [PMID: 8366922]
  6. Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17046-9 [PMID: 18955703]
  7. Nat Cell Biol. 2009 Jul;11(7):881-9 [PMID: 19543271]
  8. PLoS One. 2012;7(8):e43584 [PMID: 22912891]
  9. Diabetes. 2013 Sep;62(9):3151-62 [PMID: 23649518]
  10. Genes Dev. 2011 Sep 15;25(18):1915-27 [PMID: 21890647]
  11. Sci Signal. 2013 Jun 04;6(278):ra43 [PMID: 23737551]
  12. J Am Soc Nephrol. 2017 Feb;28(2):479-493 [PMID: 27444565]
  13. J Am Soc Nephrol. 2017 Oct;28(10):2985-2992 [PMID: 28663230]
  14. PLoS One. 2015 Aug 10;10(8):e0134654 [PMID: 26258530]
  15. J Biol Chem. 2013 Aug 2;288(31):22469-80 [PMID: 23788640]
  16. Nat Commun. 2017 Nov 13;8(1):1467 [PMID: 29133788]
  17. Trends Cell Biol. 2011 Jun;21(6):354-61 [PMID: 21550244]
  18. Cell Physiol Biochem. 2015;35(5):1986-98 [PMID: 25871510]
  19. J Am Soc Nephrol. 2008 Jul;19(7):1311-20 [PMID: 18322163]
  20. Interdiscip Top Gerontol. 2015;40:99-106 [PMID: 25341516]
  21. Diabetes. 2012 May;61(5):1272-80 [PMID: 22396200]
  22. Semin Nephrol. 2013 Jul;33(4):375-82 [PMID: 24011579]
  23. Clin Epigenetics. 2015 Aug 05;7:79 [PMID: 26244062]
  24. FASEB J. 1999 Jan;13(1):23-30 [PMID: 9872926]
  25. Lancet. 2017 Sep 16;390(10100):1151-1210 [PMID: 28919116]
  26. Diabetes Care. 2016 May;39(5):686-93 [PMID: 26861924]
  27. N Engl J Med. 2005 Dec 22;353(25):2643-53 [PMID: 16371630]
  28. Cell Death Differ. 2016 Aug;23(8):1394-405 [PMID: 27258785]
  29. EMBO Mol Med. 2012 Nov;4(11):1176-85 [PMID: 23023917]
  30. Diabetes. 1994 Mar;43(3):478-90 [PMID: 8314022]
  31. J Clin Invest. 1995 Sep;96(3):1395-403 [PMID: 7544803]
  32. DNA Cell Biol. 2007 Aug;26(8):603-11 [PMID: 17688412]
  33. BMJ. 1997 Nov 22;315(7119):1342-8 [PMID: 9402775]
  34. Nature. 2000 Apr 13;404(6779):787-90 [PMID: 10783895]
  35. FEBS Lett. 2010 Feb 19;584(4):811-6 [PMID: 20067797]
  36. Diabetes. 2013 Apr;62(4):1320-8 [PMID: 23209187]
  37. Toxicol Lett. 2012 Sep 3;213(2):228-34 [PMID: 22728133]
  38. Discov Med. 2018 Feb;25(136):57-65 [PMID: 29579412]
  39. Mol Endocrinol. 2014 Aug;28(8):1211-20 [PMID: 24911120]
  40. JAMA. 2003 Oct 22;290(16):2159-67 [PMID: 14570951]
  41. Mol Med. 1995 May;1(4):447-56 [PMID: 8521302]
  42. Mob DNA. 2014 Mar 03;5(1):7 [PMID: 24589358]
  43. Circ Res. 2007 Mar 2;100(4):520-6 [PMID: 17255528]
  44. PLoS One. 2013 Sep 13;8(9):e73950 [PMID: 24058506]
  45. Am J Physiol Heart Circ Physiol. 2007 Aug;293(2):H968-77 [PMID: 17400721]
  46. Immunol Cell Biol. 2010 Jul;88(5):555-64 [PMID: 20195282]
  47. Ageing Res Rev. 2018 Jan;41:1-17 [PMID: 29081381]
  48. Nature. 2012 Feb 15;482(7385):331-8 [PMID: 22337052]
  49. Diabetes. 2014 May;63(5):1748-62 [PMID: 24458354]
  50. Diabetologia. 2001 Sep;44(9):1133-9 [PMID: 11596668]
  51. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3432-7 [PMID: 17360662]
  52. Nat Struct Mol Biol. 2013 Dec;20(12):1458-64 [PMID: 24213537]
  53. Heart Fail Rev. 2015 May;20(3):259-72 [PMID: 25344016]
  54. Diabetes. 1999 Apr;48(4):855-64 [PMID: 10102704]
  55. Vascul Pharmacol. 2019 Mar;114:139-144 [PMID: 29398367]
  56. Nat Rev Immunol. 2009 Feb;9(2):83-9 [PMID: 19114986]
  57. Nat Rev Nephrol. 2016 Feb;12(2):73-81 [PMID: 26553517]
  58. J Clin Invest. 2004 Dec;114(12):1741-51 [PMID: 15599399]
  59. Nat Rev Genet. 2010 Mar;11(3):181-90 [PMID: 20125085]
  60. Lancet Glob Health. 2013 Dec;1(6):e339-49 [PMID: 25104599]
  61. J Immunol. 2016 Oct 15;197(8):3076-3085 [PMID: 27655844]
  62. Diabetologia. 1994 Aug;37(8):838-41 [PMID: 7988787]
  63. Br J Haematol. 1996 Mar;92(3):747-50 [PMID: 8616048]
  64. Diabetes. 2018 May;67(5):1013-1023 [PMID: 29453204]
  65. Cell Metab. 2012 Oct 3;16(4):435-48 [PMID: 23040067]
  66. J Allergy Clin Immunol. 2018 Apr;141(4):1202-1207 [PMID: 29074454]
  67. Biochem Biophys Res Commun. 1997 Jul 30;236(3):712-5 [PMID: 9245719]
  68. Stroke. 1994 Dec;25(12):2331-6 [PMID: 7974569]
  69. Cell Mol Life Sci. 2014 Jan;71(2):271-85 [PMID: 23892892]
  70. J Clin Invest. 1998 Mar 15;101(6):1219-24 [PMID: 9502762]
  71. Eur Heart J. 2010 Mar;31(6):659-66 [PMID: 20159880]
  72. PLoS One. 2013 Dec 05;8(12):e80738 [PMID: 24339880]
  73. Clin Sci (Lond). 2013 Mar 13;125(1):19-25 [PMID: 23485061]
  74. Free Radic Biol Med. 2013 Dec;65:528-540 [PMID: 23891678]
  75. Clin Epigenetics. 2019 Aug 29;11(1):128 [PMID: 31464656]
  76. Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2017 Dec 1;38(3):121-133 [PMID: 29668472]
  77. Nucleic Acids Res. 2005 Dec 02;33(21):6823-36 [PMID: 16326863]
  78. Mol Biosyst. 2014 Nov;10(11):2775-82 [PMID: 25177824]
  79. Int J Cardiol. 2013 Oct 3;168(3):1837-40 [PMID: 23347612]
  80. Kidney Int. 2018 Jun;93(6):1330-1343 [PMID: 29477240]
  81. Endocrinology. 2005 Oct;146(10):4192-9 [PMID: 16002529]
  82. J Mol Cell Cardiol. 2012 Nov;53(5):668-76 [PMID: 22921780]
  83. Structure. 2011 Jan 12;19(1):7-15 [PMID: 21220111]
  84. Nat Commun. 2014 Apr 29;5:3746 [PMID: 24781383]
  85. J Biol Chem. 1990 Jul 15;265(20):11409-12 [PMID: 2164001]
  86. J Nutr. 1968 Feb;94(2):111-6 [PMID: 4230019]
  87. J Am Soc Nephrol. 2003 Aug;14(8 Suppl 3):S233-6 [PMID: 12874437]
  88. Science. 2010 Jan 8;327(5962):167-70 [PMID: 20056882]
  89. Hum Mol Genet. 2015 Jun 1;24(11):3021-9 [PMID: 25634562]
  90. Diabetes. 1997 Sep;46(9):1497-503 [PMID: 9287052]
  91. Int J Exp Pathol. 2009 Dec;90(6):638-48 [PMID: 19958400]
  92. Eur J Pharm Sci. 2012 Apr 11;45(5):592-9 [PMID: 22234377]
  93. Diabetes. 2015 Sep;64(9):3285-93 [PMID: 25931475]
  94. BMJ. 1993 Jan 23;306(6872):240-2 [PMID: 8443522]
  95. Mol Med Rep. 2016 Jun;13(6):4791-9 [PMID: 27082829]
  96. J Am Coll Cardiol. 2005 Jan 18;45(2):246-51 [PMID: 15653023]
  97. Diabetes Metab Syndr. 2016 Apr-Jun;10(2 Suppl 1):S176-83 [PMID: 27025794]
  98. J Atheroscler Thromb. 2016 Oct 1;23(10):1212-1221 [PMID: 27001002]
  99. Circ Res. 2014 May 9;114(10):1569-75 [PMID: 24663402]
  100. J Biol Chem. 1998 Apr 3;273(14):8225-31 [PMID: 9525928]
  101. Pediatr Res. 2016 Oct;80(4):602-9 [PMID: 27384406]
  102. Curr Top Med Chem. 2017;17(15):1750-1757 [PMID: 27848894]
  103. Sci Rep. 2018 Aug 24;8(1):12816 [PMID: 30143687]
  104. Proc Natl Acad Sci U S A. 2016 May 24;113(21):E3002-11 [PMID: 27162351]
  105. J Clin Invest. 2001 Nov;108(9):1341-8 [PMID: 11696579]
  106. PLoS One. 2013;8(1):e54662 [PMID: 23358711]
  107. N Engl J Med. 2003 Jun 5;348(23):2294-303 [PMID: 12788993]
  108. Nat Commun. 2016 Sep 30;7:12864 [PMID: 27686049]
  109. Am J Hypertens. 1988 Oct;1(4 Pt 1):335-47 [PMID: 3063284]
  110. J Clin Endocrinol Metab. 2009 Aug;94(8):2751-6 [PMID: 19491221]
  111. Arq Bras Cardiol. 2014 May;102(5):481-8 [PMID: 24918913]
  112. Hypertension. 2012 Mar;59(3):621-6 [PMID: 22311897]
  113. Epigenetics. 2017;12(11):991-1003 [PMID: 28886276]
  114. Nutr Metab Cardiovasc Dis. 2014 Jun;24(6):614-22 [PMID: 24477006]
  115. Contrib Nephrol. 1996;118:180-7 [PMID: 8744056]
  116. Diabetes. 1997 Apr;46(4):671-81 [PMID: 9075810]
  117. Proc Natl Acad Sci U S A. 1990 Jan;87(1):404-8 [PMID: 2296596]
  118. J Biol Chem. 2011 Jul 22;286(29):25586-603 [PMID: 21613227]
  119. BJOG. 2008 Sep;115(10):1243-9 [PMID: 18715409]
  120. Epigenetics. 2012 May;7(5):464-72 [PMID: 22419126]
  121. Exp Clin Endocrinol Diabetes. 2015 May;123(5):282-8 [PMID: 25962407]
  122. Endocrinology. 2012 Jun;153(6):2823-30 [PMID: 22434078]
  123. Kidney Int. 2014 Feb;85(2):362-73 [PMID: 24088954]
  124. JAMA. 2008 Dec 24;300(24):2886-97 [PMID: 19109117]
  125. Exp Cell Res. 2017 Jan 15;350(2):327-335 [PMID: 27964927]
  126. Kidney Int. 2011 Feb;79(3):317-30 [PMID: 20944551]
  127. N Engl J Med. 2008 Oct 9;359(15):1565-76 [PMID: 18784091]
  128. Reprod Sci. 2008 Sep;15(7):702-9 [PMID: 18562700]
  129. Diabetologia. 2018 Feb;61(2):354-368 [PMID: 29164275]
  130. Am J Physiol Endocrinol Metab. 2000 Jul;279(1):E83-7 [PMID: 10893326]
  131. Mol Metab. 2017 Jun 20;6(8):897-908 [PMID: 28752053]
  132. Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12222-6 [PMID: 11050244]
  133. J Am Soc Nephrol. 2016 Jul;27(7):2092-108 [PMID: 26701983]
  134. Vision Res. 2017 Oct;139:7-14 [PMID: 28412095]
  135. J Am Soc Nephrol. 2012 Mar;23(3):458-69 [PMID: 22223877]
  136. Diabetologia. 2004 Mar;47(3):541-548 [PMID: 14968292]
  137. J Biol Chem. 2010 Oct 29;285(44):34004-15 [PMID: 20713358]
  138. Adv Exp Med Biol. 2017;960:1-17 [PMID: 28585193]
  139. Nat Rev Genet. 2016 Sep 15;17(10):630-41 [PMID: 27629931]
  140. J Am Soc Nephrol. 2011 Aug;22(8):1462-74 [PMID: 21784902]
  141. Genome Res. 2012 Apr;22(4):623-32 [PMID: 22300631]
  142. Contrib Nephrol. 2011;170:36-47 [PMID: 21659756]
  143. Diabetes. 1987 Jul;36(7):808-12 [PMID: 3556280]
  144. Health Promot Chronic Dis Prev Can. 2019 Jun;39(6-7):216-224 [PMID: 31210047]
  145. Am J Physiol Renal Physiol. 2010 Jan;298(1):F133-41 [PMID: 19906951]
  146. JAMA. 2002 May 15;287(19):2563-9 [PMID: 12020338]
  147. Epigenetics. 2015;10(1):62-72 [PMID: 25496441]
  148. J Vasc Surg. 2017 Nov;66(5):1576-1586 [PMID: 28893489]
  149. Diabetes. 2018 Apr;67(4):731-744 [PMID: 29222368]
  150. Am J Pathol. 2011 May;178(5):2205-14 [PMID: 21514434]
  151. BMJ. 1990 Nov 17;301(6761):1111 [PMID: 2252919]
  152. Pediatr Res. 2013 Sep;74(3):344-9 [PMID: 23884163]
  153. J Pediatr Endocrinol Metab. 2015 Mar;28(3-4):251-63 [PMID: 25581748]
  154. BMJ. 1995 Feb 4;310(6975):296-7 [PMID: 7866171]
  155. N Engl J Med. 2005 Apr 21;352(16):1685-95 [PMID: 15843671]
  156. PLoS One. 2016 Apr 21;11(4):e0153920 [PMID: 27101308]
  157. J Biol Chem. 1992 Oct 15;267(29):20965-70 [PMID: 1400412]
  158. N Engl J Med. 2009 Jan 8;360(2):129-39 [PMID: 19092145]
  159. Int J Cardiol. 2013 Jul 31;167(2):531-6 [PMID: 22330002]
  160. Sci Transl Med. 2012 Feb 15;4(121):121ra18 [PMID: 22344686]
  161. Metabolism. 2015 Apr;64(4):489-97 [PMID: 25726255]
  162. Diabetes. 1995 Dec;44(12):1405-7 [PMID: 7589846]
  163. FASEB J. 2018 May 18;:fj201800237R [PMID: 29775417]
  164. Epigenetics. 2013 Dec;8(12):1289-302 [PMID: 24113149]
  165. PLoS One. 2012;7(7):e41462 [PMID: 22859986]
  166. Int J Clin Exp Med. 2014 Jan 15;7(1):136-41 [PMID: 24482699]
  167. PLoS One. 2012;7(10):e47193 [PMID: 23091611]
  168. Int J Obes (Lond). 2016 Apr;40(4):564-72 [PMID: 26607040]
  169. Diabetes. 2002 Aug;51(8):2612-8 [PMID: 12145178]
  170. Diabetes. 2016 Jan;65(1):216-27 [PMID: 26395742]
  171. Antioxid Redox Signal. 2018 Aug 1;29(4):355-376 [PMID: 29334763]
  172. Genes Dev. 2009 Jul 1;23(13):1494-504 [PMID: 19571179]
  173. Eur Heart J. 2017 Feb 14;38(7):516-523 [PMID: 27357355]
  174. FASEB J. 2008 Dec;22(12):4126-35 [PMID: 18716028]
  175. Am J Physiol Renal Physiol. 2013 Mar 1;304(5):F601-13 [PMID: 23235480]
  176. Epigenetics. 2014 Mar;9(3):366-76 [PMID: 24253112]
  177. Diabetes Care. 2018 May;41(5):917-928 [PMID: 29567642]
  178. J Am Soc Nephrol. 2012 Feb;23(2):252-65 [PMID: 22095944]
  179. Epigenetics. 2013 Sep;8(9):935-43 [PMID: 23975224]
  180. Nat Rev Endocrinol. 2016 Oct;12(10):616-22 [PMID: 27388988]
  181. N Engl J Med. 2008 Oct 9;359(15):1577-89 [PMID: 18784090]
  182. Physiol Genomics. 2004 Jun 17;18(1):43-50 [PMID: 15084713]
  183. Immunol Rev. 2012 Sep;249(1):218-38 [PMID: 22889225]
  184. J Clin Invest. 2016 Nov 1;126(11):4205-4218 [PMID: 27760051]
  185. J Am Heart Assoc. 2019 May 7;8(9):e010012 [PMID: 31018749]
  186. Ann N Y Acad Sci. 2015 Sep;1353:72-88 [PMID: 25877817]
  187. Int J Biol Sci. 2012;8(6):811-8 [PMID: 22719221]
  188. Clin Kidney J. 2019 Sep 18;12(6):861-870 [PMID: 31807301]
  189. Diabet Med. 2010 Aug;27(8):911-7 [PMID: 20653749]
  190. J Cardiovasc Pharmacol. 1997 Oct;30(4):528-32 [PMID: 9335415]
  191. N Engl J Med. 2011 Dec 22;365(25):2366-76 [PMID: 22077236]
  192. Science. 2003 May 2;300(5620):763 [PMID: 12730593]
  193. Diabetes. 2009 Nov;58(11):2642-8 [PMID: 19651816]
  194. Cardiovasc Drugs Ther. 2014 Aug;28(4):303-11 [PMID: 24924687]
  195. Mol Ther. 2014 Apr;22(4):842-53 [PMID: 24445937]
  196. Diabetologia. 2013 Mar;56(3):663-74 [PMID: 23292313]
  197. Diabetes Care. 2010 Nov;33(11):2436-41 [PMID: 20724651]
  198. Circulation. 2000 Feb 15;101(6):676-81 [PMID: 10673261]
  199. Nutrients. 2019 Jun 22;11(6): [PMID: 31234503]
  200. Atherosclerosis. 2013 Jun;228(2):346-52 [PMID: 23566804]
  201. Diabetes. 2008 Sep;57(9):2461-9 [PMID: 18511846]
  202. Biochim Biophys Acta. 2000 Jan 31;1490(1-2):163-9 [PMID: 10786632]
Journal Article Review
Article has an altmetric score of 4

Word Cloud

Created with Highcharts 10.0.0metabolicdiseasetreatmentnewexistingfailprimermemorykidneyDespitemassivegovernmentprivatesectorinvestmentspreventioncardiovasculardiabetesmellitusobesityeffortslargelyfailedburdencostremainsdownstreammorbiditymortalityoverallstagnatingoutcomesparadigmshiftapproachpatientsmayexplainstrategiesoffertargetsreviewaimsprovideclinician-centreddefinedsumirreversiblegeneticepigeneticcellulartissue-levelalterationsoccurlong-timeexposurederangementsmemory:diabesitytreatmentschronicdiabeticepigeneticssirtuin1

Similar Articles

Cited By