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Sep 30, 2021;11 (10):

Basic Quality Controls Used in Skin Tissue Engineering.

Laura Linares-Gonzalez, Teresa Rodenas-Herranz, Fernando Campos, Ricardo Ruiz-Villaverde, Víctor Carriel
Author Information
  1. Laura Linares-Gonzalez: Servicio de Dermatología, Hospital Universitario San Cecilio, 18016 Granada, Spain.
  2. Teresa Rodenas-Herranz: Servicio de Dermatología, Hospital Universitario San Cecilio, 18016 Granada, Spain.
  3. Fernando Campos: Ibs. GRANADA, Instituto Biosanitario de Granada, 18016 Granada, Spain. ORCID
  4. Ricardo Ruiz-Villaverde: Servicio de Dermatología, Hospital Universitario San Cecilio, 18016 Granada, Spain. ORCID
  5. Víctor Carriel: Ibs. GRANADA, Instituto Biosanitario de Granada, 18016 Granada, Spain. ORCID
PMID: 34685402 DOI: 10.3390/life11101033

Abstract

Reconstruction of skin defects is often a challenging effort due to the currently limited reconstructive options. In this sense, tissue engineering has emerged as a possible alternative to replace or repair diseased or damaged tissues from the patient's own cells. A substantial number of tissue-engineered skin substitutes (TESSs) have been conceived and evaluated in vitro and in vivo showing promising results in the preclinical stage. However, only a few constructs have been used in the clinic. The lack of standardization in evaluation methods employed may in part be responsible for this discrepancy. This review covers the most well-known and up-to-date methods for evaluating the optimization of new TESSs and orientative guidelines for the evaluation of TESSs are proposed.

Keywords

biochemical methods biomechanical evaluation histological techniques quality control skin tissue engineering

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