A stochastic inventory model of COVID-19 and robust, real-time identification of carriers at large and infection rate via asymptotic laws.

Christiana Tsiligianni, Aristeides Tsiligiannis, Christos Tsiliyannis
Author Information
  1. Christiana Tsiligianni: ANION Environmental Ltd, 26 Lykoudi Str., Athens GR 11141, Greece.
  2. Aristeides Tsiligiannis: ANION Environmental Ltd, 26 Lykoudi Str., Athens GR 11141, Greece.
  3. Christos Tsiliyannis: ANION Environmental Ltd, 26 Lykoudi Str., Athens GR 11141, Greece.

Abstract

A critical operations management problem in the ongoing COVID-19 pandemic is cognizance of (a) the number of all carriers at large (CaL) conveying the SARS-CoV-2, including asymptomatic ones and (b) the infection rate (IR). Both are random and unobservable, affecting the spread of the disease, patient arrivals to health care units (HCUs) and the number of deaths. A novel, inventory perspective of COVID-19 is proposed, with random inflow, random losses and retrials (recurrent cases) and delayed/distributed exit, with randomly varying fractions of the exit distribution. A minimal construal, it enables representation of COVID-19 evolution with close fit of national incidence profiles, including single and multiple pattern outbreaks, oscillatory, periodic or non-periodic evolution, followed by retraction, leveling off, or strong resurgence. Furthermore, based on asymptotic laws, the minimum number of variables that must be monitored for identifying CaL and IR is determined and a real-time identification method is presented. The method is data-driven, utilizing the entry rate to HCUs and scaled, or dimensionless variables, including the mean residence time of symptomatic carriers in CaL and the mean residence time in CaL of patients entering HCUs. As manifested by several robust case studies of national COVID-19 incidence profiles, it provides efficient identification in real-time under unbiased monitoring error, without relying on any model. The propagation factor, a stochastic process, is reconstructed from the identified trajectories of CaL and IR, enabling evaluation of control measures. The results are useful towards the design of policies restricting COVID-19 and encumbrance to HCUs and mitigating economic contraction.

Keywords

References

  1. Annu Rev Control. 2021;51:525-539 [PMID: 33362428]
  2. J Thorac Dis. 2020 Mar;12(3):165-174 [PMID: 32274081]
  3. Annu Rev Control. 2020;50:373-393 [PMID: 33024411]
  4. Int J Surg. 2020 Jun;78:185-193 [PMID: 32305533]
  5. Ind Eng Chem Res. 2021 Feb 02;60(11):4251-4260 [PMID: 37556235]
  6. BMC Med. 2019 Aug 22;17(1):164 [PMID: 31438953]
  7. Math Biosci Eng. 2020 Mar 16;17(4):2792-2804 [PMID: 32987496]
  8. Sci Rep. 2020 Jul 1;10(1):10711 [PMID: 32612204]
  9. BMC Public Health. 2021 Mar 29;21(1):615 [PMID: 33781260]
  10. Rev Med Virol. 2004 Sep-Oct;14(5):275-88 [PMID: 15334536]
  11. BMC Res Notes. 2020 Jul 23;13(1):352 [PMID: 32703315]
  12. Infect Dis Model. 2017 Mar 11;2(2):128-142 [PMID: 29928733]
  13. Int J Infect Dis. 2020 Jun;95:311-315 [PMID: 32234343]
  14. J Med Internet Res. 2015 Jul 08;17(7):e169 [PMID: 26156032]
  15. PLoS One. 2020 Mar 31;15(3):e0230405 [PMID: 32231374]
  16. Hellenic J Cardiol. 2020 Jan - Feb;61(1):42-45 [PMID: 32251729]
  17. Sci Rep. 2021 Apr 14;11(1):8191 [PMID: 33854079]
  18. ISA Trans. 2022 May;124:197-214 [PMID: 33309260]
  19. IFAC Pap OnLine. 2021;54(15):251-256 [PMID: 38620923]
  20. Math Biosci. 2007 Aug;208(2):571-89 [PMID: 17303188]
  21. Biosci Trends. 2020 May 21;14(2):134-138 [PMID: 32188819]
  22. Br Med J. 1915 Mar 27;1(2830):546-7 [PMID: 20767555]
  23. Eur J Oper Res. 2023 Jan 1;304(1):339-352 [PMID: 33776195]
  24. J Theor Biol. 2021 Mar 7;512:110568 [PMID: 33385403]
  25. J Math Biol. 2000 Jun;40(6):525-40 [PMID: 10945647]
  26. Int J Infect Dis. 2020 Apr;93:211-216 [PMID: 32145465]
  27. Bull Math Biol. 2006 Apr;68(3):615-26 [PMID: 16794947]
  28. Infect Dis Model. 2020;5:282-292 [PMID: 32292868]
  29. PLoS One. 2020 Mar 19;15(3):e0230548 [PMID: 32191764]
  30. Annu Rev Control. 2020;50:361-372 [PMID: 33132739]
  31. Int J Infect Dis. 2020 Mar;92:214-217 [PMID: 32007643]
  32. Trends Microbiol. 2007 Sep;15(9):408-16 [PMID: 17698361]
  33. Environ Int. 2016 Jan;86:14-23 [PMID: 26479830]
  34. Nat Med. 2020 Jun;26(6):855-860 [PMID: 32322102]
  35. Epidemics. 2018 Mar;22:62-70 [PMID: 27913131]
  36. PLoS Curr. 2015 Jan 21;7: [PMID: 25685633]
  37. Nat Commun. 2020 Nov 11;11(1):5710 [PMID: 33177507]
  38. Math Biosci. 2002 Nov-Dec;180:29-48 [PMID: 12387915]
  39. Infect Dis Model. 2016 Dec 12;2(1):12-20 [PMID: 29928726]
  40. Epidemiol Infect. 2006 Apr;134(2):223-30 [PMID: 16490124]
  41. Math Biosci Eng. 2018 Feb 1;15(1):275-298 [PMID: 29161836]
  42. Eur J Oper Res. 2023 Jan 1;304(1):25-41 [PMID: 34219901]
  43. Nat Commun. 2020 Nov 4;11(1):5576 [PMID: 33149128]
  44. Infect Control Hosp Epidemiol. 2020 Jul;41(7):857-859 [PMID: 32268929]
  45. J Microbiol Immunol Infect. 2020 Jun;53(3):404-412 [PMID: 32173241]
  46. J R Soc Interface. 2005 Sep 22;2(4):295-307 [PMID: 16849187]
  47. Epidemics. 2018 Mar;22:56-61 [PMID: 28038870]
  48. Chaos Solitons Fractals. 2020 Sep;138:109937 [PMID: 32834573]
  49. Eur J Oper Res. 2022 Jun 1;299(2):631-641 [PMID: 34584339]

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