Role of Anopheles Mosquitoes in Cache Valley Virus Lineage Displacement, New York, USA.
Constentin Dieme, Kiet A Ngo, Shaun Tyler, Joseph G Maffei, Steven D Zink, Alan P Dupuis, Cheri A Koetzner, Chelsea Shultis, Jessica Stout, Anne F Payne, P Bryon Backenson, Lili Kuo, Michael A Drebot, Alexander T Ciota, Laura D Kramer
Cache Valley Virus (CVV) is a mosquitoborne virus that infects livestock An.humans. We report results of surveillance for CVV in New York, USA, during 2000-2016; full-genome analysis of selected CVV isolates from sheep, horse, humans, An. mosquitoes from New York An. Canada; An. phenotypic characterization of selected strains. We calculated infection rates by using the maximum-likelihood estimation method by year, region, month, An. mosquito species. The highest maximum-likelihood estimations were for Anopheles spp. mosquitoes. Our phylogenetic analysis identified 2 lineages An. found evidence of segment reassortment. Furthermore, our data suggest displacement of CVV lineage 1 by lineage 2 in New York An. Canada. Finally, we showed increased vector competence of An. quadrimaculatus mosquitoes for lineage 2 strains of CVV compared with lineage 1 strains.
