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Scandinavian journal of immunology
Jun 02, 2022; e13195.

The Karolinska KI/K COVID-19 Immune Atlas: An open resource for immunological research and educational purposes.

Hans-Gustaf Ljunggren, Eivind Heggernes Ask, Martin Cornillet, Benedikt Strunz, Puran Chen, Jagadeeswara Rao Muvva, Mira Akber, Marcus Buggert, Benedict J Chambers, Angelica Cuapio, Majda Dzidic, Iva Filipovic, Malin Flodström-Tullberg, Marina Garcia, Jean-Baptiste Gorin, Sara Gredmark-Russ, Laura Hertwig, Jonas Klingström, Efthymia Kokkinou, Egle Kvedaraite, Magda Lourda, Jenny Mjösberg, Christopher Maucourant, Anna Norrby-Teglund, Laura M Palma Medina, Tiphaine Parrot, André Perez-Potti, Andrea Ponzetta, Emma Ringqvist, Olga Rivera-Ballesteros, Olav Rooyackers, Johan K Sandberg, J Tyler Sandberg, Takuya Sekine, Mattias Svensson, Renata Varnaite, David Wullimann, Karolinska KI/K COVID-19 Study Group, Lars I Eriksson, Soo Aleman, Karl-Johan Malmberg, Kristoffer Strålin, Niklas K Björkström
Author Information
  1. Hans-Gustaf Ljunggren: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. ORCID
  2. Eivind Heggernes Ask: Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway. ORCID
  3. Martin Cornillet: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  4. Benedikt Strunz: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  5. Puran Chen: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  6. Jagadeeswara Rao Muvva: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  7. Mira Akber: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  8. Marcus Buggert: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  9. Benedict J Chambers: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. ORCID
  10. Angelica Cuapio: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. ORCID
  11. Majda Dzidic: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  12. Iva Filipovic: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. ORCID
  13. Malin Flodström-Tullberg: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  14. Marina Garcia: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  15. Jean-Baptiste Gorin: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  16. Sara Gredmark-Russ: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  17. Laura Hertwig: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  18. Jonas Klingström: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  19. Efthymia Kokkinou: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  20. Egle Kvedaraite: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  21. Magda Lourda: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  22. Jenny Mjösberg: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  23. Christopher Maucourant: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  24. Anna Norrby-Teglund: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  25. Laura M Palma Medina: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  26. Tiphaine Parrot: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  27. André Perez-Potti: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  28. Andrea Ponzetta: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  29. Emma Ringqvist: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  30. Olga Rivera-Ballesteros: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  31. Olav Rooyackers: Department of Emergency Medicine, Karolinska University Hospital, Stockholm, Sweden.
  32. Johan K Sandberg: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  33. J Tyler Sandberg: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  34. Takuya Sekine: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  35. Mattias Svensson: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. ORCID
  36. Renata Varnaite: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  37. David Wullimann: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  38. Lars I Eriksson: Department of Emergency Medicine, Karolinska University Hospital, Stockholm, Sweden.
  39. Soo Aleman: Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.
  40. Karl-Johan Malmberg: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  41. Kristoffer Strålin: Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.
  42. Niklas K Björkström: Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
PMID: 35652743 DOI: 10.1111/sji.13195

Abstract

The Karolinska KI/K COVID-19 Immune Atlas project was conceptualized in March 2020 as a part of the academic research response to the developing SARS-CoV-2 pandemic. The aim was to rapidly provide a curated dataset covering the acute immune response towards SARS-CoV-2 infection in humans, as it occurred during the first wave. The Immune Atlas was built as an open resource for broad research and educational purposes. It contains a presentation of the response evoked by different immune and inflammatory cells in defined naïve patient-groups as they presented with moderate and severe COVID-19 disease. The present Resource Article describes how the Karolinska KI/K COVID-19 Immune Atlas allow scientists, students, and other interested parties to freely explore the nature of the immune response towards human SARS-CoV-2 infection in an online setting.

Keywords

COVID-19 Karolinska KI/K COVID-19 Immune Atlas SARS-CoV-2 biobank immune atlas immune response

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Journal Article
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