Smart Magnetic Nanocarriers for Multi-Stimuli On-Demand Drug Delivery.
Parisa Eslami, Martin Albino, Francesca Scavone, Federica Chiellini, Andrea Morelli, Giovanni Baldi, Laura Cappiello, Saer Doumett, Giada Lorenzi, Costanza Ravagli, Andrea Caneschi, Anna Laurenzana, Claudio Sangregorio
Author Information
Parisa Eslami: INSTM and Dipartimento di Ingegneria Industriale-DIEF, Università degli Studi di Firenze, 50139 Sesto Fiorentino, Italy. ORCID
Martin Albino: INSTM and Dipartimento di Ingegneria Industriale-DIEF, Università degli Studi di Firenze, 50139 Sesto Fiorentino, Italy. ORCID
Francesca Scavone: Dipartimento di Scienze Biomediche Sperimentali e Cliniche Mario Serio, Università degli Studi di Firenze, 50134 Florence, Italy.
Federica Chiellini: INSTM and Dipartimento di Chimica e Chimica Industriale, Università di Pisa, 56124 Pisa, Italy. ORCID
Andrea Morelli: INSTM and Dipartimento di Chimica e Chimica Industriale, Università di Pisa, 56124 Pisa, Italy.
Andrea Caneschi: INSTM and Dipartimento di Ingegneria Industriale-DIEF, Università degli Studi di Firenze, 50139 Sesto Fiorentino, Italy. ORCID
Anna Laurenzana: Dipartimento di Scienze Biomediche Sperimentali e Cliniche Mario Serio, Università degli Studi di Firenze, 50134 Florence, Italy. ORCID
Claudio Sangregorio: INSTM and Dipartimento di Chimica, U. Schiff, Università di Firenze, 50019 Sesto Fiorentino, Italy. ORCID
In this study, we report the realization of drug-loaded smart magnetic nanocarriers constituted by superparamagnetic iron oxide nanoparticles encapsulated in a dual pH- and temperature-responsive poly (N-vinylcaprolactam-co-acrylic acid) copolymer to achieve highly controlled drug release and localized magnetic hyperthermia. The magnetic core was constituted by flower-like magnetite nanoparticles with a size of 16.4 nm prepared by the polyol approach, with good saturation magnetization and a high specific absorption rate. The core was encapsulated in poly (N-vinylcaprolactam-co-acrylic acid) obtaining magnetic nanocarriers that revealed reversible hydration/dehydration transition at the acidic condition and/or at temperatures above physiological body temperature, which can be triggered by magnetic hyperthermia. The efficacy of the system was proved by loading doxorubicin with very high encapsulation efficiency (>96.0%) at neutral pH. The double pH- and temperature-responsive nature of the magnetic nanocarriers facilitated a burst, almost complete release of the drug at acidic pH under hyperthermia conditions, while a negligible amount of doxorubicin was released at physiological body temperature at neutral pH, confirming that in addition to pH variation, drug release can be improved by hyperthermia treatment. These results suggest this multi-stimuli-sensitive nanoplatform is a promising candidate for remote-controlled drug release in combination with magnetic hyperthermia for cancer treatment.
