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Advanced science (Weinheim, Baden-Wurttemberg, Germany)
02, 2022;9 (4): e2103388.

A Survey of Chinese Pig Farms and Human Healthcare Isolates Reveals Separate Human and Animal Methicillin-Resistant Staphylococcus aureus Populations.

Geng Zou, Marta Matuszewska, Ming Jia, Jianwei Zhou, Xiaoliang Ba, Juan Duan, Caishi Zhang, Jian Zhao, Meng Tao, Jingyan Fan, Xiangming Zhang, Wenping Jin, Tianpen Cui, Xianyu Zeng, Min Jia, Xiaojuan Qian, Chao Huang, Wenxiao Zhuo, Zhiming Yao, Lijun Zhang, Shaowen Li, Lu Li, Qi Huang, Bin Wu, Huanchun Chen, Alexander W Tucker, Andrew J Grant, Mark A Holmes, Rui Zhou
Author Information
  1. Geng Zou: State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University College of Veterinary Medicine, Wuhan, 430070, China.
  2. Marta Matuszewska: Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK.
  3. Ming Jia: State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University College of Veterinary Medicine, Wuhan, 430070, China.
  4. Jianwei Zhou: State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University College of Veterinary Medicine, Wuhan, 430070, China.
  5. Xiaoliang Ba: Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK.
  6. Juan Duan: State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University College of Veterinary Medicine, Wuhan, 430070, China.
  7. Caishi Zhang: Jianli People's Hospital, Jianli, 433300, China.
  8. Jian Zhao: State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University College of Veterinary Medicine, Wuhan, 430070, China.
  9. Meng Tao: State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University College of Veterinary Medicine, Wuhan, 430070, China.
  10. Jingyan Fan: State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University College of Veterinary Medicine, Wuhan, 430070, China.
  11. Xiangming Zhang: Wuhan Third Hospital, Wuhan, 430060, China.
  12. Wenping Jin: Wuhan Third Hospital, Wuhan, 430060, China.
  13. Tianpen Cui: Wuhan First Hospital, Wuhan, 430014, China.
  14. Xianyu Zeng: Wuhan First Hospital, Wuhan, 430014, China.
  15. Min Jia: Wuhan First Hospital, Wuhan, 430014, China.
  16. Xiaojuan Qian: Huangmei People's Hospital, Huangmei, 435500, China.
  17. Chao Huang: State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University College of Veterinary Medicine, Wuhan, 430070, China.
  18. Wenxiao Zhuo: State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University College of Veterinary Medicine, Wuhan, 430070, China.
  19. Zhiming Yao: State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University College of Veterinary Medicine, Wuhan, 430070, China.
  20. Lijun Zhang: State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University College of Veterinary Medicine, Wuhan, 430070, China.
  21. Shaowen Li: State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University College of Veterinary Medicine, Wuhan, 430070, China.
  22. Lu Li: State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University College of Veterinary Medicine, Wuhan, 430070, China.
  23. Qi Huang: State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University College of Veterinary Medicine, Wuhan, 430070, China.
  24. Bin Wu: State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University College of Veterinary Medicine, Wuhan, 430070, China.
  25. Huanchun Chen: State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University College of Veterinary Medicine, Wuhan, 430070, China.
  26. Alexander W Tucker: Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK.
  27. Andrew J Grant: Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK.
  28. Mark A Holmes: Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK.
  29. Rui Zhou: State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University College of Veterinary Medicine, Wuhan, 430070, China. ORCID
PMID: 34894204 DOI: 10.1002/advs.202103388

Abstract

There has been increasing concern that the overuse of antibiotics in livestock farming is contributing to the burden of antimicrobial resistance in people. Farmed animals in Europe and North America, particularly pigs, provide a reservoir for livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA ST398 lineage) found in people. This study is designed to investigate the contribution of MRSA from Chinese pig farms to human infection. A collection of 483 MRSA are isolated from 55 farms and 4 hospitals in central China, a high pig farming density area. CC9 MRSA accounts for 97.2% of all farm isolates, but is not present in hospital isolates. ST398 isolates are found on farms and hospitals, but none of them formed part of the "LA-MRSA ST398 lineage" present in Europe and North America. The hospital ST398 MRSA isolate form a clade that is clearly separate from the farm ST398 isolates. Despite the presence of high levels of MRSA found on Chinese pig farms, the authors find no evidence of them spilling over to the human population. Nevertheless, the ST398 MRSA obtained from hospitals appear to be part of a widely distributed lineage in China. The new animal-adapted ST398 lineage that has emerged in China is of concern.

Keywords

ST398 hospitals methicillin-resistant Staphylococcus aureus pig farms population structures

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Grants

  1. 81661138003/National Natural Science Foundation of China
  2. MR/P007201/1/UK Medical Research Council

MeSH Term

Animal Population Groups
Animals
China
Farms
Humans
Livestock
Methicillin-Resistant Staphylococcus aureus
Staphylococcal Infections
Swine
Swine Diseases
Journal Article Multicenter Study Research Support, Non-U.S. Gov't
Article has an altmetric score of 3

Word Cloud

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