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Advanced materials (Deerfield Beach, Fla.)
Jul, 2022;34 (30): e2201085.

Emerging Biosensing Technologies for the Diagnostics of Viral Infectious Diseases.

Gözde Kabay, Jonalyn DeCastro, Alara Altay, Kasey Smith, Hsiang-Wei Lu, Antonia McDonnell Capossela, Maryam Moarefian, Kiana Aran, Can Dincer
Author Information
  1. Gözde Kabay: FIT Freiburg Center for Interactive Materials and Bioinspired Technologies, University of Freiburg, 79110, Freiburg, Germany.
  2. Jonalyn DeCastro: The Claremont Colleges, Keck Graduate Institute, Claremont, CA, 91711, USA.
  3. Alara Altay: FIT Freiburg Center for Interactive Materials and Bioinspired Technologies, University of Freiburg, 79110, Freiburg, Germany.
  4. Kasey Smith: The Claremont Colleges, Keck Graduate Institute, Claremont, CA, 91711, USA.
  5. Hsiang-Wei Lu: The Claremont Colleges, Keck Graduate Institute, Claremont, CA, 91711, USA.
  6. Antonia McDonnell Capossela: The Claremont Colleges, Keck Graduate Institute, Claremont, CA, 91711, USA.
  7. Maryam Moarefian: The Claremont Colleges, Keck Graduate Institute, Claremont, CA, 91711, USA.
  8. Kiana Aran: The Claremont Colleges, Keck Graduate Institute, Claremont, CA, 91711, USA.
  9. Can Dincer: FIT Freiburg Center for Interactive Materials and Bioinspired Technologies, University of Freiburg, 79110, Freiburg, Germany. ORCID
PMID: 35288985 DOI: 10.1002/adma.202201085

Abstract

Several viral infectious diseases appear limitless since the beginning of the 21 century, expanding into pandemic lengths. Thus, there are extensive efforts to provide more efficient means of diagnosis, a better understanding of acquired immunity, and improved monitoring of inflammatory biomarkers, as these are all crucial for controlling the spread of infection while aiding in vaccine development and improving patient outcomes. In this regard, various biosensors have been developed recently to streamline pathogen and immune response detection by addressing the limitations of traditional methods, including isothermal amplification-based systems and lateral flow assays. This review explores state-of-the-art biosensors for detecting viral pathogens, serological assays, and inflammatory biomarkers from the material perspective, by discussing their advantages, limitations, and further potential regarding their analytical performance, clinical utility, and point-of-care adaptability. Additionally, next-generation biosensing technologies that offer better sensitivity and selectivity, and easy handling for end-users are highlighted. An emerging example of these next-generation biosensors are those powered by novel synthetic biology tools, such as clustered regularly interspaced short palindromic repeats (CRISPR) with CRISPR-associated proteins (Cas), in combination with integrated point-of-care devices. Lastly, the current challenges are discussed and a roadmap for furthering these advanced biosensing technologies to manage future pandemics is provided.

Keywords

CRISPR/Cas technology biosensors host immune response point-of-care testing viruses

References

  1. K. Shinya, M. Ebina, S. Yamada, M. Ono, N. Kasai, Y. Kawaoka, Nature 2006, 440, 435.
  2. D. Baud, D. J. Gubler, B. Schaub, M. C. Lanteri, D. Musso, Lancet 2017, 390, 2099.
  3. K. Dhama, S. Khan, R. Tiwari, S. Sircar, S. Bhat, Y. S. Malik, K. P. Singh, W. Chaicumpa, D. K. Bonilla-Aldana, A. J. Rodriguez-Morales, Clin. Microbiol. Rev. 2020, 33, e00028.
  4. H. Feldmann, S. Jones, H.-D. Klenk, H.-J. Schnittler, Nat. Rev. Immunol. 2003, 3, 677.
  5. B. Rehermann, M. Nascimbeni, Nat. Rev. Immunol. 2005, 5, 215.
  6. P. Zhou, X.-L. Yang, X.-G. Wang, B. Hu, L. Zhang, W. Zhang, H.-R. Si, Y. Zhu, B. Li, C.-L. Huang, H.-D. Chen, J. Chen, Y. Luo, H. Guo, R.-D. Jiang, M.-Q. Liu, Y. Chen, X.-R. Shen, X. Wang, X.-S. Zheng, K. Zhao, Q.-J. Chen, F. Deng, L.-L. Liu, B. Yan, F.-X. Zhan, Y.-Y. Wang, G.-F. Xiao, Z.-L. Shi, Nature 2020, 579, 270.
  7. C. Drosten, S. Günther, W. Preiser, S. van der Werf, H.-R. Brodt, S. Becker, H. Rabenau, M. Panning, L. Kolesnikova, R. A. M. Fouchier, A. Berger, A.-M. Burguière, J. Cinatl, M. Eickmann, N. Escriou, K. Grywna, S. Kramme, J.-C. Manuguerra, S. Müller, V. Rickerts, M. Stürmer, S. Vieth, H.-D. Klenk, A. D. M. E. Osterhaus, H. Schmitz, H. W. Doerr, N. Engl. J. Med. 2003, 348, 1967.
  8. A. M. Zaki, S. van Boheemen, T. M. Bestebroer, A. D. M. E. Osterhaus, R. A. M. Fouchier, N. Engl. J. Med. 2012, 367, 1814.
  9. World Health Organization, “WHO Coronavirus (COVID-19) Dashboard,” can be found under https://covid19.who.int, 2020.
  10. B. D. Kevadiya, J. Machhi, J. Herskovitz, M. D. Oleynikov, W. R. Blomberg, N. Bajwa, D. Soni, S. Das, M. Hasan, M. Patel, A. M. Senan, S. Gorantla, J. McMillan, B. Edagwa, R. Eisenberg, C. B. Gurumurthy, S. P. M. Reid, C. Punyadeera, L. Chang, H. E. Gendelman, Nat. Mater. 2021, 20, 593.
  11. N. Castaño, S. C. Cordts, M. Kurosu Jalil, K. S. Zhang, S. Koppaka, A. D. Bick, R. Paul, S. K. Y. Tang, ACS Omega 2021, 6, 6509.
  12. R. Subramanian, Q. He, M. Pascual, Proc. Natl. Acad. Sci. USA 2021, 118, e2019716118.
  13. S. Mavrikou, G. Moschopoulou, V. Tsekouras, S. Kintzios, Sensors 2020, 20, 3121.
  14. C. Dincer, R. Bruch, E. Costa-Rama, M. T. Fernández-Abedul, A. Merkoçi, A. Manz, G. A. Urban, F. Güder, Adv. Mater. 2019, 31, 1806739.
  15. P. J. Rosenthal, Am. J. Trop. Med. Hyg. 2020, 102, 915.
  16. Z. Shen, Y. Xiao, L. Kang, W. Ma, L. Shi, L. Zhang, Z. Zhou, J. Yang, J. Zhong, D. Yang, L. Guo, G. Zhang, H. Li, Y. Xu, M. Chen, Z. Gao, J. Wang, L. Ren, M. Li, Clin. Infect. Dis. 2020, 71, 713.
  17. M. Valassina, A. M. Cuppone, M. G. Cusi, P. E. Valensin, Clin. Diagn. Virol. 1997, 8, 227.
  18. A. Tahamtan, A. Ardebili, Expert Rev. Mol. Diagn. 2020, 20, 453.
  19. J. D. Robin, A. T. Ludlow, R. LaRanger, W. E. Wright, J. W. Shay, Sci. Rep. 2016, 6, 24067.
  20. G. M. Ke, H. L. Cheng, L. Y. Ke, W. T. Ji, J. L. C. Chulu, M. H. Liao, T. J. Chang, H. J. Liu, J. Virol. Methods 2006, 133, 6.
  21. J. D. Diaz-Decaro, N. M. Green, H. A. Godwin, Expert Rev. Mol. Diagn. 2018, 18, 631.
  22. R. Weissleder, H. Lee, J. Ko, M. J. Pittet, Sci. Transl. Med. 2020, 12, eabc1931.
  23. J. B. Nuzzo, Health Secur. 2017, 15, 17.
  24. W. Zhang, B. D. Davis, S. S. Chen, J. M. Sincuir Martinez, J. T. Plummer, E. Vail, J. Am. Med. Assoc. 2021, 325, 1324.
  25. Z. Li, Y. Yi, X. Luo, N. Xiong, Y. Liu, S. Li, R. Sun, Y. Wang, B. Hu, W. Chen, Y. Zhang, J. Wang, B. Huang, Y. Lin, J. Yang, W. Cai, X. Wang, J. Cheng, Z. Chen, K. Sun, W. Pan, Z. Zhan, L. Chen, F. Ye, J. Med. Virol. 2020, 92, 1518.
  26. D. Sterlin, A. Mathian, M. Miyara, A. Mohr, F. Anna, L. Claër, P. Quentric, J. Fadlallah, H. Devilliers, P. Ghillani, C. Gunn, R. Hockett, S. Mudumba, A. Guihot, C.-E. Luyt, J. Mayaux, A. Beurton, S. Fourati, T. Bruel, O. Schwartz, J.-M. Lacorte, H. Yssel, C. Parizot, K. Dorgham, P. Charneau, Z. Amoura, G. Gorochov, Sci. Transl. Med. 2021, 13, eabd2223.
  27. Y. Galipeau, M. Greig, G. Liu, M. Driedger, M.-A. Langlois, Front. Immunol. 2020, 11, 610688.
  28. L. Cinquanta, D. E. Fontana, N. Bizzaro, Autoimmun. Highlights 2017, 8, 9.
  29. M. F. Clark, R. M. Lister, M. Bar-Joseph, ELISA techniques, Methods Enzymol. 1986, 118, 742
  30. K. M. Koczula, A. Gallotta, Essays Biochem. 2016, 60, 111.
  31. J. D. Whitman, J. Hiatt, C. T. Mowery, B. R. Shy, R. Yu, T. N. Yamamoto, U. Rathore, G. M. Goldgof, C. Whitty, J. M. Woo, A. E. Gallman, T. E. Miller, A. G. Levine, D. N. Nguyen, S. P. Bapat, J. Balcerek, S. A. Bylsma, A. M. Lyons, S. Li, A. W. Wong, E. M. Gillis-Buck, Z. B. Steinhart, Y. Lee, R. Apathy, M. J. Lipke, J. A. Smith, T. Zheng, I. C. Boothby, E. Isaza, J. Chan, et al., Nat. Biotechnol. 2020, 38, 1174.
  32. C. for D. and R. Health, “Coronavirus Disease 2019 (COVID-19) Emergency Use Authorizations for Medical Devices,” can be found under https://www.fda.gov/medical-devices/emergency-use-authorizations-medical-devices/coronavirus-disease-2019-covid-19-emergency-use-authorizations-medical-devices, 2021.
  33. M. J. Mina, R. Parker, D. B. Larremore, N. Engl. J. Med. 2020, 383, e120.
  34. T. Ji, Z. Liu, G. Wang, X. Guo, S. Akbar khan, C. Lai, H. Chen, S. Huang, S. Xia, B. Chen, H. Jia, Y. Chen, Q. Zhou, Biosens. Bioelectron. 2020, 166, 112455.
  35. N. Bhalla, P. Jolly, N. Formisano, P. Estrela, Essays Biochem. 2016, 60, 1.
  36. D. O'Hare, in Biosensors and Sensor Systems. Body Sensor Networks (Ed: G.-Z. Yang), Springer, 2nd Ed., London, 2014, pp. 55-115.
  37. B. N. Johnson, R. Mutharasan, Analyst 2014, 139, 1576.
  38. M. Ritzi-Lehnert, Expert Rev. Mol. Diagn. 2012, 12, 189.
  39. X. Hou, Y. S. Zhang, G. T. Santiago, M. M. Alvarez, J. Ribas, S. J. Jonas, P. S. Weiss, A. M. Andrews, J. Aizenberg, A. Khademhosseini, Nat. Rev. Mater. 2017, 2, 17016.
  40. H. A. Alhadrami, Biotechnol. Appl. Biochem. 2018, 65, 497.
  41. B. Purohit, P. R. Vernekar, N. P. Shetti, P. Chandra, Sens. Int. 2020, 1, 100040.
  42. S. M. Yoo, S. Y. Lee, Trends Biotechnol. 2016, 34, 7.
  43. H. Nguyen, J. Park, S. Kang, M. Kim, Sensors 2015, 15, 10481.
  44. N. S. Ferreira, M. G. F. Sales, Biosens. Bioelectron. 2014, 53, 193.
  45. P. Leonard, S. Hearty, J. Brennan, L. Dunne, J. Quinn, T. Chakraborty, R. O'Kennedy, Enzyme Microb. Technol. 2003, 32, 3.
  46. G. Papadakis, P. Murasova, A. Hamiot, K. Tsougeni, G. Kaprou, M. Eck, D. Rabus, Z. Bilkova, B. Dupuy, G. Jobst, A. Tserepi, E. Gogolides, E. Gizeli, Biosens. Bioelectron. 2018, 111, 52.
  47. M. Megens, M. Prins, J. Magn. Magn. Mater. 2005, 293, 702.
  48. K. Ramanathan, B. Danielsson, Biosens. Bioelectron. 2001, 16, 417.
  49. A. Hlaváček, M. J. Mickert, T. Soukka, S. Lahtinen, T. Tallgren, N. Pizúrová, A. Król, H. H. Gorris, Anal. Chem. 2019, 91, 1241.
  50. H. Malekzad, P. Sahandi Zangabad, H. Mirshekari, M. Karimi, M. R. Hamblin, Nanotechnol. Rev. 2017, 6, 301.
  51. M. Holzinger, A. Le Goff, S. Cosnier, Front. Chem. 2014, 2.
  52. E. Heydari-Bafrooei, A. A. Ensafi, in Electrochemical Biosensors,(Ed: A. A. Ensafi), Elsevier, Amsterdam 2019, pp. 77-98, https://doi.org/10.1016/B978-0-12-816491-4.00004-8.
  53. N. Sandhyarani, in. Electrochemical Biosensors, (Ed: A. A. Ensafi), Elsevier, Amsterdam 2019, pp. 45-75, https://doi.org/10.1016/B978-0-12-816491-4.00003-6.
  54. J. Lei, H. Ju, Chem. Soc. Rev. 2012, 41, 2122.
  55. A. Rasooly, B. Prickril, Biosensors and Biodetection: Methods and Protocols Volume 1: Optical-Based Detectors, Humana Press, New York, Methods in Molecular Biology, 1st Ed., 2009, 501, 472.
  56. V. Perumal, U. Hashim, Advances in biosensors: Principle, architecture and applications, J. Appl. Biomed. 2014, 12, 1
  57. M. Zourob, Recognition Receptors in Biosensors, Springer, New York 2010.
  58. O. Hayden, P. A. Lieberzeit, D. Blaas, F. L. Dickert, Artificial antibodies for bioanalyte detection-Sensing viruses and proteins, Adv. Funct. Mater. 2006, 16, 1269
  59. M. A. Morales, J. M. Halpern, Bioconjugate Chem. 2018, 29, 3231.
  60. F. M. Marty, K. Chen, K. A. Verrill, N. Engl. J. Med. 2020, 382, e76.
  61. A. A. Zasada, K. Zacharczuk, K. Woźnica, M. Główka, R. Ziółkowski, E. Malinowska, AMB Express 2020, 10, 46.
  62. N. Bunyakul, A. Baeumner, Sensors 2014, 15, 547.
  63. K. D. Clark, C. Zhang, J. L. Anderson, Anal. Chem. 2016, 88, 11262.
  64. Spindiag, “Rhonda SARS COV-2 disk,” can be found under https://www.spindiag.de/sars-cov-2-disk/, 2021.
  65. A. Ferrand, K. D. Schleicher, N. Ehrenfeuchter, W. Heusermann, O. Biehlmaier, Sci. Rep. 2019, 9, 1165.
  66. M. Shokrekhodaei, S. Quinones, Z. Fazel, H. Nazeran, Adv. Electr. Electron. Eng. 2019, 17, 64.
  67. Y.-D. Ma, K.-H. Li, Y.-H. Chen, Y.-M. Lee, S.-T. Chou, Y.-Y. Lai, P.-C. Huang, H.-P. Ma, G.-B. Lee, Lab Chip 2019, 19, 3804.
  68. A. Priye, C. S. Ball, R. J. Meagher, Anal. Chem. 2018, 90, 12385.
  69. S. Jain, M. Nehra, R. Kumar, N. Dilbaghi, T. Hu, S. Kumar, A. Kaushik, C. Li, Biosens. Bioelectron. 2021, 179, 113074.
  70. M. Mayer, A. J. Baeumner, Chem. Rev. 2019, 119, 7996.
  71. A. Altay, R. Learney, F. Güder, C. Dincer, Trends Biotechnol. 2022, 40, 141.
  72. J. C. Huang, Y.-F. Chang, K.-H. Chen, L.-C. Su, C.-W. Lee, C.-C. Chen, Y.-M. A. Chen, C. Chou, Biosens. Bioelectron. 2009, 25, 320.
  73. X. Che, L. Qiu, Y. Pan, K. Wen, W. Hao, L. Zhang, Y. Wang, Z. Liao, X. Hua, V. C. C. Cheng, K. Yuen, J. Clin. Microbiol. 2004, 42, 2629.
  74. B. Yang, H. Gong, C. Chen, X. Chen, C. Cai, Biosens. Bioelectron. 2017, 87, 679.
  75. B. Zuo, S. Li, Z. Guo, J. Zhang, C. Chen, Anal. Chem. 2004, 76, 3536.
  76. F. Patolsky, G. Zheng, O. Hayden, M. Lakadamyali, X. Zhuang, C. M. Lieber, Proc. Natl. Acad. Sci. USA 2004, 101, 14017.
  77. V. D. Krishna, K. Wu, A. M. Perez, J.-P. Wang, Front. Microbiol. 2016, 7, 1.
  78. R. Vainionpää, P. Leinikki, in Encyclopedia of Virology, (Eds: B. W. J. Mahy, M. H. V. Van Regenmortel), 3, Elsevier, Amsterdam 2008, pp. 29-37, https://doi.org/10.1016/B978-012374410-4.00585-9.
  79. A. Sinha, R. Lutter, T. Dekker, B. Dierdorp, P. J. Sterk, U. Frey, E. Delgado-Eckert, Viruses 2020, 12, 1175.
  80. B. O'Farrell, in Evolution in Lateral Flow-Based Immunoassay Systems. (Eds: R. Wong, H. Tse), Lateral Flow Immunoassay, Humana Press, Totowa, NJ 2009, pp. 1-33, https://doi.org/10.1007/978-1-59745-240-3_1.
  81. T. Peto, D. Affron, B. Afrough, A. Agasu, M. Ainsworth, A. Allanson, K. Allen, C. Allen, L. Archer, N. Ashbridge, I. Aurfan, M. Avery, E. Badenoch, P. Bagga, R. Balaji, E. Baldwin, S. Barraclough, C. Beane, J. Bell, T. Benford, S. Bird, M. Bishop, A. Bloss, R. Body, R. Boulton, A. Bown, C. Bratten, C. Bridgeman, D. Britton, T. Brooks, et al., EClinicalMedicine 2021, 36, 100924.
  82. Y. Pan, L. Long, D. Zhang, T. Yuan, S. Cui, P. Yang, Q. Wang, S. Ren, Clin. Chem. 2020, 66, 794.
  83. J. Ziebuhr, Curr. Top. Microbiol. Immunol. 2005, 287, 57.
  84. P. S. Masters, Virology 2019, 537, 198.
  85. G. Seo, G. Lee, M. J. Kim, S.-H. Baek, M. Choi, K. B. Ku, C.-S. Lee, S. Jun, D. Park, H. G. Kim, S. I. S.-J. Kim, J.-O. Lee, B. T. Kim, E. C. Park, S. I. S.-J. Kim, ACS Nano 2020, 14, 5135.
  86. Y. Sun, Y. Bai, D. Song, X. Li, L. Wang, H. Zhang, Biosens. Bioelectron. 2007, 23, 473.
  87. E. Kretschmann, H. Raether, Z. Naturforsch. A 1968, 23, 2135.
  88. A. A. Yanik, M. Huang, O. Kamohara, A. Artar, T. W. Geisbert, J. H. Connor, H. Altug, Nano Lett. 2010, 10, 4962.
  89. T. J. Park, M. S. Hyun, H. J. Lee, S. Y. Lee, S. Ko, Talanta 2009, 79, 295.
  90. R. C. Stringer, S. Schommer, D. Hoehn, S. A. Grant, Sens. Actuators, B 2008, 134, 427
  91. L. Mockus, J. J. Peterson, J. M. Lainez, G. V. Reklaitis, Org. Process Res. Dev. 2015, 19, 908
  92. J. Nette, P. D. Howes, A. J. DeMello, Adv. Mater. Technol. 2020, 5, 2000060.
  93. A. J. DeMello, Nature 2006, 442, 394.
  94. A. Stambaugh, J. W. Parks, M. A. Stott, G. G. Meena, A. R. Hawkins, H. Schmidt, Proc. Natl. Acad. Sci. USA 2021, 118, 2.
  95. X. Yang, C. Gong, Y. Liu, Y. Rao, M. Smietana, Y. Gong, Photonic Sens. 2021, 11, 262
  96. L. He, S. K. Ozdemir, J. Zhu, W. Kim, L. Yang, Nat. Nanotechnol. 2011, 6, 428.
  97. Y. Liu, X. Zhang, Micromachines 2021, 12, 826.
  98. Y. Zhang, Y. Zhao, T. Zhou, Q. Wu, Lab Chip 2018, 18, 57
  99. J. E. Baker, R. Sriram, B. L. Miller, Lab Chip 2017, 17, 1570.
  100. Z. Fu, Y.-C. Lu, J. J. Lai, Chonnam Med. J. 2019, 55, 86.
  101. S. Esposito, A. Mencacci, E. Cenci, B. Camilloni, E. Silvestri, N. Principi, Front. Cell. Infect. Microbiol. 2019, 9.
  102. J. Li, J. Macdonald, Biosens. Bioelectron. 2016, 83, 177.
  103. National Center for Immunization and Respiratory Diseases (NCIRD), Division of Viral Diseases, “CDC's Influenza SARS-CoV-2 Multiplex Assay and Required Supplies,” can be found under https://www.cdc.gov/coronavirus/2019-ncov/lab/multiplex.html, 2020.
  104. R. D. Blevins, R. Plunkett, J. Appl. Mech. 1980, 47, 461.
  105. D. Ozcelik, J. W. J. W. Parks, T. A. Wall, M. A. Stott, H. Cai, J. W. J. W. Parks, A. R. Hawkins, H. Schmidt, Proc. Natl. Acad. Sci. USA 2015, 112, 12933.
  106. Y. Shi, K. T. Nguyen, L. K. Chin, Z. Li, L. Xiao, H. Cai, R. Yu, W. Huang, S. Feng, P. H. Yap, J. Liu, Y. Zhang, A. Q. Liu, ACS Sens. 2021, 6, 3445.
  107. R. M. Torrente-Rodríguez, H. Lukas, J. Tu, J. Min, Y. Yang, C. Xu, H. B. Rossiter, W. Gao, Matter 2020, 3, 1981
  108. M. D. T. Torres, W. R. de Araujo, L. F. de Lima, A. L. Ferreira, C. de la Fuente-Nunez, Matter 2021, 4, 2403
  109. L. Chen, X. Wang, W. Lu, X. Wu, J. Li, Chem. Soc. Rev. 2016, 45, 2137.
  110. S. Matsunaga, S. S. Jeremiah, K. Miyakawa, D. Kurotaki, S. Shizukuishi, K. Watashi, H. Nishitsuji, H. Kimura, T. Tamura, N. Yamamoto, K. Shimotohno, T. Wakita, A. Ryo, iScience 2020, 23, 100867.
  111. F. N. Ishikawa, H.-K. Chang, M. Curreli, H.-I. Liao, C. A. Olson, P.-C. Chen, R. Zhang, R. W. Roberts, R. Sun, R. J. Cote, M. E. Thompson, C. Zhou, ACS Nano 2009, 3, 1219.
  112. M. Jenik, R. Schirhagl, C. Schirk, O. Hayden, P. Lieberzeit, D. Blaas, G. Paul, F. L. Dickert, Anal. Chem. 2009, 81, 5320.
  113. World Health Organization, “Tracking SARS-CoV-2 variants,” can be found under https://www.who.int/health-topics/typhoid/tracking-SARS-CoV-2-variants, 2021.
  114. K. Guo, S. Wustoni, A. Koklu, E. Díaz-Galicia, M. Moser, A. Hama, A. A. Alqahtani, A. N. Ahmad, F. S. Alhamlan, M. Shuaib, A. Pain, I. McCulloch, S. T. Arold, R. Grünberg, S. Inal, Nat. Biomed. Eng. 2021, 5, 666.
  115. A. D. Ellington, J. W. Szostak, Nature 1990, 346, 818.
  116. C. H. van den Kieboom, S. L. van der Beek, T. Mészáros, R. E. Gyurcsányi, G. Ferwerda, M. I. de Jonge, TrAC, Trends Anal. Chem. 2015, 74, 58.
  117. J. Labuda, A. M. O. Brett, G. Evtugyn, M. Fojta, M. Mascini, M. Ozsoz, I. Palchetti, E. Paleček, J. Wang, Pure Appl. Chem. 2010, 82, 1161
  118. C. Bai, Z. Lu, H. Jiang, Z. Yang, X. Liu, H. Ding, H. Li, J. Dong, A. Huang, T. Fang, Y. Jiang, L. Zhu, X. Lou, S. Li, N. Shao, Biosens. Bioelectron. 2018, 110, 162.
  119. J. Bhardwaj, N. Chaudhary, H. Kim, J. Jang, Anal. Chim. Acta 2019, 1064, 94.
  120. H.-C. Lai, C.-H. Wang, T.-M. Liou, G.-B. Lee, Lab Chip 2014, 14, 2002.
  121. D. K. W. Chu, Y. Pan, S. M. S. Cheng, K. P. Y. Hui, P. Krishnan, Y. Liu, D. Y. M. Ng, C. K. C. Wan, P. Yang, Q. Wang, M. Peiris, L. L. M. Poon, Clin. Chem. 2020, 66, 549.
  122. D. N. Fredricks, D. A. Relman, Clin. Infect. Dis. 1999, 29, 475.
  123. G. Heilek, in Nucleic Acids - From Basic Aspects to Laboratory Tools (Eds: M. L. Larramendy, S. Soloneski), InTech, London 2016.
  124. M. G. Ghannam, M. Varacallo, Biochemistry, Polymerase Chain Reaction. [Updated 2021 May 9]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022. Available from: https://www.ncbi.nlm.nih.gov/books/NBK535453/
  125. L. Garibyan, N. Avashia, J. Invest. Dermatol. 2013, 133, 1.
  126. E. Nunez-Bajo, A. Silva Pinto Collins, M. Kasimatis, Y. Cotur, T. Asfour, U. Tanriverdi, M. Grell, M. Kaisti, G. Senesi, K. Stevenson, F. Güder, Nat. Commun. 2020, 11, 6176.
  127. J. P. Broughton, X. Deng, G. Yu, C. L. Fasching, V. Servellita, J. Singh, X. Miao, J. A. Streithorst, A. Granados, A. Sotomayor-Gonzalez, K. Zorn, A. Gopez, E. Hsu, W. Gu, S. Miller, C. Y. Pan, H. Guevara, D. A. Wadford, J. S. Chen, C. Y. Chiu, Nat. Biotechnol. 2020, 38, 870.
  128. J. F.-W. Chan, C. C.-Y. Yip, K. K.-W. To, T. H.-C. Tang, S. C.-Y. Wong, K.-H. Leung, A. Y.-F. Fung, A. C.-K. Ng, Z. Zou, H.-W. Tsoi, G. K.-Y. Choi, A. R. Tam, V. C.-C. Cheng, K.-H. Chan, O. T.-Y. Tsang, K.-Y. Yuen, J. Clin. Microbiol. 2020, 58, e00310.
  129. E. Morales-Narváez, C. Dincer, Biosens. Bioelectron. 2020, 163, 112274.
  130. T. Chaibun, J. Puenpa, T. Ngamdee, N. Boonapatcharoen, P. Athamanolap, A. P. O'Mullane, S. Vongpunsawad, Y. Poovorawan, S. Y. Lee, B. Lertanantawong, Nat. Commun. 2021, 12, 802.
  131. P. Teengam, W. Siangproh, A. Tuantranont, T. Vilaivan, O. Chailapakul, C. S. Henry, Anal. Chem. 2017, 89, 5428.
  132. P. Fozouni, S. Son, M. Díaz de León Derby, G. J. Knott, C. N. Gray, M. V. D'Ambrosio, C. Zhao, N. A. Switz, G. R. Kumar, S. I. Stephens, D. Boehm, C.-L. Tsou, J. Shu, A. Bhuiya, M. Armstrong, A. R. Harris, P.-Y. Chen, J. M. Osterloh, A. Meyer-Franke, B. Joehnk, K. Walcott, A. Sil, C. Langelier, K. S. Pollard, E. D. Crawford, A. S. Puschnik, M. Phelps, A. Kistler, J. L. DeRisi, J. A. Doudna, et al., Cell 2020, 184, 323
  133. L. Zanoli, G. Spoto, Biosensors 2012, 3, 18.
  134. H. Kuhn, V. V. Demidov, M. D. Frank-Kamenetskii, Nucleic Acids Res. 2002, 30, 574.
  135. T. Notomi, T. Notomi, T. Okayama, H. Masubuchi, H. Yonekawa, T. Watanabe, K. Amino, N. Hase, Nucleic Acids Res. 2000, 28, 63e.
  136. X. Zhu, X. Wang, L. Han, T. Chen, L. Wang, H. Li, S. Li, L. He, X. Fu, S. Chen, M. Xing, H. Chen, Y. Wang, Biosens. Bioelectron. 2020, 166, 112437.
  137. I. M. Lobato, C. K. O'Sullivan, TrAC, Trends Anal. Chem. 2018, 98, 19.
  138. O. Behrmann, I. Bachmann, M. Spiegel, M. Schramm, A. Abd El Wahed, G. Dobler, G. Dame, F. T. Hufert, Clin. Chem. 2020, 66, 1047.
  139. B. Koo, C. E. Jin, T. Y. Lee, J. H. Lee, M. K. Park, H. Sung, S. Y. Park, H. J. Lee, S. M. Kim, J. Y. Kim, S.-H. Kim, Y. Shin, Biosens. Bioelectron. 2017, 90, 187.
  140. H. E. Kim, A. Schuck, S. H. Lee, Y. Lee, M. Kang, Y.-S. Kim, Biosens. Bioelectron. 2021, 182, 113168.
  141. R. J. Meagher, A. Priye, Y. K. Light, C. Huang, E. Wang, Analyst 2018, 143, 1924.
  142. J. C. Rolando, E. Jue, J. T. Barlow, R. F. Ismagilov, Nucleic Acids Res. 2020, 48, e42.
  143. I. Smyrlaki, M. Ekman, A. Lentini, N. Rufino de Sousa, N. Papanicolaou, M. Vondracek, J. Aarum, H. Safari, S. Muradrasoli, A. G. Rothfuchs, J. Albert, B. Högberg, B. Reinius, Nat. Commun. 2020, 11, 4812.
  144. H. Kutluk, R. Bruch, G. A. Urban, C. Dincer, Biosens. Bioelectron. 2020, 148, 111824.
  145. L. Shi, Q. Sun, J. He, H. Xu, C. Liu, C. Zhao, Y. Xu, C. Wu, J. Xiang, D. Gu, J. Long, H. Lan, Biomed. Mater. Eng. 2015, 26, S2207.
  146. G. Martínez-Paredes, M. B. González-García, A. Costa-García, Electroanalysis 2009, 21, 379.
  147. National Center for Immunization and Respiratory Diseases (NCIRD), Division of Viral Diseases, “SARS-CoV-2 Variant Classifications and Definitions,” can be found under https://www.cdc.gov/coronavirus/2019-ncov/variants/variant-classifications.html, 2020.
  148. W.-S. Choi, J. H. Jeong, H. D. G. Nicolas, S. Oh, K. J. C. Antigua, J.-H. Park, B. Kim, S.-W. Yoon, K. S. Shin, Y. K. Choi, Y. H. Baek, M.-S. Song, Diagnostics 2020, 10, 775.
  149. K. Du, H. Cai, M. Park, T. A. Wall, M. A. Stott, K. J. Alfson, A. Griffiths, R. Carrion, J. L. Patterson, A. R. Hawkins, H. Schmidt, R. A. Mathies, Biosens. Bioelectron. 2017, 91, 489.
  150. H. Cai, J. W. Parks, T. A. Wall, M. A. Stott, A. Stambaugh, K. Alfson, A. Griffiths, R. A. Mathies, R. Carrion, J. L. Patterson, A. R. Hawkins, H. Schmidt, Sci. Rep. 2015, 5, 14494.
  151. M. Makela, P. T. Lin, Anal. Chem. 2021, 93, 4154.
  152. J. D. Sander, J. K. Joung, Nat. Biotechnol. 2014, 32, 347.
  153. P. Mali, L. Yang, K. M. Esvelt, J. Aach, M. Guell, J. E. DiCarlo, J. E. Norville, G. M. Church, Science 2013, 339, 823.
  154. E. Senís, C. Fatouros, S. Große, E. Wiedtke, D. Niopek, A.-K. Mueller, K. Börner, D. Grimm, Biotechnol. J. 2014, 9, 1402.
  155. B. Chen, L. A. Gilbert, B. A. Cimini, J. Schnitzbauer, W. Zhang, G.-W. Li, J. Park, E. H. Blackburn, J. S. Weissman, L. S. Qi, B. Huang, Cell 2013, 155, 1479.
  156. H. Shinoda, Y. Taguchi, R. Nakagawa, A. Makino, S. Okazaki, M. Nakano, Y. Muramoto, C. Takahashi, I. Takahashi, J. Ando, T. Noda, O. Nureki, H. Nishimasu, R. Watanabe, Commun. Biol. 2021, 4, 476.
  157. A. Srivastava, S. Srivastava, D. J. Upadhyay, Front. Mol. Biosci. 2020, 7, 582499.
  158. F. Zhao, E. Y. Lee, G. S. Noh, J. Shin, H. Liu, Z. Qiao, Y. Shin, Sci. Rep. 2019, 9, 16374.
  159. R. Aman, A. Mahas, M. Mahfouz, ACS Synth. Biol. 2020, 9, 1226.
  160. M. Mehravar, A. Shirazi, M. M. Mehrazar, M. Nazari, M. Mehravar, M. Shirazi, A. Mehrazar, M. M. Nazari, Avicenna J. Med. Biotechnol. 2019, 11, 259.
  161. K. Pardee, A. A. Green, M. K. Takahashi, D. Braff, G. Lambert, J. W. Lee, T. Ferrante, D. Ma, N. Donghia, M. Fan, N. M. Daringer, I. Bosch, D. M. Dudley, D. H. O'Connor, L. Gehrke, J. J. Collins, Cell 2016, 165, 1255.
  162. L. Zhou, R. Peng, R. Zhang, J. Li, J. Cell. Mol. Med. 2018, 22, 5807.
  163. J.-H. Tsou, Q. Leng, F. Jiang, Transl. Oncol. 2019, 12, 1566.
  164. M. R. O'Connell, J. Mol. Biol. 2019, 431, 66.
  165. J. S. Gootenberg, O. O. Abudayyeh, J. W. Lee, P. Essletzbichler, A. J. Dy, J. Joung, V. Verdine, N. Donghia, N. M. Daringer, C. A. Freije, C. Myhrvold, R. P. Bhattacharyya, J. Livny, A. Regev, E. V. Koonin, D. T. Hung, P. C. Sabeti, J. J. Collins, F. Zhang, Science 2017, 356, 438.
  166. J. E. van Dongen, J. T. W. Berendsen, R. D. M. Steenbergen, R. M. F. Wolthuis, J. C. T. Eijkel, L. I. Segerink, Biosens. Bioelectron. 2020, 166, 112445.
  167. B. I. Escudero-Abarca, S. H. Suh, M. D. Moore, H. P. Dwivedi, L.-A. Jaykus, PLoS One 2014, 9, e106805.
  168. J. Kirkegaard, N. Rozlosnik, Methods Mol. Biol. 2017, 1572, 55.
  169. A. R. Fehr, R. Channappanavar, S. Perlman, Annu. Rev. Med. 2017, 68, 387.
  170. L. Qin, P. B. Gilbert, L. Corey, M. J. McElrath, S. G. Self, J. Infect. Dis. 2007, 196, 1304.
  171. W. Xu, D. Wang, D. Li, C. C. Liu, Int. J. Mol. Sci. 2019, 21, 134.
  172. R. Racine, G. M. Winslow, Immunol. Lett. 2009, 125, 79.
  173. S. Shukla, S.-Y. Hong, S. H. Chung, M. Kim, Front. Microbiol. 2016, 7, 1685.
  174. G. Cabral-Miranda, A. R. Cardoso, L. C. S. Ferreira, M. G. F. Sales, M. F. Bachmann, Biosens. Bioelectron. 2018, 113, 101.
  175. Z. Chen, Z. Zhang, X. Zhai, Y. Li, L. Lin, H. Zhao, L. Bian, P. Li, L. Yu, Y. Wu, G. Lin, Anal. Chem. 2020, 92, 7226.
  176. L. Pan, M. Mu, P. Yang, Y. Sun, R. Wang, J. Yan, P. Li, B. Hu, J. Wang, C. Hu, Y. Jin, X. Niu, R. Ping, Y. Du, T. Li, G. Xu, Q. Hu, L. Tu, Am. J. Gastroenterol. 2020, 115, 766.
  177. A. de la Escosura-Muñiz, M. Maltez-da Costa, C. Sánchez-Espinel, B. Díaz-Freitas, J. Fernández-Suarez, Á. González-Fernández, A. Merkoçi, Biosens. Bioelectron. 2010, 26, 1710.
  178. J. Highton, Aust. N. Z. J. Med. 1984, 14, 173.
  179. J. R. Dunkelberger, W.-C. Song, Cell Res. 2010, 20, 34.
  180. C. A. Janeway, R. Medzhitov, Annu. Rev. Immunol. 2002, 20, 197.
  181. D. Blanco-Melo, B. E. Nilsson-Payant, W.-C. Liu, S. Uhl, D. Hoagland, R. Møller, T. X. Jordan, K. Oishi, M. Panis, D. Sachs, T. T. Wang, R. E. Schwartz, J. K. Lim, R. A. Albrecht, B. R. TenOever, Cell 2020, 181, 1036.
  182. L. Berman, K. Hargreaves, in Cohen's Pathways Pulp, Elsevier, 12th Ed., Amsterdam 2020, p. 928.
  183. T. Yusa, K. Tateda, A. Ohara, S. Miyazaki, J. Infect. Chemother. 2017, 23, 96.
  184. E. Terpos, I. Ntanasis-Stathopoulos, I. Elalamy, E. Kastritis, T. N. Sergentanis, M. Politou, T. Psaltopoulou, G. Gerotziafas, M. A. Dimopoulos, Am. J. Hematol. 2020, 95, 834.
  185. T. Herold, V. Jurinovic, C. Arnreich, B. J. Lipworth, J. C. Hellmuth, M. von Bergwelt-Baildon, M. Klein, T. Weinberger, J. Allergy Clin. Immunol. 2020, 146, 128.
  186. D. Ragab, H. Salah Eldin, M. Taeimah, R. Khattab, R. Salem, Front. Immunol. 2020, 11, 1446.
  187. N. Chen, M. Zhou, X. Dong, J. Qu, F. Gong, Y. Han, Y. Qiu, J. Wang, Y. Liu, Y. Wei, J. Xia, T. Yu, X. Zhang, L. Zhang, Lancet 2020, 395, 507.
  188. A. Gowri, N. Ashwin Kumar, B. S. Suresh Anand, TrAC, Trends Anal. Chem. 2021, 137, 116205.
  189. Y. Wang, J. Sun, Y. Hou, C. Zhang, D. Li, H. Li, M. Yang, C. Fan, B. Sun, Biosens. Bioelectron. 2019, 141, 111432.
  190. R. Nie, J. Huang, X. Xu, L. Yang, Anal. Bioanal. Chem. 2020, 412, 3231.
  191. K. M. Mayer, J. H. Hafner, Chem. Rev. 2011, 111, 3828.
  192. P. Chen, M. T. Chung, W. McHugh, R. Nidetz, Y. Li, J. Fu, T. T. Cornell, T. P. Shanley, K. Kurabayashi, ACS Nano 2015, 9, 4173.
  193. H. Wei, S. Ni, C. Cao, G. Yang, G. Liu, ACS Sens. 2018, 3, 1553.
  194. M. Garg, A. L. Sharma, S. Singh, Biosens. Bioelectron. 2021, 171, 112703.
  195. A. Stambaugh, J. W. Parks, M. A. Stott, G. G. Meena, A. R. Hawkins, H. Schmidt, Biomed. Opt. Express 2018, 9, 3725.
  196. G. G. Meena, A. M. Stambaugh, V. Ganjalizadeh, M. A. Stott, A. R. Hawkins, H. Schmidt, APL Photonics 2021, 6, 066101.
  197. U.S. Food and Drug Administration, Center for Devices and Radiological, U.S. Food and Drug Administration. https://www.fda.gov/medical-devices/coronavirus-covid-19-and-medical-devices/home-otc-covid-19-diagnostic-tests, 2021.
  198. Dave Muoio, “FDA gives Cue Health first EUA for at-home, OTC COVID-19 molecular testing,” can be found under https://www.mobihealthnews.com/news/fda-gives-cue-health-first-eua-home-otc-covid-19-molecular-testing, 2021.
  199. G. Ruiz-Vega, M. Soler, L. M. Lechuga, J. Phys. Photonics 2021, 3, 011002.
  200. H. C. Ates, A. K. Yetisen, F. Güder, C. Dincer, Nat. Electron. 2021, 4, 13.
  201. P. Q. Nguyen, L. R. Soenksen, N. M. Donghia, N. M. Angenent-Mari, H. de Puig, A. Huang, R. Lee, S. Slomovic, T. Galbersanini, G. Lansberry, H. M. Sallum, E. M. Zhao, J. B. Niemi, J. J. Collins, Nat. Biotechnol. 2021, 39, 1366.
  202. D. Maier, E. Laubender, A. Basavanna, S. Schumann, F. Güder, G. A. Urban, C. Dincer, ACS Sens. 2019, 4, 2945.

Grants

  1. 404478562/Deutsche Forschungsgemeinschaft
  2. 421356369/Deutsche Forschungsgemeinschaft
  3. 446617142/Deutsche Forschungsgemeinschaft
  4. 13GW0493/Bundesministerium für Bildung und Forschung
  5. 2048283/NSF
  6. R01 HL139605/NIH HHS
  7. GR700029RDA/Keck Start-up to Aran Lab

MeSH Term

Biomarkers
Biosensing Techniques
Communicable Diseases
Humans
Pandemics
Point-of-Care Systems

Chemicals

Biomarkers
Journal Article Review
Article has an altmetric score of 15

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Created with Highcharts 10.0.0biosensorspoint-of-careviralbetterinflammatorybiomarkersimmuneresponselimitationsassaysnext-generationbiosensingtechnologiesSeveralinfectiousdiseasesappearlimitlesssincebeginning21centuryexpandingpandemiclengthsThusextensiveeffortsprovideefficientmeansdiagnosisunderstandingacquiredimmunityimprovedmonitoringcrucialcontrollingspreadinfectionaidingvaccinedevelopmentimprovingpatientoutcomesregardvariousdevelopedrecentlystreamlinepathogendetectionaddressingtraditionalmethodsincludingisothermalamplification-basedsystemslateralflowreviewexploresstate-of-the-artdetectingpathogensserologicalmaterialperspectivediscussingadvantagespotentialregardinganalyticalperformanceclinicalutilityadaptabilityAdditionallyoffersensitivityselectivityeasyhandlingend-usershighlightedemergingexamplepowerednovelsyntheticbiologytoolsclusteredregularlyinterspacedshortpalindromicrepeatsCRISPRCRISPR-associatedproteinsCascombinationintegrateddevicesLastlycurrentchallengesdiscussedroadmapfurtheringadvancedmanagefuturepandemicsprovidedEmergingBiosensingTechnologiesDiagnosticsViralInfectiousDiseasesCRISPR/Castechnologyhosttestingviruses

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