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Oct 20, 2021;11 (11):

Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression.

Cornelia Tolg, Britney Jodi-Ann Messam, James Benjamin McCarthy, Andrew Cook Nelson, Eva Ann Turley
Author Information
  1. Cornelia Tolg: London Regional Cancer Program, Lawson Health Research Institute, London, ON N6A 5W9, Canada.
  2. Britney Jodi-Ann Messam: Department Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada. ORCID
  3. James Benjamin McCarthy: Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA. ORCID
  4. Andrew Cook Nelson: Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA. ORCID
  5. Eva Ann Turley: London Regional Cancer Program, Lawson Health Research Institute, Department Oncology, Biochemistry and Surgery, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada.
PMID: 34827550 DOI: 10.3390/biom11111551

Abstract

Signaling from an actively remodeling extracellular matrix (ECM) has emerged as a critical factor in regulating both the repair of tissue injuries and the progression of diseases such as metastatic cancer. Hyaluronan (HA) is a major component of the ECM that normally functions in tissue injury to sequentially promote then suppress inflammation and fibrosis, a duality in which is featured, and regulated in, wound repair. These essential response-to-injury functions of HA in the microenvironment are hijacked by tumor cells for invasion and avoidance of immune detection. In this review, we first discuss the numerous size-dependent functions of HA and emphasize the multifunctional nature of two of its receptors (CD44 and RHAMM) in regulating the signaling duality of HA in excisional wound healing. This is followed by a discussion of how HA metabolism is de-regulated in malignant progression and how targeting HA might be used to better manage breast cancer progression.

Keywords

CD44 RHAMM breast cancer hyaluronan wound repair

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MeSH Term

Hyaluronic Acid
Humans
Wound Healing
Breast Neoplasms
Hyaluronan Receptors
Disease Progression
Female
Animals
Extracellular Matrix
Tumor Microenvironment
Signal Transduction
Extracellular Matrix Proteins

Chemicals

Hyaluronic Acid
Hyaluronan Receptors
hyaluronan-mediated motility receptor
Extracellular Matrix Proteins
Journal Article Review

Word Cloud

Created with Highcharts 10.0.0HArepairprogressioncancerfunctionswoundECMregulatingtissueHyaluronandualityCD44RHAMMbreastSignalingactivelyremodelingextracellularmatrixemergedcriticalfactorinjuriesdiseasesmetastaticmajorcomponentnormallyinjurysequentiallypromotesuppressinflammationfibrosisfeaturedregulatedessentialresponse-to-injurymicroenvironmenthijackedtumorcellsinvasionavoidanceimmunedetectionreviewfirstdiscussnumeroussize-dependentemphasizemultifunctionalnaturetworeceptorssignalingexcisionalhealingfolloweddiscussionmetabolismde-regulatedmalignanttargetingmightusedbettermanageFunctionsWoundRepairCapturedFuelBreastCancerProgressionhyaluronan

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