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Molecules (Basel, Switzerland)
Jan 19, 2022;27 (3):

Glycerol Valorization towards a Benzoxazine Derivative through a Milling and Microwave Sequential Strategy.

Miguel ��ngel Torres-Pastor, Claudia Espro, Maurizio Selva, Alvise Perosa, Antonio A Romero Reyes, Sameh M Osman, Rafael Luque, Daily Rodr��guez-Padr��n
Author Information
  1. Miguel ��ngel Torres-Pastor: Grupo FQM-383, Departamento de Qu��mica Org��nica, Universidad de Cordoba, 14014 Cordoba, Spain.
  2. Claudia Espro: Dipartimento di Ingegneria, Universit�� di Messina, 98100 Messina, Italy. ORCID
  3. Maurizio Selva: Dipartimento di Scienze Molecolari e Nanosistemi, Universit��Ca' Foscari di Venezia, 30123 Venezia, Italy. ORCID
  4. Alvise Perosa: Dipartimento di Scienze Molecolari e Nanosistemi, Universit��Ca' Foscari di Venezia, 30123 Venezia, Italy. ORCID
  5. Antonio A Romero Reyes: Grupo FQM-383, Departamento de Qu��mica Org��nica, Universidad de Cordoba, 14014 Cordoba, Spain. ORCID
  6. Sameh M Osman: Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia. ORCID
  7. Rafael Luque: Grupo FQM-383, Departamento de Qu��mica Org��nica, Universidad de Cordoba, 14014 Cordoba, Spain. ORCID
  8. Daily Rodr��guez-Padr��n: Dipartimento di Ingegneria, Universit�� di Messina, 98100 Messina, Italy. ORCID
PMID: 35163895 DOI: 10.3390/molecules27030632

Abstract

Glycerol and aminophenol intermolecular condensation has been investigated through a milling and microwave-assisted sequential strategy, towards the synthesis of a benzoxaxine derivative. Mechanochemical activation prior to the microwave-assisted process could improve the probability of contact between the reagents, and greatly favors the higher conversion of aminophenol. At the same time, following a mechanochemical-microwave sequential approach could tune the selectivity towards the formation of a benzoxazine derivative, which could find application in a wide range of biomedical areas.

Keywords

benzoxazine derivative glycerol valorization microwave irradiation milling

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Journal Article

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