OpenLB
Open Library of Bioscience
Advanced Search
Polymers
Nov 27, 2021;13 (23):

Emerging Application of Magnetic Nanoparticles for Diagnosis and Treatment of Cancer.

Dalal A Alromi, Seyed Yazdan Madani, Alexander Seifalian
Author Information
  1. Dalal A Alromi: School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.
  2. Seyed Yazdan Madani: School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.
  3. Alexander Seifalian: Nanotechnology and Regenerative Medicine Commercialisation Centre (NanoRegMed Ltd.), London BioScience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK. ORCID
PMID: 34883649 DOI: 10.3390/polym13234146

Abstract

Cancer is a disease that has resulted in millions of deaths worldwide. The current conventional therapies utilized for the treatment of cancer have detrimental side effects. This led scientific researchers to explore new therapeutic avenues with an improved benefit to risk profile. Researchers have found nanoparticles, particles between the 1 and 100 nm range, to be encouraging tools in the area of cancer. Magnetic nanoparticles are one of many available nanoparticles at present. Magnetic nanoparticles have increasingly been receiving a considerable amount of attention in recent years owing to their unique magnetic properties, among many others. Magnetic nanoparticles can be controlled by an external magnetic field, signifying their ability to be site specific. The most popular approaches for the synthesis of magnetic nanoparticles are co-precipitation, thermal decomposition, hydrothermal, and polyol synthesis. The functionalization of magnetic nanoparticles is essential as it significantly increases their biocompatibility. The most utilized functionalization agents are comprised of polymers. The synthesis and functionalization of magnetic nanoparticles will be further explored in this review. The biomedical applications of magnetic nanoparticles investigated in this review are drug delivery, magnetic hyperthermia, and diagnosis. The diagnosis aspect focuses on the utilization of magnetic nanoparticles as contrast agents in magnetic resonance imaging. Clinical trials and toxicology studies relating to the application of magnetic nanoparticles for the diagnosis and treatment of cancer will also be discussed in this review.

Keywords

cancer diagnosis drug delivery functionalization magnetic hyperthermia magnetic nanoparticles synthesis toxicity

References

  1. Sci Rep. 2018 Feb 1;8(1):2082 [PMID: 29391477]
  2. Int J Mol Sci. 2013 Oct 25;14(11):21266-305 [PMID: 24232575]
  3. Part Fibre Toxicol. 2017 Apr 21;14(1):13 [PMID: 28431555]
  4. Biosci Rep. 2015 Nov 24;36(1):e00292 [PMID: 26604322]
  5. Molecules. 2020 Jul 10;25(14): [PMID: 32664325]
  6. Science. 2018 Feb 23;359(6378):866-867 [PMID: 29472467]
  7. Materials (Basel). 2020 Jun 05;13(11): [PMID: 32517085]
  8. Sensors (Basel). 2020 Apr 30;20(9): [PMID: 32365832]
  9. Environ Geochem Health. 2020 Jul;42(7):2277-2286 [PMID: 31894452]
  10. Nanomaterials (Basel). 2017 Aug 29;7(9): [PMID: 28850089]
  11. Int J Hyperthermia. 2008 Sep;24(6):467-74 [PMID: 18608593]
  12. Int J Mol Sci. 2020 Apr 01;21(7): [PMID: 32244817]
  13. Adv Drug Deliv Rev. 2009 Jun 21;61(6):467-77 [PMID: 19389434]
  14. Adv Healthc Mater. 2020 May;9(9):e1901058 [PMID: 32196144]
  15. Int J Nanomedicine. 2014 Mar 31;9:1641-53 [PMID: 24729700]
  16. Environ Sci Pollut Res Int. 2020 Jun;27(16):19214-19225 [PMID: 31884543]
  17. Bratisl Lek Listy. 2015;116(6):373-8 [PMID: 26084739]
  18. Breast. 2014 Apr;23(2):175-9 [PMID: 24484967]
  19. Eur J Surg Oncol. 2020 Dec;46(12):2195-2201 [PMID: 32631710]
  20. Cancers (Basel). 2021 Sep 12;13(18): [PMID: 34572810]
  21. Colloids Surf B Biointerfaces. 2021 Oct;206:111931 [PMID: 34171621]
  22. J Surg Oncol. 2016 Apr;113(5):501-7 [PMID: 26754343]
  23. Tetrahedron. 2011 Nov 4;67(44):8431-8444 [PMID: 22043109]
  24. Theranostics. 2020 Feb 18;10(8):3612-3621 [PMID: 32206111]
  25. Nat Rev Cancer. 2003 Apr;3(4):267-75 [PMID: 12671665]
  26. Mater Sci Eng C Mater Biol Appl. 2020 Feb;107:110314 [PMID: 31761184]
  27. Curr Pharm Des. 2017;23(20):2908-2917 [PMID: 28215155]
  28. ChemistryOpen. 2021 Mar;10(3):327-333 [PMID: 33590731]
  29. Chem Rev. 2012 Apr 11;112(4):2323-38 [PMID: 22216932]
  30. Nat Rev Drug Discov. 2008 Sep;7(9):771-82 [PMID: 18758474]
  31. Nanoscale Res Lett. 2008 Oct 02;3(11):397-415 [PMID: 21749733]
  32. Int J Nanomedicine. 2018 Mar 28;13:1899-1915 [PMID: 29636608]
  33. Mater Today (Kidlington). 2011 Jul;14(7-8):330-338 [PMID: 22389583]
  34. CA Cancer J Clin. 2021 May;71(3):209-249 [PMID: 33538338]
  35. Comput Methods Programs Biomed. 2021 Jan;198:105778 [PMID: 33039920]
  36. Nanomedicine (Lond). 2016 Aug;11(16):2215-32 [PMID: 27480599]
  37. RMD Open. 2018 Jun 20;4(1):e000728 [PMID: 29955387]
  38. Curr Med Chem. 2010;17(27):3120-41 [PMID: 20629620]
  39. Contrast Media Mol Imaging. 2020 May 6;2020:4764985 [PMID: 32454803]
  40. Nanomedicine. 2010 Apr;6(2):214-26 [PMID: 19699322]
  41. Mater Sci Eng C Mater Biol Appl. 2020 May;110:110695 [PMID: 32204010]
  42. Top Curr Chem (Cham). 2020 May 7;378(3):40 [PMID: 32382832]
  43. Chem Soc Rev. 2018 Jul 17;47(14):5187-5233 [PMID: 29901663]
  44. Radiographics. 2015 Oct;35(6):1738-50 [PMID: 26466182]
  45. Quant Imaging Med Surg. 2018 Oct;8(9):957-970 [PMID: 30505724]
  46. Adv Healthc Mater. 2021 Jan;10(1):e2001451 [PMID: 33135398]
  47. Adv Healthc Mater. 2014 Feb;3(2):160-75 [PMID: 24497448]
  48. Asia Pac J Clin Oncol. 2016 Mar;12(1):13-21 [PMID: 26663873]
  49. Int J Nanomedicine. 2008;3(2):169-80 [PMID: 18686777]
  50. J Surg Oncol. 2019 Dec;120(8):1391-1396 [PMID: 31667855]
  51. Adv Drug Deliv Rev. 2008 Aug 17;60(11):1252-1265 [PMID: 18558452]
  52. BMC Med Imaging. 2020 May 27;20(1):58 [PMID: 32460834]
  53. Biomaterials. 2013 May;34(14):3647-57 [PMID: 23415642]
  54. Int J Nanomedicine. 2016 Oct 17;11:5371-5379 [PMID: 27799764]
  55. Crit Rev Anal Chem. 2022;52(2):231-249 [PMID: 32715777]
  56. Biomed Opt Express. 2012 Oct 1;3(10):2500-9 [PMID: 23082291]
  57. Nanomedicine (Lond). 2011 Jun;6(4):715-28 [PMID: 21718180]
  58. Biomaterials. 2011 Mar;32(7):1890-905 [PMID: 21167595]
  59. Nat Mater. 2008 Jul;7(7):588-95 [PMID: 18500347]
  60. Nano Lett. 2010 Sep 8;10(9):3223-30 [PMID: 20726522]
  61. Int J Cardiol. 2014 May 1;173(2):184-9 [PMID: 24613367]
  62. Science. 2003 Oct 31;302(5646):830-4 [PMID: 14593169]
  63. Int J Nanomedicine. 2014 Apr 17;9:1919-29 [PMID: 24790434]
  64. Int J Mol Sci. 2014 Nov 17;15(11):21253-69 [PMID: 25407529]
  65. Nanoscale Res Lett. 2012 Feb 21;7(1):144 [PMID: 22348683]
  66. Life Sci. 2019 Mar 1;220:156-161 [PMID: 30716338]
  67. Nephrol Dial Transplant. 2018 Sep 1;33(suppl_2):ii41-ii50 [PMID: 30137583]
  68. Adv Mater. 2019 Feb;31(8):e1804567 [PMID: 30600553]
  69. Radiology. 1990 Jun;175(3):621-8 [PMID: 2343107]
  70. Artif Cells Nanomed Biotechnol. 2016;44(2):722-34 [PMID: 25435409]
  71. Nanotechnology. 2008 Aug 20;19(33):335601 [PMID: 19701448]
  72. Int J Mol Sci. 2018 Jul 31;19(8): [PMID: 30065155]
  73. Chem Rev. 2008 Jun;108(6):2064-110 [PMID: 18543879]
  74. Nanoscale Res Lett. 2019 May 30;14(1):188 [PMID: 31147786]
  75. Nanomaterials (Basel). 2018 Oct 09;8(10): [PMID: 30304823]
  76. Eur Urol. 2013 Dec;64(6):953-60 [PMID: 23916692]
  77. Nanotechnol Sci Appl. 2016 Aug 19;9:49-67 [PMID: 27578966]
  78. Pharmacol Ther. 2010 Nov;128(2):324-35 [PMID: 20705093]
  79. J Control Release. 2010 Nov 20;148(1):122-127 [PMID: 20547192]
  80. J Biosci Bioeng. 2005 Jul;100(1):1-11 [PMID: 16233845]
  81. Nat Biotechnol. 2008 Jan;26(1):83-90 [PMID: 18157119]
  82. Cephalalgia. 2019 Oct;39(11):1407-1420 [PMID: 31104505]
  83. Dalton Trans. 2011 Jun 28;40(24):6315-43 [PMID: 21359397]
  84. Int J Nanomedicine. 2014 Mar 12;9:1393-402 [PMID: 24648736]
  85. Appl Biochem Biotechnol. 2011 Nov;165(5-6):1178-87 [PMID: 21847590]
  86. Chem Rev. 2018 Jul 25;118(14):6766-6843 [PMID: 29969244]
  87. Biosens Bioelectron. 2009 Mar 15;24(7):2260-3 [PMID: 19056254]
  88. Small. 2008 Mar;4(3):334-41 [PMID: 18273855]
  89. ACS Nano. 2018 Apr 24;12(4):3699-3713 [PMID: 29570277]
  90. Nanotechnology. 2019 Dec 13;30(50):502003 [PMID: 31491782]
  91. Angew Chem Int Ed Engl. 2009;48(5):872-97 [PMID: 19142939]
  92. Adv Mater. 2020 Nov;32(45):e2003712 [PMID: 33002227]
  93. J Cell Physiol. 2019 Aug;234(8):12615-12624 [PMID: 30536886]
  94. Part Fibre Toxicol. 2016 Apr 30;13(1):22 [PMID: 27138375]
  95. Drug Metab Rev. 2020 Feb;52(1):157-184 [PMID: 31834823]
  96. Methods Mol Biol. 2017;1570:47-71 [PMID: 28238129]
  97. J Control Release. 2020 Dec 10;328:776-791 [PMID: 32920079]
  98. Int J Environ Res Public Health. 2015 Jul 17;12(7):8263-80 [PMID: 26193294]
  99. Nanomaterials (Basel). 2018 Jun 03;8(6): [PMID: 29865277]
  100. Front Pharmacol. 2017 Mar 28;8:154 [PMID: 28400730]
  101. Int J Biol Macromol. 2018 Dec;120(Pt B):2530-2544 [PMID: 30201561]
  102. J Mater Chem B. 2021 Mar 4;9(8):1965-1979 [PMID: 33595050]
  103. J Stroke Cerebrovasc Dis. 2017 Oct;26(10):2055-2064 [PMID: 28774792]
  104. RSC Adv. 2019 Aug 13;9(43):25094-25106 [PMID: 35528662]
  105. Basic Res Cardiol. 2008 Mar;103(2):122-30 [PMID: 18324368]
  106. Nanotechnol Sci Appl. 2008 Sep 19;1:17-32 [PMID: 24198458]
  107. Nat Rev Cancer. 2005 Nov;5(11):845-56 [PMID: 16239904]
  108. Int J Mol Med. 2016 Nov;38(5):1319-1326 [PMID: 27666161]
  109. Anal Chem. 2019 Nov 19;91(22):14159-14169 [PMID: 31566353]
  110. Antibiotics (Basel). 2018 Jun 09;7(2): [PMID: 29890753]
  111. Materials (Basel). 2019 Feb 02;12(3): [PMID: 30717431]
  112. J Nat Sci Biol Med. 2015 Jul-Dec;6(2):335-9 [PMID: 26283824]
  113. Scand J Surg. 2018 Jun;107(2):130-137 [PMID: 29132268]
  114. Magn Reson Imaging. 2016 Feb;34(2):152-8 [PMID: 26518061]
  115. Int J Mol Sci. 2020 Oct 13;21(20): [PMID: 33066271]
  116. Pol J Radiol. 2015 Jan 25;80:40-50 [PMID: 25628772]
  117. Chem Rev. 2009 Jul;109(7):2859-61 [PMID: 19583428]
  118. Int J Nanomedicine. 2016 May 12;11:2021-37 [PMID: 27274233]
  119. Nanoscale Res Lett. 2015 May 13;10:217 [PMID: 26034415]
  120. Adv Healthc Mater. 2017 Dec;6(23): [PMID: 28990364]
  121. Mater Sci Eng C Mater Biol Appl. 2017 Oct 1;79:901-916 [PMID: 28629096]
  122. World Neurosurg. 2018 Sep;117:e698-e704 [PMID: 29960096]
  123. J Mater Sci Mater Med. 2004 Apr;15(4):493-6 [PMID: 15332623]
  124. Talanta. 2021 May 1;226:122108 [PMID: 33676664]
Journal Article Review

Word Cloud

Created with Highcharts 10.0.0nanoparticlesmagneticcancerMagneticsynthesisfunctionalizationdiagnosisreviewCancerutilizedtreatmentmanyagentswilldrugdeliveryhyperthermiadiseaseresultedmillionsdeathsworldwidecurrentconventionaltherapiesdetrimentalsideeffectsledscientificresearchersexplorenewtherapeuticavenuesimprovedbenefitriskprofileResearchersfoundparticles1100nmrangeencouragingtoolsareaoneavailablepresentincreasinglyreceivingconsiderableamountattentionrecentyearsowinguniquepropertiesamongotherscancontrolledexternalfieldsignifyingabilitysitespecificpopularapproachesco-precipitationthermaldecompositionhydrothermalpolyolessentialsignificantlyincreasesbiocompatibilitycomprisedpolymersexploredbiomedicalapplicationsinvestigatedaspectfocusesutilizationcontrastresonanceimagingClinicaltrialstoxicologystudiesrelatingapplicationalsodiscussedEmergingApplicationNanoparticlesDiagnosisTreatmenttoxicity

Similar Articles

Cited By