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European journal of applied physiology
Jan, 2022;122 (1): 141-155.

Ischemic preconditioning of the muscle reduces the metaboreflex response of the knee extensors.

Luca Angius, Benjamin Pageaux, Antonio Crisafulli, James Hopker, Samuele Maria Marcora
Author Information
  1. Luca Angius: Faculty of Health and Life Sciences, Department of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne, UK. luca.angius@northumbria.ac.uk. ORCID
  2. Benjamin Pageaux: École de Kinésiologie et des Sciences de l'Activité Physique (EKSAP), Faculté de Médicine, Université de Montréal, Montréal, QC, Canada. ORCID
  3. Antonio Crisafulli: The Department of Medical Sciences, Sports Physiology Laboratory, University of Cagliari, Cagliari, Italy. ORCID
  4. James Hopker: Endurance Research Group, School of Sport and Exercise Sciences, University of Kent, Chatham Maritime, UK. ORCID
  5. Samuele Maria Marcora: Endurance Research Group, School of Sport and Exercise Sciences, University of Kent, Chatham Maritime, UK. ORCID
PMID: 34596759 DOI: 10.1007/s00421-021-04815-0

Abstract

PURPOSE: This study investigated the effect of ischemic preconditioning (IP) on metaboreflex activation following dynamic leg extension exercise in a group of healthy participants.
METHOD: Seventeen healthy participants were recruited. IP and SHAM treatments (3 × 5 min cuff occlusion at 220 mmHg or 20 mmHg, respectively) were administered in a randomized order to the upper part of exercising leg's thigh only. Muscle pain intensity (MP) and pain pressure threshold (PPT) were monitored while administrating IP and SHAM treatments. After 3 min of leg extension exercise at 70% of the maximal workload, a post-exercise muscle ischemia (PEMI) was performed to monitor the discharge group III/IV muscle afferents via metaboreflex activation. Hemodynamics were continuously recorded. MP was monitored during exercise and PEMI.
RESULTS: IP significantly reduced mean arterial pressure compared to SHAM during metaboreflex activation (mean ± SD, 109.52 ± 7.25 vs. 102.36 ± 7.89 mmHg) which was probably the consequence of a reduced end diastolic volume (mean ± SD, 113.09 ± 14.25 vs. 102.42 ± 9.38 ml). MP was significantly higher during the IP compared to SHAM treatment, while no significant differences in PPT were found. MP did not change during exercise, but it was significantly lower during the PEMI following IP (5.10 ± 1.29 vs. 4.00 ± 1.54).
CONCLUSION: Our study demonstrated that IP reduces hemodynamic response during metaboreflex activation, while no effect on MP and PPT were found. The reduction in hemodynamic response was likely the consequence of a blunted venous return.

Keywords

Afferent feedback Exercise Ischemic preconditioning Metaboreflex Pain Performance

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MeSH Term

Adult
Energy Metabolism
Female
Healthy Volunteers
Hemodynamics
Humans
Ischemic Preconditioning
Knee Joint
Male
Muscle, Skeletal
Myalgia
Pain Measurement
Reflex
Journal Article
Article has an altmetric score of 6

Word Cloud

Created with Highcharts 10.0.0IPmetaboreflexMPactivationexerciseSHAMpreconditioningPPTmusclePEMIsignificantlyvsresponsestudyeffectfollowinglegextensiongrouphealthyparticipantstreatmentspainpressuremonitoredreducedcomparedmean ± SD25102consequencefoundreduceshemodynamicIschemicPURPOSE:investigatedischemicdynamicMETHOD:Seventeenrecruited3 × 5 mincuffocclusion220 mmHg20 mmHgrespectivelyadministeredrandomizedorderupperpartexercisingleg'sthighMuscleintensitythresholdadministrating3 min70%maximalworkloadpost-exerciseischemiaperformedmonitordischargeIII/IVafferentsviaHemodynamicscontinuouslyrecordedRESULTS:meanarterial10952 ± 736 ± 789 mmHgprobablyenddiastolicvolume11309 ± 1442 ± 938 mlhighertreatmentsignificantdifferenceschangelower510 ± 129400 ± 154CONCLUSION:demonstratedreductionlikelybluntedvenousreturnkneeextensorsAfferentfeedbackExerciseMetaboreflexPainPerformance

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