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Antibiotics (Basel, Switzerland)
Nov 17, 2021;10 (11):

Mechanisms of Resistance to Macrolide Antibiotics among .

Maria Miklasińska-Majdanik
Author Information
  1. Maria Miklasińska-Majdanik: Department of Microbiology and Virology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jagiellońska 4, 41-200 Sosnowiec, Poland. ORCID
PMID: 34827344 DOI: 10.3390/antibiotics10111406

Abstract

Methicillin resistant strains pose a serious treatment problem because of their multi-drug resistance (MDR). In staphylococcal strains, resistance to macrolides, lincosamides, and streptogramin B (MLS) correlates with resistance to methicillin. The rapid transmission of genes responsible for MLS resistance has strongly limited the clinical application of traditional macrolides such as erythromycin. On the other hand, in the age of increasing insensitivity to antibiotics the idea of implementing a therapy based on older generation drugs brings hope that the spread of antibiotic resistance will be limited. A thorough understanding of the resistance mechanisms contributes to design of antibiotics that avoid bacterial insensitivity. This review highlights the mechanisms of action of macrolides and mechanism of resistance to these antibiotics among .

Keywords

Staphylococcus aureus macrolides resistance

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Grants

  1. PCN-1-058/N/0/I/Medical University of Silesia
Journal Article Review
Article has an altmetric score of 1

Word Cloud

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