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Frontiers in oncology
2022;12 920652.

Role of IQ Motif-Containing GTPase-Activating Proteins in Hepatocellular Carcinoma.

Qingqing Dai, Quratul Ain, Michael Rooney, Fei Song, Alexander Zipprich
Author Information
  1. Qingqing Dai: Department of Internal Medicine IV (Gastroenterology, Hepatology, and Infectious Diseases), Jena University Hospital, Jena, Germany.
  2. Quratul Ain: Department of Internal Medicine IV (Gastroenterology, Hepatology, and Infectious Diseases), Jena University Hospital, Jena, Germany.
  3. Michael Rooney: Department of Internal Medicine IV (Gastroenterology, Hepatology, and Infectious Diseases), Jena University Hospital, Jena, Germany.
  4. Fei Song: Department of Urology, Jena University Hospital, Jena, Germany.
  5. Alexander Zipprich: Department of Internal Medicine IV (Gastroenterology, Hepatology, and Infectious Diseases), Jena University Hospital, Jena, Germany.
PMID: 35785216 DOI: 10.3389/fonc.2022.920652

Abstract

IQ motif-containing GTPase-activating proteins (IQGAPs) are a class of scaffolding proteins, including IQGAP1, IQGAP2, and IQGAP3, which govern multiple cellular activities by facilitating cytoskeletal remodeling and cellular signal transduction. The role of IQGAPs in cancer initiation and progression has received increasing attention in recent years, especially in hepatocellular carcinoma (HCC), where the aberrant expression of IQGAPs is closely related to patient prognosis. IQGAP1 and 3 are upregulated and are considered oncogenes in HCC, while IQGAP2 is downregulated and functions as a tumor suppressor. This review details the three IQGAP isoforms and their respective structures. The expression and role of each protein in different liver diseases and mainly in HCC, as well as the underlying mechanisms, are also presented. This review also provides a reference for further studies on IQGAPs in HCC.

Keywords

HBV IQGAPs cytoskeleton hepatocellular carcinoma signal transduction

References

  1. Autophagy. 2021 Dec;17(12):4423-4441 [PMID: 33866937]
  2. J Hepatol. 2009 Jun;50(6):1174-83 [PMID: 19398237]
  3. Mod Pathol. 2008 May;21(5):505-16 [PMID: 18277965]
  4. PLoS One. 2013 Aug 12;8(8):e71826 [PMID: 23951254]
  5. Mol Cell Biol. 2021 Mar 24;41(4): [PMID: 33526450]
  6. Dev Cell. 2004 Dec;7(6):871-83 [PMID: 15572129]
  7. J Biol Chem. 2009 May 29;284(22):14857-65 [PMID: 19321438]
  8. FEBS Lett. 2009 Jun 18;583(12):1817-24 [PMID: 19433088]
  9. Biochim Biophys Acta Gen Subj. 2021 Nov;1865(11):129969 [PMID: 34352343]
  10. Asian Pac J Cancer Prev. 2022 Jan 01;23(1):271-279 [PMID: 35092397]
  11. Mol Cancer. 2021 Dec 6;20(1):160 [PMID: 34872584]
  12. Dev Cell. 2019 Feb 25;48(4):460-474.e9 [PMID: 30745141]
  13. Nature. 2017 Jul 6;547(7661):109-113 [PMID: 28658205]
  14. Nat Rev Nephrol. 2021 Mar;17(3):172-184 [PMID: 32989282]
  15. Eur J Cell Biol. 2014 Oct;93(10-12):438-44 [PMID: 25113547]
  16. Biochem Biophys Res Commun. 2021 Jan 1;534:1026-1032 [PMID: 33131769]
  17. J Biol Chem. 1994 Aug 12;269(32):20517-21 [PMID: 8051149]
  18. Mol Cell Biol. 1996 Sep;16(9):4869-78 [PMID: 8756646]
  19. Br J Cancer. 2020 Sep;123(7):1154-1163 [PMID: 32632148]
  20. Metabolomics. 2014 Oct 1;10(5):920-937 [PMID: 25254002]
  21. Asian Pac J Cancer Prev. 2014;15(12):4951-6 [PMID: 24998570]
  22. Biomed Pharmacother. 2021 Mar;135:111243 [PMID: 33434854]
  23. J Biol Chem. 2017 Feb 24;292(8):3273-3289 [PMID: 28082684]
  24. Science. 1998 Aug 7;281(5378):832-5 [PMID: 9694656]
  25. Mol Cancer Res. 2022 Jan;20(1):77-91 [PMID: 34615693]
  26. Hepatology. 2016 Jul;64(1):73-84 [PMID: 26707365]
  27. Int Immunopharmacol. 2021 Jun;95:107520 [PMID: 33743313]
  28. Elife. 2021 Jul 16;10: [PMID: 34269679]
  29. Oncol Lett. 2020 Aug;20(2):1179-1192 [PMID: 32724358]
  30. Mol Cell Biol. 2008 Mar;28(5):1489-502 [PMID: 18180285]
  31. Int J Mol Sci. 2021 Nov 22;22(22): [PMID: 34830479]
  32. Mol Oncol. 2021 Nov;15(11):3062-3075 [PMID: 33793053]
  33. J Biol Chem. 2017 May 26;292(21):8750-8761 [PMID: 28396345]
  34. Front Pharmacol. 2021 Jan 14;11:584450 [PMID: 33519444]
  35. J Transl Med. 2017 Aug 15;15(1):176 [PMID: 28810875]
  36. Gut. 2021 Oct;70(10):1833-1846 [PMID: 33293280]
  37. Clin Gastroenterol Hepatol. 2011 Jan;9(1):64-70 [PMID: 20831903]
  38. Cancers (Basel). 2021 Aug 04;13(16): [PMID: 34439095]
  39. J Cell Physiol. 2021 Feb;236(2):1270-1280 [PMID: 32643295]
  40. CA Cancer J Clin. 2021 May;71(3):209-249 [PMID: 33538338]
  41. J Exp Clin Cancer Res. 2020 Aug 3;39(1):148 [PMID: 32746865]
  42. Int J Mol Sci. 2017 Mar 08;18(3): [PMID: 28282856]
  43. Mol Ther Nucleic Acids. 2021 Dec 17;27:471-483 [PMID: 35036058]
  44. Small GTPases. 2020 Jan;11(1):16-22 [PMID: 28622072]
  45. EMBO Rep. 2015 Apr;16(4):427-46 [PMID: 25722290]
  46. Nature. 2001 May 17;411(6835):355-65 [PMID: 11357143]
  47. Mol Biol Cell. 2022 Jan 1;33(1):ar2 [PMID: 34731043]
  48. Clin Transl Med. 2021 Mar;11(3):e352 [PMID: 33783988]
  49. Am Soc Clin Oncol Educ Book. 2018 May 23;38:262-279 [PMID: 30231359]
  50. J Cell Biol. 1994 Jul;126(2):391-401 [PMID: 7518464]
  51. Int J Med Sci. 2021 Apr 22;18(12):2466-2479 [PMID: 34104078]
  52. Pharmacol Res. 2020 Sep;159:104992 [PMID: 32505833]
  53. J Cell Biol. 2008 Jun 16;181(6):985-98 [PMID: 18541705]
  54. J Biol Chem. 2016 Dec 16;291(51):26364-26376 [PMID: 27815503]
  55. Front Pharmacol. 2021 May 06;12:671640 [PMID: 34025430]
  56. Int J Mol Sci. 2021 Aug 17;22(16): [PMID: 34445559]
  57. Biochem Biophys Res Commun. 2017 Dec 2;493(4):1384-1389 [PMID: 28970065]
  58. J Biol Chem. 2007 Jul 13;282(28):20752-62 [PMID: 17517894]
  59. Cancers (Basel). 2021 May 10;13(9): [PMID: 34068608]
  60. Environ Toxicol. 2020 Feb;35(2):167-175 [PMID: 31714653]
  61. Structure. 2016 Sep 6;24(9):1499-508 [PMID: 27524202]
  62. Nature. 1991 May 23;351(6324):317-20 [PMID: 2034275]
  63. Nat Rev Cancer. 2002 Feb;2(2):133-42 [PMID: 12635176]
  64. World J Gastroenterol. 2022 Jan 7;28(1):76-95 [PMID: 35125820]
  65. Phytother Res. 2022 Jan;36(1):525-542 [PMID: 34847624]
  66. Biomed Pharmacother. 2021 Jul;139:111657 [PMID: 34243626]
  67. Front Cell Dev Biol. 2021 Sep 21;9:730176 [PMID: 34621747]
  68. J Invest Dermatol. 2015 Sep;135(9):2258-2265 [PMID: 25848980]
  69. Tumour Biol. 2016 Oct;37(10):13927-13939 [PMID: 27488117]
  70. J Immunol. 2017 Oct 15;199(8):2896-2909 [PMID: 28864474]
  71. Cell Death Dis. 2021 Apr 12;12(4):389 [PMID: 33846302]
  72. Cells. 2021 Feb 23;10(2): [PMID: 33672268]
  73. J Clin Invest. 2005 Feb;115(2):209-18 [PMID: 15690074]
  74. Am J Cancer Res. 2019 Feb 01;9(2):285-299 [PMID: 30906629]
  75. Nat Med. 2013 May;19(5):626-630 [PMID: 23603816]
  76. Science. 1996 Dec 20;274(5295):2115-8 [PMID: 8953049]
  77. Exp Mol Med. 2010 Jul 31;42(7):477-83 [PMID: 20530982]
  78. Hepatology. 2021 May;73(5):1717-1735 [PMID: 33682185]
  79. PLoS One. 2013;8(2):e56574 [PMID: 23441206]
  80. J Cell Physiol. 2009 Sep;220(3):621-31 [PMID: 19452445]
  81. Mol Cell Proteomics. 2006 Jul;5(7):1300-13 [PMID: 16622255]
  82. J Biol Chem. 2012 Nov 2;287(45):38367-78 [PMID: 22992742]
  83. Onco Targets Ther. 2020 Aug 20;13:8299-8311 [PMID: 32903879]
  84. J Biol Chem. 2017 Sep 8;292(36):14989-15001 [PMID: 28739799]
  85. Acta Pharm Sin B. 2021 Sep;11(9):2819-2834 [PMID: 34589399]
  86. Mol Immunol. 2015 Jun;65(2):336-49 [PMID: 25733387]
  87. Foods. 2021 Aug 29;10(9): [PMID: 34574146]
  88. J Biol Chem. 2018 Mar 9;293(10):3685-3699 [PMID: 29358323]
  89. J Hepatol. 2016 Nov;65(5):972-979 [PMID: 27401546]
  90. J Biol Chem. 2005 Apr 8;280(14):13871-8 [PMID: 15695813]
  91. J Biol Chem. 2002 Jul 5;277(27):24753-63 [PMID: 11948177]
  92. Transl Gastroenterol Hepatol. 2019 May 17;4:33 [PMID: 31231700]
  93. J Hematol Oncol. 2021 Apr 6;14(1):55 [PMID: 33823905]
  94. Cancer Cell Int. 2016 Jul 07;16:55 [PMID: 27390551]
  95. Int J Cardiol. 2022 Jan 1;346:62-70 [PMID: 34774887]
  96. Mol Cancer Res. 2021 Oct;19(10):1712-1726 [PMID: 34183451]
  97. Int J Clin Exp Pathol. 2015 Aug 01;8(8):8821-31 [PMID: 26464624]
  98. Cell Struct Funct. 2015;40(2):69-77 [PMID: 26051604]
  99. Proteomics Clin Appl. 2009 Mar;3(3):307-21 [PMID: 26238749]
  100. Biophys J. 2020 Feb 4;118(3):586-599 [PMID: 31952801]
  101. Gastroenterology Res. 2021 Jun;14(3):139-156 [PMID: 34267829]
  102. Regul Pept. 2012 Jan 10;173(1-3):36-46 [PMID: 21968151]
  103. Oncotarget. 2021 Nov 23;12(24):2421-2433 [PMID: 34853663]
  104. Cancer Lett. 2020 Nov 28;493:254-265 [PMID: 32896617]
  105. Nat Rev Gastroenterol Hepatol. 2019 Feb;16(2):121-136 [PMID: 30451972]
  106. PLoS One. 2015 Aug 07;10(8):e0133770 [PMID: 26252773]
  107. Genes Cells. 2014 Nov;19(11):803-20 [PMID: 25229330]
  108. Semin Cancer Biol. 2021 Jun 25;: [PMID: 34175443]
  109. J Biol Chem. 2004 Apr 23;279(17):17329-37 [PMID: 14970219]
  110. Cancer Treat Res Commun. 2022;31:100511 [PMID: 35030478]
  111. World J Biol Chem. 2012 Mar 26;3(3):53-60 [PMID: 22451851]
  112. JCI Insight. 2018 Nov 2;3(21): [PMID: 30385723]
  113. Int J Biol Markers. 2019 Dec;34(4):348-355 [PMID: 31544570]
  114. Immune Netw. 2021 Oct 26;21(5):e37 [PMID: 34796041]
  115. Cell. 2002 Jun 28;109(7):873-85 [PMID: 12110184]
  116. J Biol Chem. 2011 Apr 29;286(17):15010-21 [PMID: 21349850]
  117. Nature. 2021 Jul;595(7869):730-734 [PMID: 34290403]
  118. Biochemistry. 2019 Dec 10;58(49):4903-4911 [PMID: 31724397]
  119. J Biol Chem. 2011 Aug 26;286(34):29734-47 [PMID: 21724847]
  120. J Biol Chem. 2020 Apr 10;295(15):4822-4835 [PMID: 32094223]
  121. Trends Biochem Sci. 2021 Jan;46(1):51-63 [PMID: 32928629]
  122. Cancer Lett. 2021 Jun 1;507:112-123 [PMID: 33737002]
  123. J Proteome Res. 2014 Feb 7;13(2):1156-66 [PMID: 24294828]
  124. J Pathol. 2015 Apr;235(5):784-95 [PMID: 25430888]
  125. Cells. 2021 Jul 20;10(7): [PMID: 34359999]
  126. Biochim Biophys Acta Mol Cell Res. 2022 Apr;1869(4):119201 [PMID: 35026349]
  127. J Biol Chem. 2013 Aug 2;288(31):22378-86 [PMID: 23788642]
  128. Nat Cell Biol. 2018 Sep;20(9):1064-1073 [PMID: 30104724]
  129. Nat Rev Dis Primers. 2021 Jan 21;7(1):6 [PMID: 33479224]
  130. Cell Rep. 2013 Nov 27;5(4):1060-9 [PMID: 24268772]
  131. Nat Cell Biol. 2008 Aug;10(8):971-8 [PMID: 18604197]
  132. J Cell Sci. 2007 Feb 15;120(Pt 4):567-77 [PMID: 17244649]
  133. Am J Physiol Cell Physiol. 2021 Jun 1;320(6):C987-C999 [PMID: 33881936]
  134. BMC Gastroenterol. 2010 Oct 26;10:125 [PMID: 20977743]
  135. J Clin Invest. 2013 Mar;123(3):1138-56 [PMID: 23454766]
  136. Nat Commun. 2018 Nov 16;9(1):4834 [PMID: 30446657]
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Created with Highcharts 10.0.0IQGAPsHCCIQproteinsIQGAP1IQGAP2cellularsignaltransductionrolehepatocellularcarcinomaexpressionreviewalsomotif-containingGTPase-activatingclassscaffoldingincludingIQGAP3governmultipleactivitiesfacilitatingcytoskeletalremodelingcancerinitiationprogressionreceivedincreasingattentionrecentyearsespeciallyaberrantcloselyrelatedpatientprognosis3upregulatedconsideredoncogenesdownregulatedfunctionstumorsuppressordetailsthreeIQGAPisoformsrespectivestructuresproteindifferentliverdiseasesmainlywellunderlyingmechanismspresentedprovidesreferencestudiesRoleMotif-ContainingGTPase-ActivatingProteinsHepatocellularCarcinomaHBVcytoskeleton

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