Resistant Starch Consumption Effects on Glycemic Control and Glycemic Variability in Patients with Type 2 Diabetes: A Randomized Crossover Study.
Yolanda Arias-Córdova, Jorge Luis Ble-Castillo, Carlos García-Vázquez, Viridiana Olvera-Hernández, Meztli Ramos-García, Adrián Navarrete-Cortes, Guadalupe Jiménez-Domínguez, Isela Esther Juárez-Rojop, Carlos Alfonso Tovilla-Zárate, Mirian Carolina Martínez-López, José D Méndez
Author Information
Yolanda Arias-Córdova: Centro de Investigación, División Académica de Ciencias de la Salud (DACS), Universidad Juárez Autónoma de Tabasco (UJAT), Villahermosa 86150, Mexico.
Jorge Luis Ble-Castillo: Centro de Investigación, División Académica de Ciencias de la Salud (DACS), Universidad Juárez Autónoma de Tabasco (UJAT), Villahermosa 86150, Mexico. ORCID
Carlos García-Vázquez: Centro de Investigación, División Académica de Ciencias de la Salud (DACS), Universidad Juárez Autónoma de Tabasco (UJAT), Villahermosa 86150, Mexico. ORCID
Viridiana Olvera-Hernández: Centro de Investigación, División Académica de Ciencias de la Salud (DACS), Universidad Juárez Autónoma de Tabasco (UJAT), Villahermosa 86150, Mexico.
Meztli Ramos-García: Centro de Investigación, División Académica de Ciencias de la Salud (DACS), Universidad Juárez Autónoma de Tabasco (UJAT), Villahermosa 86150, Mexico. ORCID
Adrián Navarrete-Cortes: Departamento de Medicina Interna, Hospital General de Zona No. 46, Instituto Mexicano del Seguro Social (IMSS), Villahermosa 86060, Mexico.
Guadalupe Jiménez-Domínguez: Departamento de Medicina Interna, Hospital General de Zona No. 46, Instituto Mexicano del Seguro Social (IMSS), Villahermosa 86060, Mexico.
Isela Esther Juárez-Rojop: Centro de Investigación, División Académica de Ciencias de la Salud (DACS), Universidad Juárez Autónoma de Tabasco (UJAT), Villahermosa 86150, Mexico.
Carlos Alfonso Tovilla-Zárate: División Académica Multidisciplinaria de Comalcalco (DAMC), Universidad Juárez Autónoma de Tabasco (UJAT), Comalcalco 86650, Mexico. ORCID
Mirian Carolina Martínez-López: Centro de Investigación, División Académica de Ciencias de la Salud (DACS), Universidad Juárez Autónoma de Tabasco (UJAT), Villahermosa 86150, Mexico.
José D Méndez: Hospital de Cardiología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Ciudad de México 06703, Mexico.
We previously observed beneficial effects of native banana starch (NBS) with a high Resistant starch (RS) content on glycemic response in lean and obese participants. Here, we aimed to determine the effects of NBS and high-amylose maize starch (HMS) on glycemic control (GC) and glycemic variability (GV) in patients with Type 2 Diabetes (T2D) when treatments were matched for digestible starch content. In a randomized, crossover study, continuous glucose monitoring (CGM) was performed in 17 participants (aged 28-65 years, BMI ≥ 25 kg/m, both genders) consuming HMS, NBS, or digestible maize starch (DMS) for 4 days. HMS and NBS induced an increase in 24 h mean blood glucose during days 2 to 4 ( < 0.05). CONGA, GRADE, and J-index values were higher in HMS compared with DMS only at day 4 ( < 0.05). Yet, NBS intake provoked a reduction in fasting glycemia changes from baseline compared with DMS ( = 0.0074). In conclusion, under the experimental conditions, RS from two sources did not improve GC or GV. Future longer studies are needed to determine whether these findings were affected by a different baseline microbiota or other environmental factors.
