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Virulence
12, 2022;13 (1): 609-633.

Pathogenicity and virulence of Marburg virus.

Mehedy Hasan Abir, Tanjilur Rahman, Ayan Das, Silvia Naznin Etu, Iqbal Hossain Nafiz, Ahmed Rakib, Saikat Mitra, Talha Bin Emran, Kuldeep Dhama, Ariful Islam, Abolghasem Siyadatpanah, Shafi Mahmud, Bonlgee Kim, Mohammad Mahmudul Hassan
Author Information
  1. Mehedy Hasan Abir: Faculty of Food Science and Technology, Chattogram Veterinary and Animal Sciences University, Chittagong, Bangladesh. ORCID
  2. Tanjilur Rahman: Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, University of Chittagong, Chittagong, Bangladesh. ORCID
  3. Ayan Das: Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, University of Chittagong, Chittagong, Bangladesh. ORCID
  4. Silvia Naznin Etu: Department of Genetic Engineering and Biotechnology, Faculty of Biological Sciences, University of Chittagong, Chittagong, Bangladesh. ORCID
  5. Iqbal Hossain Nafiz: Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, University of Chittagong, Chittagong, Bangladesh. ORCID
  6. Ahmed Rakib: Department of Pharmacy, Faculty of Biological Sciences, University of Chittagong, Chittagong, Bangladesh. ORCID
  7. Saikat Mitra: Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh.
  8. Talha Bin Emran: Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, Bangladesh. ORCID
  9. Kuldeep Dhama: Division of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, India. ORCID
  10. Ariful Islam: EcoHealth Alliance, New York, NY, USA. ORCID
  11. Abolghasem Siyadatpanah: Ferdows School of Paramedical and Health, Birjand University of Medical Sciences, Birjand, Iran.
  12. Shafi Mahmud: Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi, Bangladesh. ORCID
  13. Bonlgee Kim: Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Korea. ORCID
  14. Mohammad Mahmudul Hassan: Queensland Alliance for One Health Sciences, School of Veterinary Sciences, The University of Queensland, Gatton, Australia. ORCID
PMID: 35363588 DOI: 10.1080/21505594.2022.2054760

Abstract

Marburg virus (MARV) has been a major concern since 1967, with two major outbreaks occurring in 1998 and 2004. Infection from MARV results in severe hemorrhagic fever, causing organ dysfunction and death. Exposure to fruit bats in caves and mines, and human-to-human transmission had major roles in the amplification of MARV outbreaks in African countries. The high fatality rate of up to 90% demands the broad study of MARV diseases (MVD) that correspond with MARV infection. Since large outbreaks are rare for MARV, clinical investigations are often inadequate for providing the substantial data necessary to determine the treatment of MARV disease. Therefore, an overall review may contribute to minimizing the limitations associated with future medical research and improve the clinical management of MVD. In this review, we sought to analyze and amalgamate significant information regarding MARV disease epidemics, pathophysiology, and management approaches to provide a better understanding of this deadly virus and the associated infection.

Keywords

Marburg virus cellular tropism epidemiology pathogenicity transmission dynamics virulence

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MeSH Term

Animals
Chiroptera
Disease Models, Animal
Humans
Marburg Virus Disease
Marburgvirus
Virulence
Journal Article Review Research Support, Non-U.S. Gov't
Article has an altmetric score of 136

Word Cloud

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