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Journal of oncology
2021;2021 1049104.

Upregulation of GTPBP4 Promotes the Proliferation of Liver Cancer Cells.

Jia Chen, Jie Zhang, Zhiwei Zhang
Author Information
  1. Jia Chen: Cancer Research Institute of Hengyang Medical College, University of South China, Hengyang, China.
  2. Jie Zhang: Department of Laboratory Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
  3. Zhiwei Zhang: Cancer Research Institute of Hengyang Medical College, University of South China, Hengyang, China. ORCID
PMID: 34712323 DOI: 10.1155/2021/1049104

Abstract

RESULTS: The GTPBP4 has upregulated expression in liver cancer patients ( < 0.01), but there was no difference in its expression in patients with different clinicopathological stages. The expression of GTPBP4 increased with the increase of cancer metastasis in lymph nodes ( < 0.01). Liver cancer patients with upregulated expression of GTPBP4 showed a shorter overall survival rate (=0.02). GTPBP4 is closely related to genes such as NIFK, WDR12, and RPF2, and these genes are involved in life processes such as GTP binding and rRNA processing. The upregulated expression of GTPBP4 promotes the proliferation of liver cancer cells and promotes the growth of tumors in mice, while the downregulated expression of GTPBP4 inhibits the proliferation of liver cancer cells and inhibits the growth of tumors in mice.
CONCLUSION: The expression of GTPBP4 is upregulated in liver cancer patients and affects the overall survival rate of patients. The upregulated expression of GTPBP4 promotes the proliferation of liver cancer cells and the growth of tumors.

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