Pre-exposure Prophylaxis (PrEP) Initiation Among Black and Latina Cisgender Women Receiving HIV Prevention Care Coordination Services in New York City.

Jelani B Cheek, Matthew B Feldman, Noelisa Montero, Gina F Gambone, Susie Hoffman, Oni J Blackstock
Author Information
  1. Jelani B Cheek: New York City Department of Health and Mental Hygiene, Division of Disease Control, Bureau of Hepatitis, HIV, and Sexually Transmitted Infections, 42-09 28th Street, Queens, Long Island City, NY, 11101-4132, USA. jcheek@health.nyc.gov. ORCID
  2. Matthew B Feldman: New York City Department of Health and Mental Hygiene, Division of Disease Control, Bureau of Hepatitis, HIV, and Sexually Transmitted Infections, 42-09 28th Street, Queens, Long Island City, NY, 11101-4132, USA.
  3. Noelisa Montero: New York City Department of Health and Mental Hygiene, Division of Disease Control, Bureau of Hepatitis, HIV, and Sexually Transmitted Infections, 42-09 28th Street, Queens, Long Island City, NY, 11101-4132, USA.
  4. Gina F Gambone: New York City Department of Health and Mental Hygiene, Division of Disease Control, Bureau of Hepatitis, HIV, and Sexually Transmitted Infections, 42-09 28th Street, Queens, Long Island City, NY, 11101-4132, USA.
  5. Susie Hoffman: Division of Gender, Sexuality, and Health, Department of Psychiatry, HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute and Columbia University, New York, NY, USA.
  6. Oni J Blackstock: New York City Department of Health and Mental Hygiene, Division of Disease Control, Bureau of Hepatitis, HIV, and Sexually Transmitted Infections, 42-09 28th Street, Queens, Long Island City, NY, 11101-4132, USA.

Abstract

Black and Latina cisgender women are disproportionately impacted by HIV in the US. Although PrEP is effective at preventing HIV infection, uptake in this population remains low. The aim of the study was to examine sociodemographic, behavioral, clinical, and psychosocial factors associated with PrEP initiation (defined as receiving a PrEP prescription) among 565 cisgender women enrolled in an HIV prevention services coordination program in NYC from January 2017 to December 2019 who met HIV risk criteria for PrEP. Of these, 26% initiated PrEP. Latina women were significantly more likely than white women to have initiated PrEP (Latina: 29.7%; Black: 26.1%; White: 16.3%; Other: 7.4%). PrEP initiation was significantly associated with PrEP awareness, an annual income < $20,000, being unstably housed, receiving benefits navigation services, and reporting non-injection drug use and/or a recent sexual relationship with an HIV-positive partner. The relatively low rate of PrEP initiation we observed suggests the need to increase PrEP access and uptake among women, particularly Black and Latina women who continue to be disproportionately at risk for HIV.

Keywords

References

  1. Centers for Disease Control and Prevention. HIV surveillance report, 2018 (updated). Available from:  http://www.cdc.gov/hiv/library/reports/hiv-surveillance.html . Accessed 30 Sep 2021.
  2. Huang YA, Zhu WK, Smith DW, Harris N, Hoover K. HIV preexposure prophylaxis, by race and ethnicity—United States, 2014–2016. MMWR Morb Mortal Wkly Rep. 2018;67(41):1147–50. [PMID: 30335734]
  3. Bush S, Rawlings K, Magnuson D, Martin P, Lugo-Torres O, Mera-Giler R. Utilization of emtricitabine/tenofovir (FTC/TDF) for HIV pre-exposure prophylaxis in the United States by gender (2013–1Q2016) International Congress of Drug Therapy in HIV Infection. Glasgow, UK. Abs O314. 2016
  4. Theodore DA, Zucker J, Carnevale C, et al. Pre-exposure prophylaxis use among predominantly African American and Hispanic women at risk for HIV acquisition in New York City. J Assoc Nurses AIDS Care. 2020;31(1):110–4. [PMID: 31789687]
  5. Blackstock OJ, Patel VV, Felsen U, Park C, Jain S. Pre-exposure prophylaxis prescribing and retention in care among heterosexual women at a community-based comprehensive sexual health clinic. AIDS Care. 2017;29(7):866–9. [PMID: 28147704]
  6. Park CJ, Taylor TN, Gutierrez NR, Zingman BS, Blackstock OJ. Pathways to HIV pre-exposure prophylaxis among women prescribed PrEP at an urban sexual health clinic. J Assoc Nurses AIDS Care. 2019;30(3):321–9. [PMID: 30958408]
  7. Wingood GM, Dunkle K, Camp C, et al. Racial differences and correlates of potential adoption of preexposure prophylaxis. J Acquir Immune Defic Syndr. 2013;63(Suppl 1):S95–101. [PMID: 23673895]
  8. Willie TC, Stockman JK, Keene DE, Calabrese SK, Alexander KA, Kershaw TS. Social networks and its impact on women’s awareness, interest, and uptake of HIV pre-exposure prophylaxis (PrEP): implications for women experiencing intimate partner violence. J Acquir Immune Defic Syndr. 2019;80(4):386–93. [PMID: 30570528]
  9. Calabrese SK, Dovidio JF, Tekeste M, et al. HIV pre-exposure prophylaxis stigma as a multidimensional barrier to uptake among women who attend planned parenthood. J Acquir Immune Defic Syndr. 2018;79(1):46–53. [PMID: 29847480]
  10. Sales JM, Sheth AN. Associations among perceived HIV risk, behavioral risk and interest in PrEP among black women in the Southern US. AIDS Behav. 2018;23(7):1871–6. [DOI: 10.1007/s10461-018-2333-9]
  11. Carley T, Siewert E, Naresh A. Interest in pre-exposure prophylaxis (PrEP) for HIV is limited among women in a general obstetrics and gynecology setting. AIDS Behav. 2019;23(10):2741–8. [PMID: 31065923]
  12. Nwogwugwu C, Hossain M, Bronner Y, Ogbolu Y. Examining the health belief model risk factors on PrEP use among African-American women ages 20–44. J Natl Black Nurses Assoc. 2019;30(2):18–25. [PMID: 32176965]
  13. Garfinkel DB, Alexander KA, McDonald-Mosley R, Willie TC, Decker MR. Predictors of HIV-related risk perception and PrEP acceptability among young adult female family planning patients. AIDS Care. 2016;29(6):751–8. [PMID: 27680304]
  14. Rubtsova A, Wingood G, Dunkle K, Camp C, DiClemente R. Young adult women and correlates of potential adoption of pre-exposure prophylaxis (PrEP): results of a national survey. Curr HIV Res. 2014;11(7):543–8. [DOI: 10.2174/1570162X12666140129104952]
  15. Mangum LC, Craddock JB, Whitfield DL. Associations in preventive sexual health service utilization and pre-exposure prophylaxis (PrEP) interest among young black women in the United States. AIDS Care. 2018;2021:1–7.
  16. Willie TC, Stockman JK, Overstreet NM, Kershaw TS. Examining the impact of intimate partner violence type and timing on pre-exposure prophylaxis awareness, interest, and coercion. AIDS Behav. 2017;22(4):1190–200. [DOI: 10.1007/s10461-017-1901-8]
  17. Villalba K, Jean-Gilles M, Rosenberg R, et al. Understanding the impact of intimate partner violence type and timing on pre-exposure prophylaxis knowledge, acceptability, sexual behavior, and gender roles among women of color. J Interpers Violence. 2021. https://doi.org/10.1177/08862605211001468 . [PMID: 33752483]
  18. Braksmajer A, Leblanc NM, El-Bassel N, Urban MA, McMahon JM. Feasibility and acceptability of pre-exposure prophylaxis use among women in violent relationships. AIDS Care. 2018;31(4):475–80. [PMID: 30045629]
  19. Willie TC, Keene DE, Stockman JK, Alexander KA, Calabrese SK, Kershaw TS. Intimate partner violence influences women’s engagement in the early stages of the HIV pre-exposure prophylaxis (PrEP) care continuum: using doubly robust estimation. AIDS Behav. 2019;24(2):560–7. [DOI: 10.1007/s10461-019-02469-w]
  20. Mayer KH, Agwu A, Malebranche D. Barriers to the wider use of pre-exposure prophylaxis in the United States: a narrative review. Adv Ther. 2020;37(5):1778–811. [PMID: 32232664]
  21. D’Angelo AB, Davis Ewart LN, Koken J, Bimbi D, Brown JT, Grov C. Barriers and facilitators to pre-exposure prophylaxis uptake among black women: a qualitative analysis guided by a socioecological model. J Assoc Nurses AIDS Care. 2021;32(4):481–94. [PMID: 34171885]
  22. Nydegger LA, Dickson-Gomez J, Ko KT. A longitudinal, qualitative exploration of perceived HIV risk, healthcare experiences, and social support as facilitators and barriers to PrEP adoption among black women. AIDS Behav. 2020;25(2):582–91. [DOI: 10.1007/s10461-020-03015-9]
  23. Bond KT, Gunn A, Williams P, Leonard NR. Using an intersectional framework to understand the challenges of adopting pre-exposure prophylaxis (PrEP) among young adult black women. Sex Res Soc Policy. 2022;19:180–93. [DOI: 10.1007/s13178-021-00533-6]
  24. Teitelman AM, Tieu H-V, Flores D, et al. Individual, social and structural factors influencing PrEP uptake among cisgender women: a theory-informed elicitation study. AIDS Care. 2021. https://doi.org/10.1080/09540121.2021.1894319 . [PMID: 33719816]
  25. New York City Department of Health and Mental Hygiene. HIV surveillance report, 2019. Available from: https://www1.nyc.gov/site/doh/data/data-sets/hiv-aids-surveillance-and-epidemiology-reports.page#surv . Accessed 15 Jan 2020.
  26. Garrestson M. NYC Department of Health & Mental Hygiene. (2012–2018). Sexual Health Survey. Presented at: New York City Department of Health and Mental Hygiene; 2019.
  27. New York State Department of Health AIDS Institute. PrEP to prevent HIV and promote sexual health. New York: New York State Department of Health; 2020. Available from: https://www.hivguidelines.org/prep-for-prevention/prep/#tab_2 . Accessed 29 Oct 2020.
  28. Ruxton GD, Neuhäuser M. Review of alternative approaches to calculation of a confidence interval for the odds ratio of a 2 × 2 contingency table. Methods Ecol Evol. 2012;4(1):9–13. [DOI: 10.1111/j.2041-210x.2012.00250.x]
  29. Weber F, Knapp G, Ickstadt K, Kundt G, Glass A. Zero-cell corrections in random-effects meta-analyses. Res Synth Methods. 2020;11(6):913–9. [PMID: 32991790]
  30. Willie TC, Kershaw TS, Blackstock O, et al. Racial and ethnic differences in women’s HIV risk and attitudes towards pre-exposure prophylaxis (PrEP) in the context of the substance use, violence, and depression syndemic. AIDS Care. 2020;33(2):219–28. [PMID: 32408837]
  31. Hirschhorn LR, Brown RN, Friedman EE, et al. Black cisgender women’s PrEP knowledge, attitudes, preferences, and experience in Chicago. J Acquir Immun Defic Syndr. 2020;84:497–507. [DOI: 10.1097/QAI.0000000000002377]
  32. Bien CH, Patel VV, Blackstock OJ, Felsen UR. Reaching key populations: PrEP uptake in an urban health care system in the Bronx, New York. AIDS Behav. 2016;21(5):1309–14. [DOI: 10.1007/s10461-016-1663-8]
  33. Kwakwa HA, Bessias S, Sturgis D, et al. Engaging United States Black communities in HIV pre-exposure prophylaxis: analysis of a PrEP engagement cascade. J Natl Med Assoc. 2018;110(5):480–5. [PMID: 30129509]
  34. Raifman JR, Schwartz SR, Sosnowy CD, et al. Brief report: pre-exposure prophylaxis awareness and use among cisgender women at a sexually transmitted disease clinic. J Acquir Immune Defic Syndr. 2019;80(1):36–9. [PMID: 30531295]
  35. Flash C, Adegboyega O, Yu X, et al. Correlates of linkage to HIV preexposure prophylaxis among HIV-testing clients. J Acquir Immune Defic Syndr. 2018;77(4):365–72. [PMID: 29474256]
  36. Walters SM, Platt J, Anakaraonye A, et al. Considerations for the design of pre-exposure prophylaxis (PrEP) interventions for women: lessons learned from the implementation of a novel prep intervention. AIDS Behav. 2021;25:3987–99. [PMID: 34138377]
  37. Auerbach JD, Kinsky S, Brown G, Charles V. Knowledge, attitudes, and likelihood of pre-exposure prophylaxis (PrEP) use among US women at risk of acquiring HIV. AIDS Patient Care STDS. 2015;29(2):102–10. [PMID: 25513954]
  38. Qin Y, Price C, Rutledge R, Puglisi L, Madden LM, Meyer JP. Women’s decision-making about PrEP for HIV prevention in drug treatment contexts. J Int Assoc Provid AIDS Care. 2020;19:232595821990009. [DOI: 10.1177/2325958219900091]
  39. Bradley E, Forsberg K, Betts JE, et al. Factors affecting pre-exposure prophylaxis implementation for women in the United States: a systematic review. J Womens Health. 2019;28(9):1272–85. [DOI: 10.1089/jwh.2018.7353]
  40. New York City Department of Health and Mental Hygiene. PlaySure network for HIV prevention. Available from: https://www1.nyc.gov/site/doh/providers/resources/playsure-network.page . Accessed 22 Sept 2021.
  41. New York City Department of Health and Mental Hygiene. Health department launches city's firstever campaign promoting HIV prevention medication among women. [press release]. New York City NYC DOHMH [Internet]. 2018; Available from: https://www1.nyc.gov/site/doh/about/press/pr2018/pr017-18.page__;!!NLFGqXoFfo8MMQ!-2bFSLleY-K-jIAkDWv9572s3gWDy4Pnu-9c9CHTRDxhrSHyNEj_L9ZOKD0XkTYOt4nJ3I8$ . Accessed 22 Sept 2021.
  42. Bond KT, Gunn AJ. Perceived advantages and disadvantages of using pre-exposure prophylaxis (PrEP) among sexually active black women: an exploratory study. J Black Sex Relatsh. 2016;3(1):1–24. [PMID: 28725660]
  43. Tekeste M, Hull S, Dovidio JF, et al. Differences in medical mistrust between Black and White women: implications for patient–provider communication about PrEP. AIDS Behav. 2018;23(7):1737–48. [DOI: 10.1007/s10461-018-2283-2]
  44. Calabrese SK, Willie TC, Galvao RW, et al. Current US guidelines for prescribing HIV pre-exposure prophylaxis (PrEP) disqualify many women who are at risk and motivated to use PrEP. J Acquir Immune Defic Syndr. 2019;81(4):395–405. [PMID: 30973543]
  45. Collier KL, Colarossi LG, Sanders K. Raising awareness of pre-exposure prophylaxis (PrEP) among women in New York City: community and provider perspectives. J Health Commun. 2017;22(3):183–9. [PMID: 28248625]

MeSH Term

Anti-HIV Agents
Female
HIV Infections
Hispanic or Latino
Humans
New York City
Pre-Exposure Prophylaxis
Sexual Behavior

Chemicals

Anti-HIV Agents

Word Cloud

Created with Highcharts 10.0.0PrEPwomenHIVLatinaBlackinitiationuptakecisgenderdisproportionatelylowassociatedreceivingamongservicesriskinitiatedsignificantlyPre-exposureCisgenderimpactedUSAlthougheffectivepreventinginfectionpopulationremainsaimstudyexaminesociodemographicbehavioralclinicalpsychosocialfactorsdefinedprescription565enrolledpreventioncoordinationprogramNYCJanuary2017December2019metcriteria26%likelywhiteLatina:297%Black:261%White:163%Other:74%awarenessannualincome < $20000unstablyhousedbenefitsnavigationreportingnon-injectiondruguseand/orrecentsexualrelationshipHIV-positivepartnerrelativelyrateobservedsuggestsneedincreaseaccessparticularlycontinueProphylaxisInitiationAmongWomenReceivingPreventionCareCoordinationServicesNewYorkCityprophylaxis

Similar Articles

Cited By