Immune cell profiles of patients with interstitial cystitis/bladder pain syndrome.
Robert M Moldwin, Vishaan Nursey, Oksana Yaskiv, Siddhartha Dalvi, Eric J Macdonald, Michael Funaro, Chengliang Zhang, William DeGouveia, Marina Ruzimovsky, Horacio R Rilo, Edmund J Miller, Souhel Najjar, Inna Tabansky, Joel N H Stern
Author Information
Robert M Moldwin: The Smith Institute for Urology, Northwell Health, 450 Lakeville Road New Hyde Park, Lake Success, NY, USA.
Vishaan Nursey: Department of Neurology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.
Oksana Yaskiv: Department of Pathology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.
Siddhartha Dalvi: Department of Pathology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.
Eric J Macdonald: The Smith Institute for Urology, Northwell Health, 450 Lakeville Road New Hyde Park, Lake Success, NY, USA.
Michael Funaro: Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Manhasset, NY, USA.
Chengliang Zhang: Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Manhasset, NY, USA.
William DeGouveia: Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Manhasset, NY, USA.
Marina Ruzimovsky: The Smith Institute for Urology, Northwell Health, 450 Lakeville Road New Hyde Park, Lake Success, NY, USA.
Horacio R Rilo: Department of Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.
Edmund J Miller: RDS2 Solutions, Stony Brook, NY, USA.
Souhel Najjar: Department of Neurology, Lenox Hill Hospital, New York, NY, USA.
Inna Tabansky: Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Manhasset, NY, USA.
Joel N H Stern: The Smith Institute for Urology, Northwell Health, 450 Lakeville Road New Hyde Park, Lake Success, NY, USA. joel.n.stern@hofstra.edu. ORCID
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a disorder characterized by bladder pain upon filling which severely affects quality of life. Clinical presentation can vary. Local inflammatory events typify the clinical presentation of IC/BPS patients with Hunner lesions (IC/BPS-HL). It has previously been proposed that B cells are more prevalent in HL, but understanding their exact role in this environment requires a more complete immunological profile of HL. We characterized immunological dysfunction specifically in HL using immunohistochemistry. We detected significantly more plasma cells (50× increase, p < 0.0001), B cells (28× increase, p < 0.0001), T cells (3× increase, p < 0.0001), monocytes/macrophages (6× increase, p < 0.0001), granulocytes (4× increase, p < 0.0001), and natural killer cells (2× increase, p = 0.0249) in IC/BPS patients with HL than in unaffected controls (UC). Patients with IC/BPS-HL also had significantly elevated urinary levels of IL-6 (p = 0.0054), TNF-α (p = 0.0064) and IL-13 (p = 0.0304) compared to patients with IC/BPS without HL (IC/BPS-NHL). In contrast, IL-12p70 levels were significantly lower in the patients with HL than in those without these lesions (p = 0.0422). Different cytokines were elevated in the urine of IC/BPS patients with and without HL, indicating that different disease processes are active in IC/BPS patients with and without HL. Elevated levels of CD138+, CD20+, and CD3+ cells in HL are consistent B and T-cell involvement in disease processes within HL.
References
Cell. 2019 Oct 3;179(2):432-447.e21
[PMID: 31585082]
