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Sleep science (Sao Paulo, Brazil)
2021 Apr-Jun;14 (Spec 2): 167-173.

Strain specific behavioral and physiological responses to constant light in male CBA/J and CBA/CaJ mice.

Hannah V Deane, Holly A Concepcion, Avery E Gatewood, Janessa Quintana, Joseph A Seggio
Author Information
  1. Hannah V Deane: Bridgewater State University, Department of Biological Sciences - Bridgewater - MA - United States.
  2. Holly A Concepcion: Bridgewater State University, Department of Biological Sciences - Bridgewater - MA - United States.
  3. Avery E Gatewood: Bridgewater State University, Department of Biological Sciences - Bridgewater - MA - United States.
  4. Janessa Quintana: Bridgewater State University, Department of Biological Sciences - Bridgewater - MA - United States.
  5. Joseph A Seggio: Bridgewater State University, Department of Biological Sciences - Bridgewater - MA - United States.
PMID: 35082987 DOI: 10.5935/1984-0063.20200096

Abstract

OBJECTIVE: Being visually impaired increases the likelihood of sleep disorders and altered behavior. This study investigated physiological and behavioral differences in two similar mice substrains when exposed to constant light (LL) - CBA/J with retinal degeneration and CBA/CaJ mice (no retinal degeneration).
MATERIAL AND METHODS: Male CBA/J and CBA/CaJ mice were placed into a 12:12 light:dark cycle or constant light (LL). Open field behavior, metabolic markers, and home-cage circadian activity were observed.
RESULTS: CBA/CaJ mice have greater circadian period lengthening, increased weight gain, reduced glucose, and increased novelty-induced locomotor activity in LL, compared to CBA/J mice. LL reduced thyroid hormone and insulin in both substrains.
DISCUSSION: While several baseline substrain differences were elucidated, CBA/CaJ mice were more effected by the exposure to LL than the blind CBA/J mice. These results illustrate that LL causes alterations in physiology and behavior and that circadian photoreceptivity might contribute to these effects.

Keywords

Circadian Rhythm Glucose Tolerance Test Inbred Strains Light Locomotion Mice

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Journal Article
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Word Cloud

Created with Highcharts 10.0.0miceLLCBA/JCBA/CaJbehaviorconstantlightcircadianphysiologicalbehavioraldifferencessubstrainsretinaldegenerationactivityincreasedreducedOBJECTIVE:visuallyimpairedincreaseslikelihoodsleepdisordersalteredstudyinvestigatedtwosimilarexposed-MATERIALANDMETHODS:Maleplaced12:12light:darkcycleOpenfieldmetabolicmarkershome-cageobservedRESULTS:greaterperiodlengtheningweightgainglucosenovelty-inducedlocomotorcomparedthyroidhormoneinsulinDISCUSSION:severalbaselinesubstrainelucidatedeffectedexposureblindresultsillustratecausesalterationsphysiologyphotoreceptivitymightcontributeeffectsStrainspecificresponsesmaleCircadianRhythmGlucoseToleranceTestInbredStrainsLightLocomotionMice

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