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Cell regeneration (London, England)
Jan 04, 2022;11 (1): 1.

Modeling human neurodevelopmental diseases with brain organoids.

Xiaoxiang Lu, Jiajie Yang, Yangfei Xiang
Author Information
  1. Xiaoxiang Lu: School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
  2. Jiajie Yang: School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
  3. Yangfei Xiang: School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. xiangyf@shanghaitech.edu.cn. ORCID
PMID: 34982276 DOI: 10.1186/s13619-021-00103-6

Abstract

Studying the etiology of human neurodevelopmental diseases has long been a challenging task due to the brain's complexity and its limited accessibility. Human pluripotent stem cells (hPSCs)-derived brain organoids are capable of recapitulating various features and functionalities of the human brain, allowing the investigation of intricate pathogenesis of developmental abnormalities. Over the past years, brain organoids have facilitated identifying disease-associated phenotypes and underlying mechanisms for human neurodevelopmental diseases. Integrating with more cutting-edge technologies, particularly gene editing, brain organoids further empower human disease modeling. Here, we review the latest progress in modeling human neurodevelopmental disorders with brain organoids.

Keywords

Brain organoids Disease modeling Gene editing Neurodevepmental diseases Stem cells

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