OpenLB
Open Library of Bioscience
Advanced Search
Cells & development
06, 2022;170 203776.

Forces in stem cells and cancer stem cells.

Farhan Chowdhury, Bo Huang, Ning Wang
Author Information
  1. Farhan Chowdhury: School of Mechanical, Aerospace, and Materials Engineering, Southern Illinois University Carbondale, Carbondale, IL 62901, USA. Electronic address: farhan.chowdhury@siu.edu.
  2. Bo Huang: Department of Immunology, Institute of Basic Medical Sciences & State Key Laboratory of Medical Molecular Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China. Electronic address: tjhuangbo@hotmail.com.
  3. Ning Wang: Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. Electronic address: nwangrw@illinois.edu.
PMID: 35346899 DOI: 10.1016/j.cdev.2022.203776

Abstract

Endogenous and exogenous forces are critical in physiology and pathology of the human body. Increasing evidence suggests that these forces, mechanics, and force-associated signaling are essential in regulating functions of living cells. Here we review advances in understanding the impact of forces and mechanics on functions and fate of embryonic stem cells, adult stem cells, and cancer stem cells and the pathways of mechanotransduction in cells. Stem-cells based models are useful in understanding how forces influence physiology, pathology, and embryonic development, which is incompletely understood, especially for mammals. We highlight increasing efforts and emerging favorable clinical outcomes in mechanomedicine, application of mechanobiology to medicine. Major progresses in mechanobiology, the pillar of mechanomedicine and mechanohealth (application of mechanobiology to health), are pivotal in understanding the life of force and making substantial advances in medicine and health.

Keywords

Adult stem cells Embryogenesis Force Gastrulation Pluripotent stem cells

References

  1. Nat Commun. 2020 Jan 31;11(1):665 [PMID: 32005801]
  2. Cell. 2009 Nov 25;139(5):891-906 [PMID: 19931152]
  3. Nat Cell Biol. 2019 Feb;21(2):275-286 [PMID: 30598530]
  4. Science. 2009 Jan 30;323(5914):642-4 [PMID: 19179533]
  5. Nat Cell Biol. 2015 May;17(5):678-88 [PMID: 25893917]
  6. Nat Mater. 2020 Feb;19(2):239-250 [PMID: 31659296]
  7. Nat Commun. 2015 Feb 23;6:6333 [PMID: 25704457]
  8. Science. 2016 Apr 15;352(6283):353-8 [PMID: 27013428]
  9. Nature. 2018 Sep;561(7723):401-405 [PMID: 30185907]
  10. Blood. 2006 Mar 15;107(6):2548-56 [PMID: 16291597]
  11. J Immunol. 2013 May 1;190(9):4661-75 [PMID: 23554309]
  12. Nat Mater. 2010 Jan;9(1):82-8 [PMID: 19838182]
  13. Cell. 2008 May 16;133(4):704-15 [PMID: 18485877]
  14. Nature. 2008 Dec 4;456(7222):593-8 [PMID: 19052619]
  15. Development. 1988 May;103(1):193-209 [PMID: 3197629]
  16. Nat Biomed Eng. 2022 Jan;6(1):54-66 [PMID: 34083763]
  17. J Cell Biol. 2019 Aug 5;218(8):2545-2563 [PMID: 31239284]
  18. Nat Methods. 2014 Aug;11(8):847-54 [PMID: 24973948]
  19. Nat Biomed Eng. 2021 Aug;5(8):815-829 [PMID: 33941899]
  20. Stem Cells. 2018 Feb;36(2):265-277 [PMID: 29086457]
  21. Theranostics. 2021 Apr 15;11(13):6138-6153 [PMID: 33995650]
  22. Nat Mater. 2012 Jul 01;11(8):734-41 [PMID: 22751180]
  23. Phys Rev Lett. 2001 Oct 1;87(14):148102 [PMID: 11580676]
  24. Proc Natl Acad Sci U S A. 1978 May;75(5):2324-8 [PMID: 276875]
  25. Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):855-9 [PMID: 7846066]
  26. Cell Rep. 2021 Apr 13;35(2):108990 [PMID: 33852841]
  27. Science. 2003 Jun 20;300(5627):1957-61 [PMID: 12750478]
  28. Blood. 2015 Jan 15;125(3):542-52 [PMID: 25411427]
  29. Biophys J. 2011 Aug 3;101(3):575-84 [PMID: 21806925]
  30. Nat Methods. 2014 Feb;11(2):183-9 [PMID: 24317254]
  31. Dev Cell. 2020 Dec 21;55(6):679-694.e11 [PMID: 33207224]
  32. Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14347-52 [PMID: 18794520]
  33. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11349-54 [PMID: 23798429]
  34. Cell. 2010 Sep 3;142(5):773-86 [PMID: 20813263]
  35. Cell Stem Cell. 2014 Aug 7;15(2):154-68 [PMID: 24953181]
  36. J Cell Sci. 2006 Feb 1;119(Pt 3):508-18 [PMID: 16443749]
  37. Dev Cell. 2008 Sep;15(3):470-477 [PMID: 18804441]
  38. Nat Commun. 2017 Jan 23;8:13883 [PMID: 28112149]
  39. Cell. 2006 Aug 25;126(4):663-76 [PMID: 16904174]
  40. Philos Trans R Soc Lond B Biol Sci. 2019 Aug 19;374(1779):20180217 [PMID: 31431181]
  41. Sci Transl Med. 2009 Nov 25;1(8):8ra19 [PMID: 20368186]
  42. Science. 2020 Oct 30;370(6516): [PMID: 33122355]
  43. Dev Genes Evol. 2000 Feb;210(2):92-104 [PMID: 10664152]
  44. Curr Biol. 2011 Feb 8;21(3):236-42 [PMID: 21276726]
  45. Nature. 2013 May 23;497(7450):507-11 [PMID: 23644458]
  46. Science. 1998 Nov 6;282(5391):1145-7 [PMID: 9804556]
  47. Cell. 2020 May 14;181(4):800-817.e22 [PMID: 32302590]
  48. Science. 2013 Jun 28;340(6140):1587-90 [PMID: 23686338]
  49. Semin Cell Dev Biol. 2020 Apr;100:199-211 [PMID: 31734039]
  50. Cell. 2017 Nov 30;171(6):1397-1410.e14 [PMID: 29107331]
  51. Nat Biomed Eng. 2021 Dec;5(12):1485-1499 [PMID: 33875841]
  52. Elife. 2021 Apr 19;10: [PMID: 33871354]
  53. Nat Biomed Eng. 2021 Dec;5(12):1411-1425 [PMID: 34873307]
  54. Nat Biomed Eng. 2021 Dec;5(12):1437-1456 [PMID: 34031559]
  55. Biophys J. 2010 Jul 21;99(2):L19-21 [PMID: 20643049]
  56. Nat Cell Biol. 2014 Apr;16(4):376-81 [PMID: 24609268]
  57. Curr Biol. 2020 Sep 7;30(17):3364-3377.e4 [PMID: 32679105]
  58. Sci Adv. 2020 Mar 11;6(11):eaaz4157 [PMID: 32195352]
  59. iScience. 2021 Jan 28;24(2):102113 [PMID: 33659878]
  60. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3983-8 [PMID: 12629218]
  61. J Immunol. 2014 Jul 1;193(1):68-76 [PMID: 24890718]
  62. Cancer Res. 2003 Sep 15;63(18):5821-8 [PMID: 14522905]
  63. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17253-8 [PMID: 24101477]
  64. Cell Cycle. 2017 Jul 18;16(14):1328-1335 [PMID: 28590839]
  65. Cell Stem Cell. 2011 Oct 4;9(4):357-65 [PMID: 21982235]
  66. PLoS One. 2011 May 10;6(5):e19680 [PMID: 21572959]
  67. Nature. 1981 Jul 9;292(5819):154-6 [PMID: 7242681]
  68. N Engl J Med. 1986 Dec 25;315(26):1650-9 [PMID: 3537791]
  69. Nat Commun. 2014 May 30;5:4000 [PMID: 24873804]
  70. Cell Stem Cell. 2021 Feb 4;28(2):209-216.e4 [PMID: 33207217]
  71. Nat Cell Biol. 2017 Mar;19(3):224-237 [PMID: 28218910]
  72. Nat Methods. 2018 Jul;15(7):491-498 [PMID: 29915189]
  73. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14645-50 [PMID: 20679233]
  74. Curr Biol. 2017 Jul 24;27(14):2065-2077.e6 [PMID: 28669759]
  75. J Clin Invest. 2004 Feb;113(3):370-8 [PMID: 14755334]
  76. Nat Mater. 2015 Oct;14(10):1040-8 [PMID: 26237129]
  77. Nat Cell Biol. 2020 Jul;22(7):791-802 [PMID: 32483386]
  78. Nature. 2011 Jun 08;474(7350):179-83 [PMID: 21654799]
  79. EMBO J. 2021 May 3;40(9):e106113 [PMID: 33604918]
  80. Biophys J. 2005 May;88(5):3689-98 [PMID: 15722433]
  81. Nat Med. 1997 Jul;3(7):730-7 [PMID: 9212098]
  82. Sci Adv. 2020 Apr 01;6(14):eaay9095 [PMID: 32270037]
  83. Elife. 2018 Mar 13;7: [PMID: 29533180]
  84. Biotechnol Bioeng. 2004 Nov 5;88(3):359-68 [PMID: 15486942]
  85. Cancer Res. 2021 Jan 15;81(2):476-488 [PMID: 33168645]
  86. Development. 2015 Feb 15;142(4):692-701 [PMID: 25670794]
  87. Cell Stem Cell. 2021 Jan 7;28(1):63-78.e7 [PMID: 33053374]
  88. Nat Cell Biol. 2008 Dec;10(12):1401-10 [PMID: 18978783]
  89. Nat Rev Mol Cell Biol. 2019 Feb;20(2):69-84 [PMID: 30459476]
  90. PLoS One. 2018 May 23;13(5):e0198026 [PMID: 29791489]
  91. Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12407-12 [PMID: 9356462]
  92. APMIS. 2005 Nov-Dec;113(11-12):756-72 [PMID: 16480448]
  93. Cell Stem Cell. 2016 Jun 2;18(6):782-796 [PMID: 27053299]
  94. Dev Cell. 2019 Jun 17;49(6):920-935.e5 [PMID: 31105008]
  95. Science. 2010 Aug 27;329(5995):1078-81 [PMID: 20647425]
  96. Nat Biomed Eng. 2022 Jan 3;: [PMID: 34980903]
  97. Cytoskeleton (Hoboken). 2021 Jun;78(6):249-276 [PMID: 33754478]
  98. Nat Mater. 2020 Apr;19(4):464-473 [PMID: 31844279]
  99. Nat Protoc. 2017 Jun;12(6):1177-1197 [PMID: 28492526]
  100. Acta Biomater. 2021 Oct 23;: [PMID: 34700042]
  101. Dev Dyn. 1996 Oct;207(2):145-56 [PMID: 8906418]
  102. Adv Healthc Mater. 2020 Apr;9(8):e1901373 [PMID: 32090507]
  103. Biomaterials. 2005 May;26(15):2455-65 [PMID: 15585248]
  104. PLoS One. 2010 Dec 13;5(12):e15655 [PMID: 21179449]
  105. PLoS Genet. 2014 Feb 20;10(2):e1004114 [PMID: 24586179]
  106. Nature. 2021 Mar;591(7851):620-626 [PMID: 33731924]
  107. Nat Cell Biol. 2009 Jul;11(7):859-64 [PMID: 19503074]
  108. Stem Cell Rev Rep. 2021 Dec;17(6):1975-1992 [PMID: 34115316]
  109. Nat Mater. 2013 Dec;12(12):1154-62 [PMID: 24141451]
  110. Development. 2016 Jan 15;143(2):186-96 [PMID: 26786209]
  111. Sci Adv. 2020 Dec 4;6(49): [PMID: 33277245]
  112. Proc Natl Acad Sci U S A. 2021 Nov 30;118(48): [PMID: 34810266]
  113. Cancer Res. 2005 Apr 15;65(8):3025-9 [PMID: 15833827]
  114. Stem Cells. 2017 Feb;35(2):497-506 [PMID: 27573749]
  115. Cancer Res. 2005 Dec 1;65(23):10946-51 [PMID: 16322242]
  116. Biophys J. 2010 Jul 7;99(1):115-23 [PMID: 20655839]
  117. Nat Commun. 2020 Jun 1;11(1):2713 [PMID: 32483127]
  118. Curr Opin Biotechnol. 2007 Oct;18(5):460-6 [PMID: 18023337]
  119. Cell Death Differ. 2008 Mar;15(3):504-14 [PMID: 18049477]
  120. Nat Rev Cancer. 2008 Oct;8(10):755-68 [PMID: 18784658]
  121. Cell. 2006 Aug 25;126(4):677-89 [PMID: 16923388]
  122. Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22111-6 [PMID: 21127270]
  123. Cancer Res. 2005 Oct 15;65(20):9328-37 [PMID: 16230395]
  124. Proc Natl Acad Sci U S A. 2011 May 10;108(19):7950-5 [PMID: 21498687]
  125. Nature. 2018 Apr;556(7700):239-243 [PMID: 29618819]
  126. Science. 2010 Oct 1;330(6000):55-60 [PMID: 20813920]
  127. Nat Cell Biol. 2015 May;17(5):533-9 [PMID: 25925582]
  128. Nat Commun. 2018 May 14;9(1):1878 [PMID: 29760452]
  129. Science. 2019 Aug 2;365(6452):465-468 [PMID: 31371608]
  130. Nat Mater. 2016 Mar;15(3):326-34 [PMID: 26618884]
  131. Nature. 2020 Sep;585(7825):433-439 [PMID: 32879493]
  132. Elife. 2019 Dec 09;8: [PMID: 31815664]
  133. Nature. 2019 Sep;573(7774):421-425 [PMID: 31511693]
  134. Nat Commun. 2018 Apr 11;9(1):1406 [PMID: 29643385]
  135. Sci Rep. 2016 Jan 20;6:19304 [PMID: 26787224]
  136. Circ Res. 2003 Aug 22;93(4):330-7 [PMID: 12893741]
  137. PLoS One. 2018 Jul 10;13(7):e0199151 [PMID: 29990323]
  138. Science. 2021 Sep 24;373(6562):1537-1540 [PMID: 34554778]
  139. Dev Cell. 2021 Jun 7;56(11):1574-1588.e7 [PMID: 33932333]
  140. Nature. 2021 Mar;591(7851):627-632 [PMID: 33731926]
  141. Sci Rep. 2021 Jun 8;11(1):12106 [PMID: 34103554]
  142. Nat Cell Biol. 2015 Dec;17(12):1597-606 [PMID: 26523364]
  143. EMBO J. 2021 Jan 15;40(2):e106123 [PMID: 33274785]
  144. Development. 2008 Aug;135(14):2435-44 [PMID: 18550716]
  145. Nat Nanotechnol. 2007 Dec;2(12):780-3 [PMID: 18654431]
  146. Nat Rev Mol Cell Biol. 2022 Mar;23(3):169-184 [PMID: 34754086]
  147. Nat Med. 2011 Mar;17(3):320-9 [PMID: 21383745]
  148. Nature. 2010 Jul 8;466(7303):263-6 [PMID: 20613844]
  149. Nature. 1994 Feb 17;367(6464):645-8 [PMID: 7509044]
  150. Cell. 2020 Oct 1;183(1):28-45 [PMID: 32976797]
  151. Nat Med. 2014 Mar;20(3):255-64 [PMID: 24531378]
  152. Nat Commun. 2020 Oct 7;11(1):5053 [PMID: 33028821]
  153. NPJ Precis Oncol. 2021 Jun 29;5(1):62 [PMID: 34188163]
  154. Cancer Res. 2018 Jul 15;78(14):3926-3937 [PMID: 29764867]
  155. J Cell Physiol. 2019 May;234(5):7569-7578 [PMID: 30368818]
  156. Nature. 2004 Jun 10;429(6992):667-71 [PMID: 15190355]
  157. Nat Commun. 2012 May 29;3:866 [PMID: 22643893]
  158. Nature. 2019 Sep;573(7772):69-74 [PMID: 31435009]
  159. Stem Cell Reports. 2021 Jun 8;16(6):1398-1408 [PMID: 34048692]
  160. Proc Natl Acad Sci U S A. 1981 Dec;78(12):7634-8 [PMID: 6950406]
  161. Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):133-138 [PMID: 29255056]
  162. Science. 2013 Aug 30;341(6149):1240104 [PMID: 23990565]
  163. APL Bioeng. 2021 Oct 13;5(4):041503 [PMID: 34661040]
  164. Elife. 2019 Jan 15;8: [PMID: 30642430]
  165. Science. 2020 Nov 27;370(6520): [PMID: 33243859]
  166. Science. 2009 Jan 30;323(5914):638-41 [PMID: 19179532]
  167. Development. 2013 Oct;140(19):4051-9 [PMID: 24046320]
  168. Proc Natl Acad Sci U S A. 2021 Dec 7;118(49): [PMID: 34845026]
  169. Sci Immunol. 2019 Mar 22;4(33): [PMID: 30902904]
  170. Nat Commun. 2021 Oct 21;12(1):6132 [PMID: 34675200]
  171. Cell. 2007 Nov 30;131(5):861-72 [PMID: 18035408]
  172. Nat Cancer. 2022 Jan;3(1):90-107 [PMID: 35121989]
  173. Nat Cell Biol. 2018 Apr;20(4):373-381 [PMID: 29467443]
  174. Stem Cell Res. 2019 Dec;41:101614 [PMID: 31715427]
  175. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11307-12 [PMID: 11027332]
  176. Nat Nanotechnol. 2012 Nov;7(11):757-65 [PMID: 23085644]
  177. Circulation. 2016 Nov 15;134(20):1557-1567 [PMID: 27737958]
  178. Nature. 2021 Dec;600(7890):690-694 [PMID: 34880503]
  179. Nat Mater. 2007 Dec;6(12):997-1003 [PMID: 17891143]
  180. Trends Cell Biol. 2021 Jun;31(6):457-472 [PMID: 33712293]
  181. J Biol Chem. 2004 Oct 1;279(40):41263-6 [PMID: 15292239]
  182. Nat Commun. 2014 Aug 06;5:4619 [PMID: 25099074]
  183. Sci Rep. 2013;3:1087 [PMID: 23336069]
  184. ACS Biomater Sci Eng. 2019 Aug 12;5(8):3876-3888 [PMID: 33438427]
  185. Nat Mater. 2016 Dec;15(12):1287-1296 [PMID: 27548707]
  186. Dev Cell. 2017 Feb 27;40(4):354-366.e4 [PMID: 28216382]
  187. Cell. 2016 Mar 24;165(1):100-110 [PMID: 26924577]
  188. Acta Mech Sin. 2019;35(2):270-274 [PMID: 31736534]
  189. Nature. 2005 Sep 15;437(7057):426-31 [PMID: 16163360]
  190. Curr Opin Genet Dev. 2006 Aug;16(4):392-8 [PMID: 16782324]
  191. Front Oncol. 2021 Dec 20;11:788365 [PMID: 34988021]
  192. Biophys J. 2008 Dec 15;95(12):5719-27 [PMID: 18835892]
  193. PLoS One. 2017 Aug 17;12(8):e0183174 [PMID: 28817635]
  194. Differentiation. 2003 Apr;71(3):171-205 [PMID: 12694202]
  195. Nat Mater. 2018 Jul;17(7):633-641 [PMID: 29784997]
  196. Nat Commun. 2021 Apr 21;12(1):2359 [PMID: 33883558]
  197. J Cell Biol. 2010 Jun 28;189(7):1107-15 [PMID: 20584916]
  198. Nat Methods. 2017 Feb;14(2):181-186 [PMID: 27918540]
  199. Proc Natl Acad Sci U S A. 2021 Dec 21;118(51): [PMID: 34916290]
  200. Oncogene. 2019 Oct;38(42):6818-6834 [PMID: 31406247]
  201. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16095-100 [PMID: 17060641]
  202. Angle Orthod. 2004 Feb;74(1):3-15 [PMID: 15038485]
  203. Nat Commun. 2020 Jan 21;11(1):404 [PMID: 31964880]
  204. Integr Biol (Camb). 2010 Sep;2(9):435-42 [PMID: 20725677]
  205. Cell Res. 2016 Jun;26(6):713-27 [PMID: 27167569]
  206. Sci Rep. 2015 Sep 22;5:14218 [PMID: 26391588]
  207. Science. 2007 Dec 21;318(5858):1917-20 [PMID: 18029452]
  208. Nat Phys. 2018 Jun;14:613-620 [PMID: 30151030]
  209. Tissue Eng Part A. 2009 Jan;15(1):147-54 [PMID: 18673086]
  210. Science. 2012 Aug 10;337(6095):738-42 [PMID: 22767894]

Grants

  1. R01 GM072744/NIGMS NIH HHS
  2. R15 GM140448/NIGMS NIH HHS

MeSH Term

Adult Stem Cells
Animals
Embryonic Development
Humans
Mammals
Mechanotransduction, Cellular
Neoplasms
Neoplastic Stem Cells
Signal Transduction
Journal Article Review Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't
Article has an altmetric score of 2

Word Cloud

Created with Highcharts 10.0.0cellsstemforcesunderstandingmechanobiologyphysiologypathologymechanicsfunctionsadvancesembryoniccancermechanomedicineapplicationmedicinehealthEndogenousexogenouscriticalhumanbodyIncreasingevidencesuggestsforce-associatedsignalingessentialregulatinglivingreviewimpactfateadultpathwaysmechanotransductionStem-cellsbasedmodelsusefulinfluencedevelopmentincompletelyunderstoodespeciallymammalshighlightincreasingeffortsemergingfavorableclinicaloutcomesMajorprogressespillarmechanohealthpivotallifeforcemakingsubstantialForcesAdultEmbryogenesisForceGastrulationPluripotent

Similar Articles

Cited By