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Respiratory research
Mar 31, 2022;23 (1): 77.

Association of air pollution exposure with exercise-induced oxygen desaturation in COPD.

Kang-Yun Lee, Sheng-Ming Wu, Hsiao-Yun Kou, Kuan-Yuan Chen, Hsiao-Chi Chuang, Po-Hao Feng, Kian Fan Chung, Kazuhiro Ito, Tzu-Tao Chen, Wei-Lun Sun, Wen-Te Liu, Chien-Hua Tseng, Shu-Chuan Ho
Author Information
  1. Kang-Yun Lee: Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
  2. Sheng-Ming Wu: Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
  3. Hsiao-Yun Kou: School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan.
  4. Kuan-Yuan Chen: Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
  5. Hsiao-Chi Chuang: Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
  6. Po-Hao Feng: Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
  7. Kian Fan Chung: National Heart and Lung Institute, Imperial College London, London, UK.
  8. Kazuhiro Ito: National Heart and Lung Institute, Imperial College London, London, UK.
  9. Tzu-Tao Chen: Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
  10. Wei-Lun Sun: Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
  11. Wen-Te Liu: Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
  12. Chien-Hua Tseng: Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
  13. Shu-Chuan Ho: Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan. shu-chuan@tmu.edu.tw. ORCID
PMID: 35361214 DOI: 10.1186/s12931-022-02000-1

Abstract

BACKGROUND: There is a link between exposure to air pollution and the increased prevalence of chronic obstructive pulmonary disease (COPD) and declining pulmonary function, but the association with O desaturation during exercise in COPD patients with emphysema is unclear. Our aims were to estimate the prevalence of O desaturation during exercise in patients with COPD, and determine the association of exposure to air pollution with exercise-induced desaturation (EID), the degree of emphysema, and dynamic hyperinflation (DH).
METHODS: We assessed the effects of 10-year prior to the HRCT assessment and 7 days prior to the six-minute walking test exposure to particulate matter with an aerodynamic diameter of < 10 µm (PM) or of < 2.5 µM (PM, nitrogen dioxide (NO), and ozone (O) in patients with emphysema in this retrospective cohort study. EID was defined as a nadir standard pulse oximetry (SpO) level of < 90% or a delta (△)SpO level of ≥ 4%. Ambient air pollutant (PM, PM, O, and NO) data were obtained from Taiwan Environmental Protection Administration (EPA) air-monitoring stations, usually within 10 km to each participant's home address.
RESULTS: We recruited 141 subjects with emphysema. 41.1% of patients with emphysema exhibited EID, and patients with EID had more dyspnea, worse lung function, more severe emphysema, more frequent acute exacerbations, managed a shorter walking distance, had DH, and greater long-term exposure to air pollution than those without EID. We observed that levels of 10-year concentrations of PM, PM, and NO were significantly associated with EID, PM and PM were associated with the severity of emphysema, and associated with DH in patients with emphysema. In contrast, short-term exposure did not have any effect on patients.
CONCLUSION: Long-term exposure to ambient PM, PM and NO, but not O, was associated with EID.

Keywords

Air pollution COPD Dynamic hyperinflation (DH) Emphysema Exercise-induced desaturation (EID) Low attenuation area (LAA)

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Grants

  1. 108-2314-B-038-113-MY3/Ministry of Science and Technology
  2. DP2-110-21121-01-T-01-05/Ministry of Education
  3. 110TMU-SHH-05/Taipei Medical University Hospital

MeSH Term

Air Pollution
Exercise
Humans
Ozone
Pulmonary Disease, Chronic Obstructive
Retrospective Studies

Chemicals

Ozone
Journal Article
Article has an altmetric score of 1

Word Cloud

Created with Highcharts 10.0.0PMemphysemaEIDexposurepatientsairpollutionCOPDOdesaturationDHNOassociatedprevalencepulmonaryfunctionassociationexerciseexercise-inducedhyperinflation10-yearpriorwalkingSpOlevelBACKGROUND:linkincreasedchronicobstructivediseasedecliningunclearaimsestimatedeterminedegreedynamicMETHODS:assessedeffectsHRCTassessment7 dayssix-minutetestparticulatematteraerodynamicdiameterof < 10 µmof < 25 µMnitrogendioxideozoneretrospectivecohortstudydefinednadirstandardpulseoximetryof < 90%delta△of ≥ 4%AmbientpollutantdataobtainedTaiwanEnvironmentalProtectionAdministrationEPAair-monitoringstationsusuallywithin10 kmparticipant'shomeaddressRESULTS:recruited141subjects411%exhibiteddyspneaworselungseverefrequentacuteexacerbationsmanagedshorterdistancegreaterlong-termwithoutobservedlevelsconcentrationssignificantlyseveritycontrastshort-termeffectCONCLUSION:Long-termambientAssociationoxygenAirDynamicEmphysemaExercise-inducedLowattenuationareaLAA

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