Joint analysis of multivariate failure time data with latent variables.

Deng Pan, Xinyuan Song, Junhao Pan
Author Information
  1. Deng Pan: School of Mathematics and Statistics, 12443Huazhong University of Science and Technology, Wuhan, China. ORCID
  2. Xinyuan Song: Department of Statistics, 26451The Chinese University of Hong Kong, Hong Kong, China. ORCID
  3. Junhao Pan: Department of Psychology, 26469Sun Yat-sen University, Guangzhou, China.

Abstract

We propose a joint modeling approach to investigate the observed and latent risk factors of the multivariate failure times of interest. The proposed model comprises two parts. The first part is a distribution-free confirmatory factor analysis model that characterizes the latent factors by correlated multiple observed variables. The second part is a multivariate additive hazards model that assesses the observed and latent risk factors of the failure times. A hybrid procedure that combines the borrow-strength estimation approach and the asymptotically distribution-free generalized least square method is developed to estimate the model parameters. The asymptotic properties of the proposed estimators are derived. Simulation studies demonstrate that the proposed method performs well for practical settings. An application to a study concerning the risk factors of multiple diabetic complications is provided.

Keywords

MeSH Term

Factor Analysis, Statistical
Least-Squares Analysis
Models, Statistical
Multivariate Analysis
Proportional Hazards Models
Risk Factors

Word Cloud

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