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12 29, 2021;14 (1):

Host Non-Coding RNA Regulates Influenza A Virus Replication.

Yuejiao Liao, Shouqing Guo, Geng Liu, Zhenyu Qiu, Jiamin Wang, Di Yang, Xiaojing Tian, Ziling Qiao, Zhongren Ma, Zhenbin Liu
Author Information
  1. Yuejiao Liao: Gansu Tech Innovation Center of Animal Cell, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China.
  2. Shouqing Guo: Gansu Tech Innovation Center of Animal Cell, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China.
  3. Geng Liu: Gansu Tech Innovation Center of Animal Cell, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China.
  4. Zhenyu Qiu: Gansu Tech Innovation Center of Animal Cell, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China.
  5. Jiamin Wang: Gansu Tech Innovation Center of Animal Cell, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China.
  6. Di Yang: Gansu Tech Innovation Center of Animal Cell, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China.
  7. Xiaojing Tian: Life Science and Engineering College, Northwest Minzu University, Lanzhou 730030, China. ORCID
  8. Ziling Qiao: Gansu Tech Innovation Center of Animal Cell, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China.
  9. Zhongren Ma: Gansu Tech Innovation Center of Animal Cell, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China.
  10. Zhenbin Liu: Gansu Tech Innovation Center of Animal Cell, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China.
PMID: 35062254 DOI: 10.3390/v14010051

Abstract

Outbreaks of influenza, caused by the influenza A virus (IAV), occur almost every year in various regions worldwide, seriously endangering human health. Studies have shown that host non-coding RNA is an important regulator of host-virus interactions in the process of IAV infection. In this paper, we comprehensively analyzed the research progress on host non-coding RNAs with regard to the regulation of IAV replication. According to the regulation mode of host non-coding RNAs, the signal pathways involved, and the specific target genes, we found that a large number of host non-coding RNAs directly targeted the PB1 and PB2 proteins of IAV. Nonstructural protein 1 and other key genes regulate the replication of IAV and indirectly participate in the regulation of the retinoic acid-induced gene I-like receptor signaling pathway, toll-like receptor signaling pathway, Janus kinase signal transducer and activator of transcription signaling pathway, and other major intracellular viral response signaling pathways to regulate the replication of IAV. Based on the above findings, we mapped the regulatory network of host non-coding RNAs in the innate immune response to the influenza virus. These findings will provide a more comprehensive understanding of the function and mechanism of host non-coding RNAs in the cellular anti-virus response as well as clues to the mechanism of cell-virus interactions and the discovery of antiviral drug targets.

Keywords

IAV antiviral innate immune response circRNA interferon lncRNA miRNA

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MeSH Term

Antiviral Agents
Cell Cycle
Host-Pathogen Interactions
Humans
Immunity, Innate
Influenza A virus
Influenza, Human
MicroRNAs
RNA, Circular
RNA, Untranslated
Signal Transduction
Virus Replication

Chemicals

Antiviral Agents
MicroRNAs
RNA, Circular
RNA, Untranslated
Journal Article Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 1

Word Cloud

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