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2021;6 219.

Genotype data not consistent with clonal transmission of sea turtle fibropapillomatosis or goldfish schwannoma.

Máire Ní Leathlobhair, Kelsey Yetsko, Jessica A Farrell, Carmelo Iaria, Gabriele Marino, David J Duffy, Elizabeth P Murchison
Author Information
  1. Máire Ní Leathlobhair: Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, UK. ORCID
  2. Kelsey Yetsko: The Whitney Laboratory for Marine Bioscience, Sea Turtle Hospital, University of Florida, St. Augustine, Florida, 32080, USA.
  3. Jessica A Farrell: The Whitney Laboratory for Marine Bioscience, Sea Turtle Hospital, University of Florida, St. Augustine, Florida, 32080, USA.
  4. Carmelo Iaria: Centre of Experimental Fish Pathology of Sicily (CISS), Viale Giovanni Palatucci, University of Messina, 98168, Messina, Italy. ORCID
  5. Gabriele Marino: Department of Veterinary Sciences, Viale Giovanni Palatucci, University of Messina, 98168, Messina, Italy.
  6. David J Duffy: The Whitney Laboratory for Marine Bioscience, Sea Turtle Hospital, University of Florida, St. Augustine, Florida, 32080, USA. ORCID
  7. Elizabeth P Murchison: Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK. ORCID
PMID: 34622016 DOI: 10.12688/wellcomeopenres.17073.1

Abstract

Recent discoveries of transmissible cancers in multiple bivalve species suggest that direct transmission of cancer cells within species may be more common than previously thought, particularly in aquatic environments. Fibropapillomatosis occurs with high prevalence in green sea turtles ( ) and the geographic range of disease has increased since fibropapillomatosis was first reported in this species. Widespread incidence of schwannomas, benign tumours of Schwann cell origin, reported in aquarium-bred goldfish suggest an infectious aetiology. We investigated the hypothesis that cancers in these species arise by clonal transmission of cancer cells. Through analysis of polymorphic microsatellite alleles, we demonstrate concordance of host and tumour genotypes in diseased animals. These results imply that the tumours examined arose from independent oncogenic transformation of host tissue and were not clonally transmitted. Further, failure to experimentally transmit goldfish schwannoma via water exposure or inoculation suggest that this disease is unlikely to have an infectious aetiology.

Keywords

fibropapillomatosis goldfish schwannoma sea turtle fibropapillomatosis transmissible cancer wildlife cancer

Associated Data

Dryad | 10.5061/dryad.1zcrjdfsg

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Grants

  1. /Wellcome Trust
  2. 102942/Z/13/A/Wellcome Trust
Journal Article
Article has an altmetric score of 2

Word Cloud

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