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Frontiers in microbiology
2022;13 862834.

and Activity of Phibilin Against .

Zhongjie Li, Xiaoyuan Jing, Yaping Yuan, Yingbin Shui, Shasha Li, Zhuoran Zhao, Bo Deng, Wenlu Zhang
Author Information
  1. Zhongjie Li: School of Basic Medical Sciences, Henan University of Science and Technology, Luoyang, China.
  2. Xiaoyuan Jing: School of Basic Medical Sciences, Henan University of Science and Technology, Luoyang, China.
  3. Yaping Yuan: School of Basic Medical Sciences, Henan University of Science and Technology, Luoyang, China.
  4. Yingbin Shui: School of Basic Medical Sciences, Henan University of Science and Technology, Luoyang, China.
  5. Shasha Li: School of Basic Medical Sciences, Henan University of Science and Technology, Luoyang, China.
  6. Zhuoran Zhao: School of Basic Medical Sciences, Henan University of Science and Technology, Luoyang, China.
  7. Bo Deng: School of Basic Medical Sciences, Henan University of Science and Technology, Luoyang, China.
  8. Wenlu Zhang: School of Basic Medical Sciences, Henan University of Science and Technology, Luoyang, China.
PMID: 35633688 DOI: 10.3389/fmicb.2022.862834

Abstract

The increase in the occurrence of antifungal-resistant infections necessitates more research to explore alternative effective and safe agents against this fungus. In this work, Phibilin, a new antimicrobial peptide obtained from and used in traditional Chinese medicine, effectively inhibits the growth and activities of , including the clinical resistant strains. Phibilin is a fungicidal antimicrobial peptide that exhibited its antimicrobial effect against mainly by disrupting the membrane and interacting with the DNA of the fungi. In particular, Phibilin induces the necrosis of the ROS-related pathway. Moreover, this antifungal compound inhibited the biofilm formation of by preventing the development of hyphae in a dose-dependent manner. Furthermore, Phibilin and clotrimazole displayed a synergistic effect in inhibiting the growth of the fungi. In the mouse cutaneous infection model, Phibilin significantly inhibited the formation of skin abscesses and decreased the counts of cells in the infected area. Overall, Phibilin is potentially an effective agent against skin infections caused by .

Keywords

Candida albicans antimicrobial peptide fungicidal skin infection traditional Chinese medicine

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