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Frontiers in neuroscience
2022;16 858717.

Regional Neural Activity Abnormalities and Whole-Brain Functional Connectivity Reorganization in Bulimia Nervosa: Evidence From Resting-State fMRI.

Jia-Ni Wang, Li-Rong Tang, Wei-Hua Li, Xin-Yu Zhang, Xiao Shao, Ping-Ping Wu, Ze-Mei Yang, Guo-Wei Wu, Qian Chen, Zheng Wang, Peng Zhang, Zhan-Jiang Li, Zhenchang Wang
Author Information
  1. Jia-Ni Wang: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  2. Li-Rong Tang: Beijing Anding Hospital, Capital Medical University, Beijing, China.
  3. Wei-Hua Li: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  4. Xin-Yu Zhang: Beijing Anding Hospital, Capital Medical University, Beijing, China.
  5. Xiao Shao: Beijing Anding Hospital, Capital Medical University, Beijing, China.
  6. Ping-Ping Wu: Beijing Anding Hospital, Capital Medical University, Beijing, China.
  7. Ze-Mei Yang: Beijing Anding Hospital, Capital Medical University, Beijing, China.
  8. Guo-Wei Wu: Chinese Institute for Brain Research, Beijing, China.
  9. Qian Chen: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  10. Zheng Wang: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  11. Peng Zhang: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  12. Zhan-Jiang Li: Beijing Anding Hospital, Capital Medical University, Beijing, China.
  13. Zhenchang Wang: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
PMID: 35573287 DOI: 10.3389/fnins.2022.858717

Abstract

The management of eating behavior in bulimia nervosa (BN) patients is a complex process, and BN involves activity in multiple brain regions that integrate internal and external functional information. This functional information integration occurs in brain regions involved in reward, cognition, attention, memory, emotion, smell, taste, vision and so on. Although it has been reported that resting-state brain activity in BN patients is different from that of healthy controls, the neural mechanisms remain unclear and need to be further explored. The fractional amplitude of low-frequency fluctuation (fALFF) analyses are an important data-driven method that can measure the relative contribution of low-frequency fluctuations within a specific frequency band to the whole detectable frequency range. The fALFF is well suited to reveal the strength of interregional cooperation at the single-voxel level to investigate local neuronal activity power. FC is a brain network analysis method based on the level of correlated dynamics between time series, which establishes the connection between two spatial regions of interest (ROIs) with the assistance of linear temporal correlation. Based on the psychological characteristics of patients with BN and the abnormal brain functional activities revealed by previous neuroimaging studies, in this study, we investigated alterations in regional neural activity by applying fALFF analysis and whole-brain functional connectivity (FC) in patients with BN in the resting state and to explore correlations between brain activities and eating behavior. We found that the left insula and bilateral inferior parietal lobule (IPL), as key nodes in the reorganized resting-state neural network, had altered FC with other brain regions associated with reward, emotion, cognition, memory, smell/taste, and vision-related functional processing, which may have influenced restrained eating behavior. These results could provide a further theoretical basis and potential effective targets for neuropsychological treatment in patients with BN.

Keywords

bulimia nervosa cognition eating behavior resting-state fMRI reward

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