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Biologia futura
Mar, 2022;73 (1): 55-69.

Diet-derived small molecules (nutraceuticals) inhibit cellular proliferation by interfering with key oncogenic pathways: an overview of experimental evidence in cancer chemoprevention.

Mohammad Fahad Ullah, Aamir Ahmad, Showket H Bhat, Faisel M Abuduhier, Syed Khalid Mustafa, Shazia Usmani
Author Information
  1. Mohammad Fahad Ullah: Prince Fahd Research Chair, Department of Medical Laboratory Technology, Faculty of Applied Medical Science, University of Tabuk, Tabuk, Saudi Arabia. m.ullah@ut.edu.sa. ORCID
  2. Aamir Ahmad: University of Alabama at Birmingham, Birmingham, AL, USA.
  3. Showket H Bhat: Prince Fahd Research Chair, Department of Medical Laboratory Technology, Faculty of Applied Medical Science, University of Tabuk, Tabuk, Saudi Arabia.
  4. Faisel M Abuduhier: Prince Fahd Research Chair, Department of Medical Laboratory Technology, Faculty of Applied Medical Science, University of Tabuk, Tabuk, Saudi Arabia.
  5. Syed Khalid Mustafa: Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia.
  6. Shazia Usmani: Faculty of Pharmacy, Integral University, Lucknow, India.
PMID: 35040098 DOI: 10.1007/s42977-022-00110-x

Abstract

Discouraging statistics of cancer disease has projected an increase in the global cancer burden from 19.3 to 28.4 million incidences annually within the next two decades. Currently, there has been a revival of interest in nutraceuticals with evidence of pharmacological properties against human diseases including cancer. Diet is an integral part of lifestyle, and it has been proposed that an estimated one-third of human cancers can be prevented through appropriate lifestyle modification including dietary habits; hence, it is considered significant to explore the pharmacological benefits of these agents, which are easily accessible and have higher safety index. Accordingly, an impressive embodiment of evidence supports the concept that the dietary factors are critical modulators to prevent, retard, block, or reverse carcinogenesis. Such an action reflects the ability of these molecules to interfere with multitude of pathways to subdue and neutralize several oncogenic factors and thereby keep a restraint on neoplastic transformations. This review provides a series of experimental evidence based on the current literature to highlight the translational potential of nutraceuticals for the prevention of the disease through consumption of enriched diets and its efficacious management by means of novel interventions. Specifically, this review provides the current understanding of the chemopreventive pharmacology of nutraceuticals such as cucurbitacins, morin, fisetin, curcumin, luteolin and garcinol toward their potential as anticancer agents.

Keywords

Apoptosis Cancer Chemoprevention Nutraceuticals Signaling pathways

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MeSH Term

Carcinogenesis
Cell Proliferation
Chemoprevention
Diet
Dietary Supplements
Humans
Neoplasms
Journal Article Review

Word Cloud

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