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Molecular microbiology
05, 2022;117 (5): 973-985.

Two-component sensor histidine kinases of Mycobacterium tuberculosis: Beacons for niche navigation.

Miljan Stupar, Juanelle Furness, Christopher J De Voss, Lendl Tan, Nicholas P West
Author Information
  1. Miljan Stupar: School of Chemistry and Molecular Biosciences, Australian Infectious Disease Research Centre, University of Queensland, Brisbane, Queensland, Australia. ORCID
  2. Juanelle Furness: School of Chemistry and Molecular Biosciences, Australian Infectious Disease Research Centre, University of Queensland, Brisbane, Queensland, Australia. ORCID
  3. Christopher J De Voss: School of Chemistry and Molecular Biosciences, Australian Infectious Disease Research Centre, University of Queensland, Brisbane, Queensland, Australia. ORCID
  4. Lendl Tan: School of Chemistry and Molecular Biosciences, Australian Infectious Disease Research Centre, University of Queensland, Brisbane, Queensland, Australia. ORCID
  5. Nicholas P West: School of Chemistry and Molecular Biosciences, Australian Infectious Disease Research Centre, University of Queensland, Brisbane, Queensland, Australia. ORCID
PMID: 35338720 DOI: 10.1111/mmi.14899

Abstract

Intracellular bacterial pathogens such as Mycobacterium tuberculosis are remarkably adept at surviving within a host, employing a variety of mechanisms to counteract host defenses and establish a protected niche. Constant surveying of the environment is key for pathogenic mycobacteria to discern their immediate location and coordinate the expression of genes necessary for adaptation. Two-component systems efficiently perform this role, typically comprised of a transmembrane sensor kinase and a cytoplasmic response regulator. In this review, we describe the role of two-component systems in bacterial pathogenesis, focusing predominantly on the role of sensor kinases of M. tuberculosis. We highlight important features of sensor kinases in mycobacterial infection, discuss ways in which these signaling proteins sense and respond to environments, and how this is attuned to their intracellular lifestyle. Finally, we discuss recent studies which have identified and characterized inhibitors of two-component sensor kinases toward establishing a new strategy in anti-mycobacterial therapy.

Keywords

Mycobacterium tuberculosis TB antibiotic targets histidine sensor kinase two-component transcriptional regulation

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MeSH Term

Adaptation, Physiological
Bacterial Proteins
Histidine
Histidine Kinase
Humans
Mycobacterium Infections
Mycobacterium tuberculosis

Chemicals

Bacterial Proteins
Histidine
Histidine Kinase
Journal Article Review
Article has an altmetric score of 5

Word Cloud

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