This study aims to assess the changes in cardiovascular Remodeling attributable to bodyweight gain in a middle-aged abdominal obesity cohort. A Remodeling worsening might explain the increase in cardiovascular risk associated with a dynamic of Weight Gain. Seventy-five middle-aged subjects (56 ± 5 years, 38 women) with abdominal obesity and no known cardiovascular disease underwent MRI-based examinations at baseline and at a 6.1 ± 1.2-year follow-up to monitor cardiovascular Remodeling and hemodynamic variables, most notably the effective arterial elastance (Ea). Ea is a proxy of the arterial load that must be overcome during left ventricular (LV) ejection, with increased EA resulting in concentric LV Remodeling. Sixteen obese subjects had significant Weight Gain (>7%) during follow-up (WG+), whereas the 59 other individuals did not (WG-). WG+ and WG- exhibited significant differences in the baseline to follow-up evolutions of several hemodynamic parameters, notably diastolic and mean blood pressures (for mean blood pressure, WG+: +9.3 ± 10.9 mmHg vs. WG-: +1.7 ± 11.8 mmHg, p = 0.022), heart rate (WG+: +0.6 ± 9.4 min vs. -8.9 ± 11.5 min, = 0.003), LV concentric Remodeling index (WG: +0.08 ± 0.16 g.mL vs. WG-: -0.02 ± 0.13 g.mL, = 0.018) and Ea (WG+: +0.20 ± 0.28 mL mmHg vs. WG-: +0.01 ± 0.30 mL mmHg, = 0.021). The evolution of the LV concentric Remodeling index and Ea were also strongly correlated in the overall obese population ( < 0.001, R = 0.31). A Weight Gain dynamic is accompanied by increases in arterial load and load-related concentric LV Remodeling in an isolated abdominal obesity cohort. This Remodeling could have a significant impact on cardiovascular risk.
