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Antioxidants (Basel, Switzerland)
Sep 18, 2021;10 (9):

NRF2 in Viral Infection.

Angela Herengt, Jacob Thyrsted, Christian K Holm
Author Information
  1. Angela Herengt: Aarhus Research Center for Innate Immunology, Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
  2. Jacob Thyrsted: Aarhus Research Center for Innate Immunology, Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
  3. Christian K Holm: Aarhus Research Center for Innate Immunology, Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
PMID: 34573123 DOI: 10.3390/antiox10091491

Abstract

The transcription factor NRF2 is central to redox homeostasis in animal cells and is a well-known driver of chemoresistance in many types of cancer. Recently, new roles have been ascribed to NRF2 which include regulation of antiviral interferon responses and inflammation. In addition, NRF2 is emerging as an important factor in antiviral immunity through interferon-independent mechanisms. In the review, we give an overview of the scientific progress on the involvement and importance of NRF2 in the context of viral infection.

Keywords

NRF2 immunology virus

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