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International journal of molecular sciences
Mar 19, 2022;23 (6):

Regulatory miRNAs in Cardiovascular and Alzheimer's Disease: A Focus on Copper.

Anna Sacco, Fabio Martelli, Amit Pal, Claudia Saraceno, Luisa Benussi, Roberta Ghidoni, Mauro Rongioletti, Rosanna Squitti
Author Information
  1. Anna Sacco: Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy.
  2. Fabio Martelli: Molecular Cardiology Laboratory, IRCCS-Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy. ORCID
  3. Amit Pal: Department of Biochemistry, AIIMS, Kalyani 741245, India. ORCID
  4. Claudia Saraceno: Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy. ORCID
  5. Luisa Benussi: Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy. ORCID
  6. Roberta Ghidoni: Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy. ORCID
  7. Mauro Rongioletti: Department of Laboratory Medicine, Research and Development Division, San Giovanni Calibita Fatebenefratelli Hospital, Isola Tiberina, 00186 Rome, Italy.
  8. Rosanna Squitti: Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy. ORCID
PMID: 35328747 DOI: 10.3390/ijms23063327

Abstract

Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), are key regulators of differentiation and development. In the cell, transcription factors regulate the production of miRNA in response to different external stimuli. Copper (Cu) is a heavy metal and an essential micronutrient with widespread industrial applications. It is involved in a number of vital biological processes encompassing respiration, blood cell line maturation, and immune responses. In recent years, the link between deregulation of miRNAs' functionality and the development of various pathologies as well as cardiovascular diseases (CVDs) has been extensively studied. Alzheimer's disease (AD) is the most common cause of dementia in the elderly with a complex disease etiology, and its link with Cu abnormalities is being increasingly studied. A direct interaction between COMMD1, a regulator of the Cu pathway, and hypoxia-inducible factor (HIF) HIF-1a does exist in ischemic injury, but little information has been collected on the role of Cu in hypoxia associated with AD thus far. The current review deals with this matter in an attempt to structurally discuss the link between miRNA expression and Cu dysregulation in AD and CVDs.

Keywords

Alzheimer’s disease cardiovascular disease copper hypoxia microRNAs

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Grants

  1. (PTC) PTC-19-602325 (RS)/Alzheimer's Association Part the Cloud: Translational Research Funding for Alzheimer's Disease
  2. (Ricerca Corrente, Ricerca Finalizzata RF-12368521)/Italian Ministry of Health
  3. (#446 GGP19035A)/Telethon Foundation
  4. (# 23054)/AFM-Telethon
  5. (Grant #101016072)/EU Horizon 2020 project COVIRNA

MeSH Term

Aged
Alzheimer Disease
Cardiovascular Diseases
Copper
Humans
Hypoxia
MicroRNAs
Transcription Factors

Chemicals

MicroRNAs
Transcription Factors
Copper
Journal Article Review

Word Cloud

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