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Scandinavian journal of medicine & science in sports
02, 2022;32 (2): 359-371.

Effects of blood-flow restricted resistance training on mechanical muscle function and thigh lean mass in sIBM patients.

Anders N. Jørgensen, Kasper Y. Jensen, Jakob L. Nielsen, Ulrik Frandsen, Lars G. Hvid, Mette Bjørnshauge, Louise P. Diederichsen, Per Aagaard
Author Information
  1. Anders N. Jørgensen: Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. ORCID
  2. Kasper Y. Jensen: Center for Rheumatology and Spine Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. ORCID
  3. Jakob L. Nielsen: Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. ORCID
  4. Ulrik Frandsen: Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
  5. Lars G. Hvid: Exercise Biology, Department of Public Health, Aarhus University, Aarhus, Denmark. ORCID
  6. Mette Bjørnshauge: Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
  7. Louise P. Diederichsen: Center for Rheumatology and Spine Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. ORCID
  8. Per Aagaard: Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. ORCID
PMID: 34637559 DOI: 10.1111/sms.14079

Abstract

Sporadic inclusion body myositis (sIBM) is an idiopathic inflammatory muscle disease associated with skeletal muscle inflammation and a parallel progressive decline in muscle strength and physical function. Eventually, most sIBM patients require use of wheelchair after about 10 years of diagnosis and assistance to perform activities of daily living. This study presents data from a randomized controlled intervention trial (NCT02317094) that examined the effect of 12 weeks low-load blood-flow restricted (BFR) resistance training on maximal muscle strength, power, rate of force development (RFD), thigh lean mass (TLM), and voluntary muscle activation (VA) in sIBM patients. A time-by-group interaction in knee extensor strength was observed in the stronger leg (p ≤ 0.033) but not the weaker leg. Within-group changes were observed with BFR training (BFR) manifested by increased knee extensor strength in the strongest leg (+13.7%, p = 0.049), whereas non-exercising patients (CON) showed reduced knee extensor strength (-7.7%, p = 0.018). Maximal leg extensor power obtained for the stronger leg remained unchanged following BFR training (+9.5%, p = 0.37) while decreasing in CON (-11.1%, p = 0.05). No changes in TLM were observed. VA declined post-training (p = 0.037) in both BFR (-6.3% points) and CON (-7.5% points). The present data indicate that BFR resistance training can attenuate the rate of decline in mechanical muscle function typically experienced by sIBM patients. The preservation of muscle mass and mechanical muscle function with BFR resistance training may be considered of high clinical importance in sIBM patients to countermeasure the disease-related decline in physical function.

Keywords

limb asymmetry rate of force development rehabilitation sporadic inclusion body myositis voluntary muscle activation

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Grants

  1. /The A.P. Moller Foundation
  2. /The Danish Rheumatism Association
  3. /The Region of Southern Denmark

MeSH Term

Activities of Daily Living
Humans
Muscle Strength
Muscle, Skeletal
Myositis, Inclusion Body
Regional Blood Flow
Resistance Training
Thigh
Journal Article Randomized Controlled Trial

Word Cloud

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