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Cellular and molecular life sciences : CMLS
May 10, 2022;79 (6): 287.

Regulation of osteoclast-mediated bone resorption by microRNA.

Ling Ji, Xinyi Li, Shushu He, Song Chen
Author Information
  1. Ling Ji: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
  2. Xinyi Li: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
  3. Shushu He: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China. heshushu-03@163.com.
  4. Song Chen: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China. songchen882002@hotmail.com. ORCID
PMID: 35536437 DOI: 10.1007/s00018-022-04298-y

Abstract

Osteoclast-mediated bone resorption is responsible for bone metabolic diseases, negatively impacting people's health and life. It has been demonstrated that microRNA influences the differentiation of osteoclasts by regulating the signaling pathways during osteoclast-mediated bone resorption. So far, the involved mechanisms have not been fully elucidated. This review introduced the pathways involved in osteoclastogenesis and summarized the related microRNAs binding to their specific targets to mediate the downstream pathways in osteoclast-mediated bone resorption. We also discuss the clinical potential of targeting microRNAs to treat osteoclast-mediated bone resorption as well as the challenges of avoiding potential side effects and producing efficient delivery methods.

Keywords

Bone resorption MicroRNA Osteoclast Signaling pathways

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MeSH Term

Bone Resorption
Cell Differentiation
Humans
MicroRNAs
Osteoclasts
Osteogenesis
RANK Ligand

Chemicals

MicroRNAs
RANK Ligand
Journal Article Review

Word Cloud

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