Pulmonary nodular lymphoid hyperplasia presenting as multifocal subsolid nodules: A case report and literature review.

Yoon Jin Cha, Duk Hwan Moon, Ji Hyun Park, Sungsoo Lee, Ji Ae Choi, Tae Hoon Kim, Chul Hwan Park
Author Information
  1. Yoon Jin Cha: Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  2. Duk Hwan Moon: Department of Thoracic and Cardiovascular Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  3. Ji Hyun Park: Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  4. Sungsoo Lee: Department of Thoracic and Cardiovascular Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  5. Ji Ae Choi: Department of Radiology and the Research Institute of Radiological Science, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  6. Tae Hoon Kim: Department of Radiology and the Research Institute of Radiological Science, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  7. Chul Hwan Park: Department of Radiology and the Research Institute of Radiological Science, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Abstract

Pulmonary nodular lymphoid hyperplasia (PNLH) is a rare, benign lymphoproliferative disease, which is characterized by nonclonal lymphoproliferation. PNLH is usually asymptomatic and usually detected incidentally on imaging studies. Common imaging findings include a solitary nodule, multiple nodules, or focal consolidation. Atypically, PNLH may present with persistent subsolid nodules, mimicking adenocarcinoma. Here, we report a rare case of PNLH presenting as multifocal subsolid nodules in both lower lobes. During follow-up, persistency and growth of the subsolid nodules suggested the possibility of malignancy. Wedge resection was performed bilaterally, and PNLH was confirmed on pathological examination.

Keywords

References

  1. Semin Respir Crit Care Med. 2016 Jun;37(3):406-20 [PMID: 27231864]
  2. Arch Pathol Lab Med. 2019 Sep;143(9):1149-1153 [PMID: 30720334]
  3. Am J Surg Pathol. 2013 May;37(5):699-709 [PMID: 23588364]
  4. Respiration. 2017;94(2):157-175 [PMID: 28609772]
  5. Am J Respir Crit Care Med. 2013 Sep 15;188(6):733-48 [PMID: 24032382]
  6. J Pathol Transl Med. 2018 Jul;52(4):211-218 [PMID: 29902913]
  7. Am J Surg Pathol. 2000 Apr;24(4):587-97 [PMID: 10757408]
  8. Hum Pathol. 1983 Oct;14(10):857-67 [PMID: 6352457]
  9. Radiographics. 2016 Jan-Feb;36(1):53-70 [PMID: 26761531]
  10. Br J Radiol. 2012 Jul;85(1015):848-64 [PMID: 22745203]
  11. Hum Pathol. 2017 Jan;59:80-86 [PMID: 27720730]
  12. Ann Transl Med. 2019 Feb;7(3):43 [PMID: 30906747]
  13. Am J Surg Pathol. 2002 Jan;26(1):76-81 [PMID: 11756772]

Word Cloud

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