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The Journal of international medical research
Jun, 2022;50 (6): 3000605221106410.

Ureaplasma urealyticum induces polymorphonuclear elastase to change semen properties and reduce sperm motility: a prospective observational study.

Huang Liu, Xiaoyan Song, Mulan Huang, Huashen Zhan, Shiyang Wang, Shenghui Zhu, Tao Pang, Xinzong Zhang, Qingqi Zeng
Author Information
  1. Huang Liu: The First School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China. ORCID
  2. Xiaoyan Song: Department of Clinical Laboratory, NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute (Guangdong Provincial Fertility Hospital), Human Sperm Bank of Guangdong Province, Guangzhou, Guangdong Province, China.
  3. Mulan Huang: Department of Clinical Laboratory, NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute (Guangdong Provincial Fertility Hospital), Human Sperm Bank of Guangdong Province, Guangzhou, Guangdong Province, China.
  4. Huashen Zhan: Reproductive Center, Sanming Integrated Medicine Hospital, Sanming, Fujian Province, China.
  5. Shiyang Wang: Reproductive Center, The Second People's Hospital of Yunnan Province, Kunming, Yunnan Province, China.
  6. Shenghui Zhu: Department of Andrology, NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute (Guangdong Provincial Fertility Hospital), Human Sperm Bank of Guangdong Province, Guangzhou, Guangdong Province, China.
  7. Tao Pang: Department of Andrology, NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute (Guangdong Provincial Fertility Hospital), Human Sperm Bank of Guangdong Province, Guangzhou, Guangdong Province, China.
  8. Xinzong Zhang: Department of Andrology, NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute (Guangdong Provincial Fertility Hospital), Human Sperm Bank of Guangdong Province, Guangzhou, Guangdong Province, China.
  9. Qingqi Zeng: The First School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
PMID: 35701892 DOI: 10.1177/03000605221106410

Abstract

OBJECTIVE: To elucidate the mechanism underlying how (UU) affects sperm quality and identify a therapeutic target.
METHODS: In this prospective observational study, the differences in and relationships among semen volume, pH, viscosity, liquefaction time, sperm concentration, sperm motility [progressive motility (PR)], and seminal polymorphonuclear (PMN) elastase were analyzed in 198 normal semen samples (control group) and 198 UU-infected semen samples (observation group). The UU-infected samples were treated and the above parameters were compared between the two groups.
RESULTS: The semen volume, viscosity, liquefaction time, and seminal PMN elastase were significantly higher in the observation than control group, but the pH and PR were significantly lower. In the observation group, the pH and PR were significantly higher after than before treatment, whereas the semen volume, PMN elastase, viscosity, and liquefaction time were lower. UU was closely related to semen volume, pH, viscosity, liquefaction time, sperm motility (PR), and PMN elastase. PMN elastase had significant negative effects on semen pH and sperm motility (PR) but positive effects on viscosity and liquefaction time.
CONCLUSION: UU might induce PMN elastase to increase the liquefaction time and viscosity of semen, eventually decreasing PR. PMN elastase might be a therapeutic target of UU.

Keywords

Ureaplasma urealyticum observational study polymorphonuclear elastase semen characteristics sperm motility (progressive motility) therapeutic target

References

  1. An Bras Dermatol. 2021 Mar-Apr;96(2):176-183 [PMID: 33640187]
  2. Fertil Steril. 1994 Feb;61(2):341-8 [PMID: 8299794]
  3. Andrologia. 2005 Oct;37(5):188-94 [PMID: 16266398]
  4. Biochemistry. 1987 Apr 21;26(8):2238-42 [PMID: 3650109]
  5. J Androl. 2004 Jan-Feb;25(1):104-9 [PMID: 14662792]
  6. Andrologia. 2003 Aug;35(4):209-16 [PMID: 12950404]
  7. Lett Appl Microbiol. 2021 Oct;73(4):506-514 [PMID: 34089202]
  8. Fertil Steril. 1991 May;55(5):1017-9 [PMID: 2022260]
  9. Front Microbiol. 2021 Nov 03;12:738894 [PMID: 34803955]
  10. Infection. 2018 Feb;46(1):31-38 [PMID: 29124647]
  11. PLoS One. 2013 Dec 02;8(12):e82014 [PMID: 24312623]
  12. Med Wieku Rozwoj. 2006 Jul-Sep;10(3 Pt 2):985-92 [PMID: 17401188]
  13. Wiad Lek. 2021;74(4):896-901 [PMID: 34156000]
  14. Urol Int. 2021;105(3-4):328-333 [PMID: 33264795]
  15. Phys Rev E. 2019 Dec;100(6-1):063107 [PMID: 31962458]
  16. Andrologia. 2008 Oct;40(5):329-34 [PMID: 18811924]
  17. Asian J Androl. 2007 May;9(3):299-304 [PMID: 17486269]
  18. BMC Public Health. 2020 Jun 29;20(1):1020 [PMID: 32600306]
  19. Front Immunol. 2019 Oct 04;10:2373 [PMID: 31636643]
  20. Int J Androl. 2009 Dec;32(6):637-46 [PMID: 18710409]
  21. Anaerobe. 2020 Apr;62:102101 [PMID: 31525453]
  22. Hum Reprod Update. 1998 Nov-Dec;4(6):891-903 [PMID: 10098479]
  23. Andrologia. 2020 Aug;52(7):e13637 [PMID: 32453875]
  24. J Clin Microbiol. 2016 Dec 28;55(1):321-325 [PMID: 27629896]
  25. Biol Reprod. 2007 Sep;77(3):476-84 [PMID: 17567961]
  26. J Infect Chemother. 2021 Oct;27(10):1384-1388 [PMID: 34332883]
  27. Basic Clin Androl. 2018 Jun 4;28:6 [PMID: 29881623]
  28. Ann Intern Med. 2007 Oct 16;147(8):573-7 [PMID: 17938396]
  29. Hum Reprod. 2000 Sep;15(9):1978-84 [PMID: 10966999]
  30. Int J Androl. 2009 Aug;32(4):317-29 [PMID: 18194283]
  31. Semin Cell Dev Biol. 2020 Jan;97:131-137 [PMID: 31254609]
  32. Clin Chim Acta. 2017 Aug;471:286-291 [PMID: 28622967]
  33. J Med Microbiol. 2007 Aug;56(Pt 8):1025-1032 [PMID: 17644708]
  34. Clin Chem Lab Med. 2003 Jan;41(1):2-12 [PMID: 12636042]
  35. Braz J Microbiol. 2021 Dec;52(4):2013-2019 [PMID: 34561845]
  36. J Eur Acad Dermatol Venereol. 2018 Nov;32(11):1845-1851 [PMID: 29924422]

MeSH Term

Humans
Infertility, Male
Leukocyte Elastase
Male
Semen
Sperm Motility
Spermatozoa
Ureaplasma Infections
Ureaplasma urealyticum

Chemicals

Leukocyte Elastase
Journal Article Observational Study

Word Cloud

Created with Highcharts 10.0.0semenelastasespermPMNviscosityliquefactiontimemotilityPRpHUUvolumegrouptherapeutictargetobservationalstudypolymorphonuclearsamplesobservationsignificantlyprospectiveseminal198controlUU-infectedhigherlowereffectsmightUreaplasmaurealyticumOBJECTIVE:elucidatemechanismunderlyingaffectsqualityidentifyMETHODS:differencesrelationshipsamongconcentration[progressive]analyzednormaltreatedparameterscomparedtwogroupsRESULTS:treatmentwhereascloselyrelatedsignificantnegativepositiveCONCLUSION:induceincreaseeventuallydecreasinginduceschangepropertiesreducemotility:characteristicsprogressive

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