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Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
03, 2022;14 (2): e1769.

Catalytic antimicrobial therapy using nanozymes.

Qian Wang, Jing Jiang, Lizeng Gao
Author Information
  1. Qian Wang: CAS Engineering Laboratory for Nanozyme, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
  2. Jing Jiang: CAS Engineering Laboratory for Nanozyme, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
  3. Lizeng Gao: CAS Engineering Laboratory for Nanozyme, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. ORCID
PMID: 34939348 DOI: 10.1002/wnan.1769

Abstract

Nanozymes are nanomaterials with enzyme-like characteristics, which catalyze the conversion of enzyme substrates and follow enzymatic kinetics under physiological conditions. As a new generation of artificial enzymes, nanozymes provide alternative approaches for those upon enzymatic catalysis. Compared with natural enzymes, nanozymes have the advantages of simple preparation, good stability and low cost, which makes nanozymes promising for application in many fields, such as antimicrobial infection treatment. Many studies have reported that nanozymes are capable of killing a number of pathogenic bacteria with resistance, fungi as well as viruses, and have shown great curative effects for diseases caused by these pathogens. Herein, we summarize the application of nanozymes for antibacterial, antiviral, and antifungal therapies and outline the issues needing resolution in the future. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease.

Keywords

antibacterial antifungal antiviral catalytic therapy nanozymes

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MeSH Term

Anti-Bacterial Agents
Anti-Infective Agents
Catalysis
Nanomedicine
Nanostructures

Chemicals

Anti-Bacterial Agents
Anti-Infective Agents
Journal Article Research Support, Non-U.S. Gov't Review
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Created with Highcharts 10.0.0nanozymesenzymaticenzymesapplicationantimicrobialantibacterialantiviralantifungaltherapyNanozymesnanomaterialsenzyme-likecharacteristicscatalyzeconversionenzymesubstratesfollowkineticsphysiologicalconditionsnewgenerationartificialprovidealternativeapproachesuponcatalysisComparednaturaladvantagessimplepreparationgoodstabilitylowcostmakespromisingmanyfieldsinfectiontreatmentManystudiesreportedcapablekillingnumberpathogenicbacteriaresistancefungiwellvirusesshowngreatcurativeeffectsdiseasescausedpathogensHereinsummarizetherapiesoutlineissuesneedingresolutionfuturearticlecategorizedunder:TherapeuticApproachesDrugDiscovery>NanomedicineInfectiousDiseaseCatalyticusingcatalytic

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