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Future medicinal chemistry
03, 2022;14 (5): 343-362.

Antibacterial pyrazoles: tackling resistant bacteria.

Mohammad A Alam
Author Information
  1. Mohammad A Alam: Department of Chemistry & Physics, College of Sciences & Mathematics, Arkansas State University, Jonesboro, AR 72401, USA. ORCID
PMID: 35050719 DOI: 10.4155/fmc-2021-0275

Abstract

Bacterial resistance to antibiotics threatens our progress in healthcare, modern medicine, food production and ultimately life expectancy. Antibiotic resistance is a global concern, which spreads rapidly across borders and continents due to rapid travel of people, animals and goods. Derivatives of metabolically stable pyrazole nucleus are known for their wide range of pharmacological properties, including antibacterial activities. This review highlights recent reports of pyrazole derivatives targeting different bacterial strains focusing on the drug-resistant variants. pyrazole derivatives target different metabolic pathways of both Gram-positive and Gram-negative bacteria.

Keywords

Acinetobacter baumannii ESKAPE pathogens MRSA antibacterial antibiotics antimicrobials bacterial resistance drug-resistant pyrazole

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Grants

  1. P20 GM103429/NIGMS NIH HHS

MeSH Term

Alkyl and Aryl Transferases
Anti-Bacterial Agents
Cell Wall
DNA Gyrase
Drug Resistance, Multiple, Bacterial
Gram-Negative Bacteria
Gram-Positive Bacteria
Pyrazoles
Tetrahydrofolate Dehydrogenase

Chemicals

Anti-Bacterial Agents
Pyrazoles
Tetrahydrofolate Dehydrogenase
Alkyl and Aryl Transferases
undecaprenyl pyrophosphate synthetase
DNA Gyrase
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 2

Word Cloud

Created with Highcharts 10.0.0resistancepyrazoleantibioticsantibacterialderivativesdifferentbacterialdrug-resistantbacteriaBacterialthreatensprogresshealthcaremodernmedicinefoodproduction andultimatelylifeexpectancyAntibioticglobalconcernspreadsrapidlyacrossborderscontinentsduerapid travelpeopleanimalsgoodsDerivativesmetabolicallystablenucleusknownwiderangepharmacologicalpropertiesincludingactivitiesThis reviewhighlightsrecentreportstargetingstrainsfocusingvariantsPyrazoletargetmetabolicpathwaysGram-positiveGram-negativeAntibacterialpyrazoles:tacklingresistantAcinetobacterbaumanniiESKAPEpathogensMRSAantimicrobials

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