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PLoS neglected tropical diseases
11, 2021;15 (11): e0009842.

Emerging hantaviruses in Central Argentina: First case of Hantavirus Pulmonary Syndrome caused by Alto Paraguay virus, and a novel orthohantavirus in Scapteromys aquaticus rodent.

Carla Bellomo, Daniel Oscar Alonso, Tamara Ricardo, Rocío Coelho, Sebastián Kehl, Natalia Periolo, Viviana Azogaray, Natalia Casas, Mariano Ottonelli, Laura Cristina Bergero, María Carolina Cudós, María Andrea Previtali, Valeria Paula Martinez
Author Information
  1. Carla Bellomo: Instituto Nacional de Enfermedades Infecciosas-Administración Nacional de Laboratorios e Institutos de Salud "Dr. C. Malbrán", Buenos Aires, Argentina. ORCID
  2. Daniel Oscar Alonso: Instituto Nacional de Enfermedades Infecciosas-Administración Nacional de Laboratorios e Institutos de Salud "Dr. C. Malbrán", Buenos Aires, Argentina. ORCID
  3. Tamara Ricardo: Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Santa Fé, Argentina. ORCID
  4. Rocío Coelho: Instituto Nacional de Enfermedades Infecciosas-Administración Nacional de Laboratorios e Institutos de Salud "Dr. C. Malbrán", Buenos Aires, Argentina. ORCID
  5. Sebastián Kehl: Instituto Nacional de Enfermedades Infecciosas-Administración Nacional de Laboratorios e Institutos de Salud "Dr. C. Malbrán", Buenos Aires, Argentina.
  6. Natalia Periolo: Instituto Nacional de Enfermedades Infecciosas-Administración Nacional de Laboratorios e Institutos de Salud "Dr. C. Malbrán", Buenos Aires, Argentina. ORCID
  7. Viviana Azogaray: Laboratorio Central de la Provincia de Santa Fe, Santa Fé, Argentina.
  8. Natalia Casas: Ministerio de Salud de la Nación, Programa Nacional de Control de Enfermedades Zoonóticas, Buenos Aires, Argentina.
  9. Mariano Ottonelli: Dirección de Epidemiología, Ministerio de Salud de Santa Fe, Santa Fé, Argentina. ORCID
  10. Laura Cristina Bergero: Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Santa Fé, Argentina. ORCID
  11. María Carolina Cudós: Dirección de Epidemiología, Ministerio de Salud de Santa Fe, Santa Fé, Argentina. ORCID
  12. María Andrea Previtali: Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Santa Fé, Argentina.
  13. Valeria Paula Martinez: Instituto Nacional de Enfermedades Infecciosas-Administración Nacional de Laboratorios e Institutos de Salud "Dr. C. Malbrán", Buenos Aires, Argentina. ORCID
PMID: 34788281 DOI: 10.1371/journal.pntd.0009842

Abstract

Orthohantaviruses are emerging rodent-borne pathogens that cause Hantavirus Pulmonary Syndrome in humans. They have a wide range of rodent reservoir hosts and are transmitted to humans through aerosolized viral particles generated by the excretions of infected individuals. Since the first description of HPS in Argentina, new hantaviruses have been reported throughout the country, most of which are pathogenic to humans. We present here the first HPS case infected with Alto Paraguay virus reported in Argentina. Until now, Alto Paraguay virus was considered a non-pathogenic orthohantavirus since it was identified in a rodent, Holochilus chacarius. In addition to this, with the goal of identifying potential hantavirus host species in the province of Santa Fe, we finally describe a novel orthohantavirus found in the native rodent Scapteromys aquaticus, which differed from other hantaviruses described in the country so far. Our findings implicate an epidemiological warning regarding these new orthohantaviruses circulating in Central Argentina as well as new rodent species that must be considered as hosts from now on.

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MeSH Term

Adolescent
Animals
Antibodies, Viral
Argentina
Disease Reservoirs
Female
Orthohantavirus
Hantavirus Pulmonary Syndrome
Humans
Male
Phylogeny
Sigmodontinae

Chemicals

Antibodies, Viral
Case Reports Journal Article
Article has an altmetric score of 9

Word Cloud

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