Fuhang Song, Jiansen Hu, Xinwan Zhang, Wei Xu, Jinpeng Yang, Shaoyong Li, Xiuli Xu
Two new cyclized thiolopyrrolone derivatives, namely, thiolopyrrolone A () and 2,2-dioxidothiolutin (), together with the kn own compound, Thiolutin () were identified from a marine-derived sp. BTBU20218885, which was isolated from a mud sample collected from the coastal region of Xiamen, China. Their chemical structures were determined using spectroscopic data, including HRESIMS, 1D and 2D NMR techniques. possessed a unique unsymmetrical sulfur-containing thiolopyrrolone structure. All the compounds were tested for bioactivities against , , Bacille Calmette-Gu��rin (BCG), , and . displayed antibacterial activities against BCG, , and with minimum inhibitory concentration (MIC) values of 10, 10, and 100 ��g/mL, respectively. Thiolutin () showed antibacterial activities against , BCG, , and with MIC values of 6.25, 0.3125, 0.625, and 3.125 ��g/mL, respectively.
