Advanced approaches for improving bioavailability and controlled release of anthocyanins.
Yixiao Shen, Ning Zhang, Jinlong Tian, Guang Xin, Ling Liu, Xiyun Sun, Bin Li
Author Information
Yixiao Shen: College of Food Science, Shenyang Agricultural University, Shenyang, Liaoning 110161, China.
Ning Zhang: College of Horticulture Science and Technology, Hebei Normal University of Science & Technology, Hebei Key Laboratory of Horticulture Germplasm Excavation and Innovative Utilization Qinhuangdao, Hebei, China.
Jinlong Tian: College of Food Science, Shenyang Agricultural University, Shenyang, Liaoning 110161, China.
Guang Xin: College of Food Science, Shenyang Agricultural University, Shenyang, Liaoning 110161, China.
Ling Liu: College of Food Science, Shenyang Agricultural University, Shenyang, Liaoning 110161, China.
Xiyun Sun: College of Food Science, Shenyang Agricultural University, Shenyang, Liaoning 110161, China.
Bin Li: College of Food Science, Shenyang Agricultural University, Shenyang, Liaoning 110161, China. Electronic address: libinsyau@163.com.
anthocyanins are a group of phytochemicals responsible for the purple or red color of plants. Additionally, they are recognized to have health promoting functions including anti-cardiovascular, anti-thrombotic, anti-diabetic, antimicrobial, neuroprotective, and visual protective effect as well as anti-cancer activities. Thus, consumption of anthocyanin supplement or anthocyanin-rich foods has been recommended to prevent the risk of development of chronic diseases. However, the low stability and bioavailability of anthocyanins limit the efficacy and distribution of anthocyanins in human body. Thus, strategies to achieve target site-local delivery with good bioavailability and controlled release rate are necessary. This review introduced and discussed the latest advanced techniques of designing lipid-based, polysaccharide-based and protein-based complexes, nano-encapsulation and exosome to overcome the limitation of anthocyanins. The improved bioavailability and controlled release of anthocyanins have great significance for gastrointestinal tract absorption, transepithelial transportation and cellular uptake. The techniques of applying different biocompatible materials and modifying the solubility of anthocyanins complex could achieve target site-local delivery with negligible degradation and good bioavailability in human body.
