Invited commentary.

Raphael P H Meier
Author Information
  1. Raphael P H Meier: Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Abstract

No abstract text available.

References

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  2. Meier RPH, Muller YD, Balaphas A, et al. Xenotransplantation: back to the future?. Transpl Int. 2018;31(5):465-477.
  3. New York Times. In a first, man receives a heart from a genetically altered pig. 2022. Accessed January 10, 2022. https://www.nytimes.com/2022/01/10/health/heart-transplant-pig-bennett.html
  4. Porrett PM, Orandi BJ, Kumar V, et al. First clinical-grade porcine kidney xenotransplant using a human decedent model. Am J Transplant. 2022 Jan 20. [Online ahead of print.].
  5. New York Times. In a first, surgeons attached a pig kidney to a human, and it worked. 2021. Accessed October 21, 2021. https://www.nytimes.com/2021/10/19/health/kidney-transplant-pig-human.html. Accessed October 19, 2021.
  6. Ma D, Hirose T, Lassiter G, et al. Kidney transplantation from triple-knockout pigs expressing multiple human proteins in cynomolgus macaques. Am J Transplant. 2022;22(1):46-57.
  7. Mohiuddin MM, Singh AK, Corcoran PC, et al. Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft. Nat Commun. 2016;7:11138.
  8. Mohiuddin M, Kline G, Shen Z, Ruggiero V, Rostami S, Disesa VJ. Experiments in cardiac xenotransplantation - response to intrathymic xenogeneic cells and intravenous cobra venom factor. J Thorac Cardiovasc Surg. 1993;106(4):632-635.
  9. Langin M, Mayr T, Reichart B, et al. Consistent success in life-supporting porcine cardiac xenotransplantation. Nature. 2018;564(7736):430-433.
  10. Shin JS, Min BH, Kim JM, et al. Failure of transplantation tolerance induction by autologous regulatory T cells in the pig-to-non-human primate islet xenotransplantation model. Xenotransplantation. 2016;23(4):300-309.
  11. Kim SC, Mathews DV, Breeden CP, et al. Long-term survival of pig-to-rhesus macaque renal xenografts is dependent on CD4 T cell depletion. Am J Transplant. 2019;19(8):2174-2185.
  12. Byrne GW, Du ZJ, Sun ZF, Asmann YW, McGregor CGA. Changes in cardiac gene expression after pig-to-primate orthotopic xenotransplantation. Xenotransplantation. 2011;18(1):14-27.
  13. Watanabe H, Sahara H, Nomura S, et al. Histologically proven survival of porcine lung xenografts in baboons for up to 10 days using double transgenic hCD47/hCD55 GalT-KO donors. Xenotransplantation. 2017;24(5):30.
  14. Burdorf L, Laird CT, Harris DG, et al. Pig-to-baboon lung xenotransplantation: extended survival with targeted genetic modifications and pharmacologic treatments. Am J Transplant. 2022;22(1):28-45.
  15. Meier RPH, Longchamp A, Mohiuddin M, et al. Recent progress and remaining hurdles toward clinical xenotransplantation. Xenotransplantation. 2021;28(3):e12681.
  16. Adams AB, Lovasik BP, Faber DA, et al. Anti-C5 antibody tesidolumab reduces early antibody-mediated rejection and prolongs survival in renal xenotransplantation. Ann Surg. 2021;274(3):473-480.

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