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Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
11, 2022;30 (6): 652-664.

Local problems need global solutions: The metabolic needs of regenerating organisms.

Ines C Kübler, Jenny Kretzschmar, Marko Brankatschk, Tatiana Sandoval-Guzmán
Author Information
  1. Ines C Kübler: Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, Germany.
  2. Jenny Kretzschmar: MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK. ORCID
  3. Marko Brankatschk: Department of Molecular, Cell and Developmental Biology, Technische Universität Dresden, Dresden, Germany.
  4. Tatiana Sandoval-Guzmán: Department of Internal Medicine III, Center for Healthy Aging, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. ORCID
PMID: 35596643 DOI: 10.1111/wrr.13029

Abstract

The vast majority of species that belong to the plant or animal kingdom evolved with two main strategies to counter tissue damage-scar formation and regeneration. Whereas scar formation provides a fast and cost-effective repair to exit life-threatening conditions, complete tissue regeneration is time-consuming and requires vast resources to reinstall functionality of affected organs or structures. Local environments in wound healing are widely studied and findings have provided important biomedical applications. Less well understood are organismic physiological parameters and signalling circuits essential to maintain effective tissue repair. Here, we review accumulated evidence that positions the interplay of local and systemic changes in metabolism as essential variables modulating the injury response. We particularly emphasise the role of lipids and lipid-like molecules as significant components long overlooked.

Keywords

insulin lipids metabolism regeneration systemic response

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Grants

  1. MC_UP_1201/23/Medical Research Council
  2. MCUP1201/23/Medical Research Council

MeSH Term

Animals
Wound Healing
Cicatrix
Signal Transduction
Review Journal Article Research Support, Non-U.S. Gov't
Article has an altmetric score of 7

Word Cloud

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