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Frontiers in cellular and infection microbiology
2022;12 807253.

Advances in the Rapid Diagnostic of Viral Respiratory Tract Infections.

Gratiela Gradisteanu Pircalabioru, Florina Silvia Iliescu, Grigore Mihaescu, Alina Irina Cucu, Octavian Narcis Ionescu, Melania Popescu, Monica Simion, Liliana Burlibasa, Mihaela Tica, Mariana Carmen Chifiriuc, Ciprian Iliescu
Author Information
  1. Gratiela Gradisteanu Pircalabioru: Research Institute of the University of Bucharest, Bucharest, Romania.
  2. Florina Silvia Iliescu: National Institute for Research and Development in Microtechnologies-IMT, Bucharest, Romania.
  3. Grigore Mihaescu: Faculty of Biology, University of Bucharest, Bucharest, Romania.
  4. Alina Irina Cucu: Faculty of Biology, University of Bucharest, Bucharest, Romania.
  5. Octavian Narcis Ionescu: National Institute for Research and Development in Microtechnologies-IMT, Bucharest, Romania.
  6. Melania Popescu: National Institute for Research and Development in Microtechnologies-IMT, Bucharest, Romania.
  7. Monica Simion: National Institute for Research and Development in Microtechnologies-IMT, Bucharest, Romania.
  8. Liliana Burlibasa: Faculty of Biology, University of Bucharest, Bucharest, Romania.
  9. Mihaela Tica: Emergency University Hospital, Bucharest, Romania.
  10. Mariana Carmen Chifiriuc: Research Institute of the University of Bucharest, Bucharest, Romania.
  11. Ciprian Iliescu: National Institute for Research and Development in Microtechnologies-IMT, Bucharest, Romania.
PMID: 35252028 DOI: 10.3389/fcimb.2022.807253

Abstract

Viral infections are a significant public health problem, primarily due to their high transmission rate, various pathological manifestations, ranging from mild to severe symptoms and subclinical onset. Laboratory diagnostic tests for infectious diseases, with a short enough turnaround time, are promising tools to improve patient care, antiviral therapeutic decisions, and infection prevention. Numerous microbiological molecular and serological diagnostic testing devices have been developed and authorised as benchtop systems, and only a few as rapid miniaturised, fully automated, portable digital platforms. Their successful implementation in virology relies on their performance and impact on patient management. This review describes the current progress and perspectives in developing micro- and nanotechnology-based solutions for rapidly detecting human viral respiratory infectious diseases. It provides a nonexhaustive overview of currently commercially available and under-study diagnostic testing methods and discusses the sampling and viral genetic trends as preanalytical components influencing the results. We describe the clinical performance of tests, focusing on alternatives such as microfluidics-, biosensors-, Internet-of-Things (IoT)-based devices for rapid and accurate viral loads and immunological responses detection. The conclusions highlight the potential impact of the newly developed devices on laboratory diagnostic and clinical outcomes.

Keywords

IoT - internet of things biosensors microfluidics point-of-care viral respiratory infection

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MeSH Term

Biosensing Techniques
Communicable Diseases
Humans
Microfluidics
Respiratory Tract Infections
Serologic Tests
Journal Article Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 4

Word Cloud

Created with Highcharts 10.0.0diagnosticviraldevicesViraltestsinfectiousdiseasespatientinfectiontestingdevelopedrapidperformanceimpactrespiratoryclinicalIoTinfectionssignificantpublichealthproblemprimarilyduehightransmissionratevariouspathologicalmanifestationsrangingmildseveresymptomssubclinicalonsetLaboratoryshortenoughturnaroundtimepromisingtoolsimprovecareantiviraltherapeuticdecisionspreventionNumerousmicrobiologicalmolecularserologicalauthorisedbenchtopsystemsminiaturisedfullyautomatedportabledigitalplatformssuccessfulimplementationvirologyreliesmanagementreviewdescribescurrentprogressperspectivesdevelopingmicro-nanotechnology-basedsolutionsrapidlydetectinghumanprovidesnonexhaustiveoverviewcurrentlycommerciallyavailableunder-studymethodsdiscussessamplinggenetictrendspreanalyticalcomponentsinfluencingresultsdescribefocusingalternativesmicrofluidics-biosensors-Internet-of-Things-basedaccurateloadsimmunologicalresponsesdetectionconclusionshighlightpotentialnewlylaboratoryoutcomesAdvancesRapidDiagnosticRespiratoryTractInfections-internetthingsbiosensorsmicrofluidicspoint-of-care

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