OpenLB
Open Library of Bioscience
Advanced Search
Nutrients
Sep 04, 2021;13 (9):

Cord Serum Calcitriol Inversely Correlates with Maternal Blood Pressure in Urinary Tract Infection-Affected Pregnancies: Sex-Dependent Immune Implications.

Andrea Olmos-Ortiz, Alberto Olivares-Huerta, Janice Garc��a-Quiroz, Euclides Avila, Ali Halhali, Braulio Quesada-Reyna, Fernando Larrea, Ver��nica Zaga-Clavellina, Lorenza D��az
Author Information
  1. Andrea Olmos-Ortiz: Departamento de Biolog��a de la Reproducci��n "Dr. Carlos Gual Castro", Instituto Nacional de Ciencias M��dicas y Nutrici��n Salvador Zubir��n, Av. Vasco de Quiroga No. 15, Belisario Dom��nguez Secci��n XVI, Tlalpan, Ciudad de Mexico 14080, Mexico. ORCID
  2. Alberto Olivares-Huerta: Departamento de Biolog��a de la Reproducci��n "Dr. Carlos Gual Castro", Instituto Nacional de Ciencias M��dicas y Nutrici��n Salvador Zubir��n, Av. Vasco de Quiroga No. 15, Belisario Dom��nguez Secci��n XVI, Tlalpan, Ciudad de Mexico 14080, Mexico.
  3. Janice Garc��a-Quiroz: Departamento de Biolog��a de la Reproducci��n "Dr. Carlos Gual Castro", Instituto Nacional de Ciencias M��dicas y Nutrici��n Salvador Zubir��n, Av. Vasco de Quiroga No. 15, Belisario Dom��nguez Secci��n XVI, Tlalpan, Ciudad de Mexico 14080, Mexico. ORCID
  4. Euclides Avila: Departamento de Biolog��a de la Reproducci��n "Dr. Carlos Gual Castro", Instituto Nacional de Ciencias M��dicas y Nutrici��n Salvador Zubir��n, Av. Vasco de Quiroga No. 15, Belisario Dom��nguez Secci��n XVI, Tlalpan, Ciudad de Mexico 14080, Mexico. ORCID
  5. Ali Halhali: Departamento de Biolog��a de la Reproducci��n "Dr. Carlos Gual Castro", Instituto Nacional de Ciencias M��dicas y Nutrici��n Salvador Zubir��n, Av. Vasco de Quiroga No. 15, Belisario Dom��nguez Secci��n XVI, Tlalpan, Ciudad de Mexico 14080, Mexico.
  6. Braulio Quesada-Reyna: Divisi��n de Obstetricia, UMAE Hospital de Gineco-Obstetricia No. 4 "Luis Castelazo Ayala", IMSS, Rio de la Magdalena 289, Tizap��n San ��ngel, Progreso Tizap��n, ��lvaro Obreg��n, Ciudad de Mexico 01090, Mexico.
  7. Fernando Larrea: Departamento de Biolog��a de la Reproducci��n "Dr. Carlos Gual Castro", Instituto Nacional de Ciencias M��dicas y Nutrici��n Salvador Zubir��n, Av. Vasco de Quiroga No. 15, Belisario Dom��nguez Secci��n XVI, Tlalpan, Ciudad de Mexico 14080, Mexico.
  8. Ver��nica Zaga-Clavellina: Departamento de Fisiolog��a y Desarrollo Celular, Instituto Nacional de Perinatolog��a Isidro Espinosa de los Reyes, Montes Urales 800, Lomas-Virreyes, Lomas de Chapultepec IV Secci��n, Miguel Hidalgo, Ciudad de Mexico 11000, Mexico. ORCID
  9. Lorenza D��az: Departamento de Biolog��a de la Reproducci��n "Dr. Carlos Gual Castro", Instituto Nacional de Ciencias M��dicas y Nutrici��n Salvador Zubir��n, Av. Vasco de Quiroga No. 15, Belisario Dom��nguez Secci��n XVI, Tlalpan, Ciudad de Mexico 14080, Mexico. ORCID
PMID: 34578991 DOI: 10.3390/nu13093114

Abstract

Urinary tract infections (UTI) during pregnancy are frequently associated with hypertensive disorders, increasing the risk of perinatal morbidity. Calcitriol, vitamin D's most active metabolite, has been involved in blood pressure regulation and prevention of UTIs, partially through modulating vasoactive peptides and antimicrobial peptides, like cathelicidin. However, nothing is known regarding the interplay between placental calcitriol, cathelicidin, and maternal blood pressure in UTI-complicated pregnancies. Here, we analyzed the correlation between these parameters in pregnant women with UTI and with normal pregnancy (NP). Umbilical venous serum calcitriol and its precursor calcidiol were significantly elevated in UTI. Regardless of newborn's sex, we found strong negative correlations between calcitriol and maternal systolic and diastolic blood pressure in the UTI cohort ( < 0.002). In NP, this relationship was observed only in female-carrying mothers. UTI-female placentas showed higher expression of cathelicidin and CYP27B1, the calcitriol activating-enzyme, compared to male and NP samples. Accordingly, cord-serum calcitriol from UTI-female neonates negatively correlated with maternal bacteriuria. Cathelicidin gene expression positively correlated with gestational age in UTI and with newborn anthropometric parameters. Our results suggest that vitamin D deficiency might predispose to maternal cardiovascular risk and perinatal infections especially in male-carrying pregnancies, probably due to lower placental CYP27B1 and cathelicidin expression.

Keywords

blood pressure calcitriol pregnancy urinary tract infection vitamin D

References

  1. Am J Hypertens. 2002 Feb;15(2 Pt 1):170-5 [PMID: 11863253]
  2. Am J Obstet Gynecol. 2011 Jan;204(1):41.e1-9 [PMID: 20887971]
  3. Obstet Gynecol Surv. 1994 Dec;49(12 Suppl):S1-14 [PMID: 7877788]
  4. J Appl Physiol (1985). 2002 Feb;92(2):701-8 [PMID: 11796684]
  5. Jugosl Ginekol Perinatol. 1989 Jan-Apr;29(1-2):15-8 [PMID: 2739430]
  6. Am J Hypertens. 2001 Jun;14(6 Pt 2):178S-185S [PMID: 11411754]
  7. Obstet Gynecol Surv. 1994 Dec;49(12):830-9 [PMID: 7885660]
  8. Nutr Metab Cardiovasc Dis. 2013 Oct;23(10):960-6 [PMID: 24095147]
  9. BJOG. 2008 Mar;115(4):492-500 [PMID: 18271886]
  10. Heart. 2013 Dec;99(24):1849-56 [PMID: 24125739]
  11. Science. 1979 Jun 22;204(4399):1311-3 [PMID: 451538]
  12. Eur J Obstet Gynecol Reprod Biol. 2019 Dec;243:51-56 [PMID: 31671292]
  13. Placenta. 2008 Sep;29(9):763-71 [PMID: 18687466]
  14. Malays Fam Physician. 2007 Aug 31;2(2):54-7 [PMID: 25606081]
  15. Front Immunol. 2018 Mar 02;9:408 [PMID: 29599772]
  16. J Am Heart Assoc. 2019 May 7;8(9):e011485 [PMID: 31020895]
  17. J Clin Invest. 2002 Jul;110(2):229-38 [PMID: 12122115]
  18. Placenta. 2011 Dec;32(12):956-62 [PMID: 22018415]
  19. Annu Rev Pathol. 2010;5:173-92 [PMID: 20078220]
  20. J Clin Endocrinol Metab. 2001 Apr;86(4):1633-7 [PMID: 11297596]
  21. Medicine (Baltimore). 2018 Sep;97(36):e12192 [PMID: 30200124]
  22. Int J Mol Sci. 2019 Jul 26;20(15): [PMID: 31357391]
  23. Eur J Pediatr. 2018 Oct;177(10):1541-1545 [PMID: 30027298]
  24. Am J Obstet Gynecol. 1986 Dec;155(6):1223-6 [PMID: 3538876]
  25. J Bone Miner Res. 2019 Jun;34(6):1068-1073 [PMID: 30790351]
  26. J Steroid Biochem Mol Biol. 2016 Oct;163:173-82 [PMID: 27210415]
  27. J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30 [PMID: 21646368]
  28. J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):387-92 [PMID: 15225806]
  29. PLoS One. 2010 Dec 14;5(12):e15580 [PMID: 21179490]
  30. Am J Physiol Heart Circ Physiol. 2016 Dec 1;311(6):H1459-H1469 [PMID: 27769995]
  31. Pregnancy Hypertens. 2021 Jun;24:65-72 [PMID: 33677421]
  32. Am J Hypertens. 1989 Jan;2(1):20-5 [PMID: 2643969]
  33. J Reprod Immunol. 2017 Jun;121:42-48 [PMID: 28622535]
  34. BMC Infect Dis. 2018 Jan 8;18(1):17 [PMID: 29310594]
  35. Am J Obstet Gynecol. 2021 Jun;224(6):623-624 [PMID: 33675794]
  36. Toxicol Appl Pharmacol. 2020 May 1;394:114950 [PMID: 32147540]
  37. Biol Reprod. 2016 May;94(5):116 [PMID: 27075619]
  38. J Immunol. 2004 Sep 1;173(5):2909-12 [PMID: 15322146]
  39. Am J Clin Nutr. 2017 Dec;106(6):1439-1448 [PMID: 29021285]
  40. J Steroid Biochem Mol Biol. 2015 Apr;148:187-93 [PMID: 25088189]
  41. J Reprod Immunol. 2009 Jul;81(1):17-24 [PMID: 19501915]
  42. Nutrients. 2015 Jan 09;7(1):443-80 [PMID: 25584965]
  43. J Am Soc Nephrol. 2006 Dec;17(12):3267-3272 [PMID: 37001006]
  44. Am J Hypertens. 1995 Sep;8(9):894-901 [PMID: 8541004]
  45. J Perinat Med. 1987;15(3):282-90 [PMID: 3501463]
  46. Acta Paediatr. 2019 Mar;108(3):551-556 [PMID: 30003595]
  47. J Clin Endocrinol Metab. 2007 Sep;92(9):3517-22 [PMID: 17535985]
  48. Science. 1996 Nov 8;274(5289):995-8 [PMID: 8875944]
  49. Am J Perinatol. 2020 Dec;37(14):1446-1454 [PMID: 31365935]
  50. Glob J Health Sci. 2016 Jan 04;8(9):54008 [PMID: 27157170]
  51. J Steroid Biochem Mol Biol. 2014 Oct;144 Pt A:106-9 [PMID: 24361583]
  52. Ann Nutr Metab. 2017;70(2):79-87 [PMID: 28315864]
  53. Biol Reprod. 2009 Mar;80(3):398-406 [PMID: 19005165]
  54. Am J Reprod Immunol. 2018 Jun;79(6):e12841 [PMID: 29493045]
  55. Medicine (Baltimore). 2016 Jul;95(27):e4137 [PMID: 27399128]
  56. Infect Dis (Lond). 2016 Nov-Dec;48(11-12):823-8 [PMID: 27357103]
  57. Front Immunol. 2017 Mar 13;8:273 [PMID: 28348564]
  58. Gland Surg. 2020 Feb;9(1):142-149 [PMID: 32206606]
  59. Circulation. 2014 Sep 16;130(12):1003-8 [PMID: 25223771]
  60. Arch Public Health. 2020 Jun 04;78:31 [PMID: 32518650]
  61. Clin Nutr. 2019 Apr;38(2):557-563 [PMID: 29550150]
  62. Clin Sci (Lond). 1999 Apr;96(4):427-30 [PMID: 10087252]
  63. Science. 2006 Mar 24;311(5768):1770-3 [PMID: 16497887]
  64. Hypertension. 2014 Dec;64(6):1290-8 [PMID: 25201890]
  65. Clin Microbiol Infect. 2015 May;21(5):482.e1-7 [PMID: 25640157]

Grants

  1. CB2014-24162/Consejo Nacional de Ciencia y Tecnolog��a
  2. 3210-21205-01-14/Instituto Nacional de Perinatolog��a Isidro Espinosa de los Reyes

MeSH Term

25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Adult
Antimicrobial Cationic Peptides
Blood Pressure
Calcitriol
Female
Fetal Blood
Gestational Age
Humans
Infant, Newborn
Male
Placenta
Pregnancy
Pregnancy Complications, Infectious
Sex Factors
Urinary Tract Infections
Vitamin D Deficiency
Cathelicidins

Chemicals

Antimicrobial Cationic Peptides
25-Hydroxyvitamin D3 1-alpha-Hydroxylase
CYP27B1 protein, human
Calcitriol
Cathelicidins
Journal Article

Word Cloud

Created with Highcharts 10.0.0calcitriolUTIbloodpressurecathelicidinmaternalpregnancyvitaminNPexpressionUrinarytractinfectionsriskperinatalCalcitriolpeptidesplacentalpregnanciesparametersUTI-femaleCYP27B1correlatedDfrequentlyassociatedhypertensivedisordersincreasingmorbidityD'sactivemetaboliteinvolvedregulationpreventionUTIspartiallymodulatingvasoactiveantimicrobiallikeHowevernothingknownregardinginterplayUTI-complicatedanalyzedcorrelationpregnantwomennormalUmbilicalvenousserumprecursorcalcidiolsignificantlyelevatedRegardlessnewborn'ssexfoundstrongnegativecorrelationssystolicdiastoliccohort<0002relationshipobservedfemale-carryingmothersplacentasshowedhigheractivating-enzymecomparedmalesamplesAccordinglycord-serumneonatesnegativelybacteriuriaCathelicidingenepositivelygestationalagenewbornanthropometricresultssuggestdeficiencymightpredisposecardiovascularespeciallymale-carryingprobablyduelowerCordSerumInverselyCorrelatesMaternalBloodPressureTractInfection-AffectedPregnancies:Sex-DependentImmuneImplicationsurinaryinfection

Similar Articles

Cited By