Effect of intra-nasal nitrilotriacetic acid trisodium salt in lowering elevated calcium cations and improving olfactory dysfunction in COVID-19 patients.
Mohamed H Abdelazim, Ahmed H Abdelazim, Wael F Ismaiel, Mahmoud E Alsobky, Ahmed Younes, Abdelgawad M Hadeya, Sherif Ramzy, Mohammed Shahin
Author Information
Mohamed H Abdelazim: Department of Otolaryngology, Faculty of Medicine, Al-Azhar University, Damietta, 34518, Egypt.
Ahmed H Abdelazim: Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, 11751, Egypt. ahmed.hussienabdelazim@hotmail.com. ORCID
Wael F Ismaiel: Department of Otolaryngology, Faculty of Medicine, Al-Azhar University, Damietta, 34518, Egypt.
Mahmoud E Alsobky: Department of Otolaryngology, Faculty of Medicine, Al-Azhar University, Damietta, 34518, Egypt.
Ahmed Younes: Department of Otolaryngology, Faculty of Medicine, Al-Azhar University, Damietta, 34518, Egypt.
Abdelgawad M Hadeya: Department of Otolaryngology, Faculty of Medicine, Al-Azhar University, Damietta, 34518, Egypt.
Sherif Ramzy: Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, 11751, Egypt.
Mohammed Shahin: Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Damanhour University, Beheira, Egypt.
PURPOSE: An association between COVID-19 and olfactory dysfunction has been noted in many patients worldwide. The olfactory adaptation process leads to an increase in intracellular calcium cation levels. Nitrilotriacetic acid trisodium salt has high selective chelation for calcium cations from olfactory mucus. The aim of this work is to test the effect of an intranasal nitrilotriacetic acid trisodium salt to lower the elevated calcium cations in COVID-19 patients with relevant symptoms of olfactory dysfunction. METHODS: Fifty-eight COVID-19 adult patients with relevant symptoms of olfactory dysfunction were enrolled in a prospective randomized controlled trial. They received a nasal spray containing either 0.9% sodium chloride or 2% nitrilotriacetic acid trisodium salt. Olfactory function was assessed before and after treatment using the Sniffin' Sticks test. Quantitative analysis of calcium cation concentration in nasal secretions was performed using a carbon paste ion-selective electrode. RESULTS: After the application of nitrilotriacetic acid trisodium salt compared to sodium chloride, a significant improvement from functional anosmia to healthy normosmia with significant decrease in calcium cation concentration was observed. CONCLUSIONS: Further collaborative research is needed to fully investigate the effect of an intranasal nitrilotriacetic acid trisodium salt in the treatment of olfactory disorders.
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