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Nov, 2022;390 (2): 141-172.

Epigenetics as "conductor" in "orchestra" of pluripotent states.

Ishita Baral, Pallavi Chinnu Varghese, Debasree Dutta
Author Information
  1. Ishita Baral: Regenerative Biology Program, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, 695014, Kerala, India.
  2. Pallavi Chinnu Varghese: Regenerative Biology Program, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, 695014, Kerala, India.
  3. Debasree Dutta: Regenerative Biology Program, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, 695014, Kerala, India. debasreedutta@rgcb.res.in. ORCID
PMID: 35838826 DOI: 10.1007/s00441-022-03667-0

Abstract

Pluripotent character is described as the potency of cells to differentiate into all three germ layers. The best example to reinstate the term lies in the context of embryonic stem cells (ESCs). Pluripotent ESC describes the in vitro status of those cells that originate during the complex process of embryogenesis. Pre-implantation to post-implantation development of embryo embrace cells with different levels of stemness. Currently, four states of pluripotency have been recognized, in the progressing order of "naïve," "poised," "formative," and "primed." Epigenetics act as the "conductor" in this "orchestra" of transition in pluripotent states. With a distinguishable gene expression profile, these four states associate with different epigenetic signatures, sometimes distinct while otherwise overlapping. The present review focuses on how epigenetic factors, including DNA methylation, bivalent chromatin, chromatin remodelers, chromatin/nuclear architecture, and microRNA, could dictate pluripotent states and their transition among themselves.

Keywords

Epigenetics Formative Naïve Pluripotent states Poised Primed

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Grants

  1. BT/PR17597/MED/31/335/2016/Department of Biotechnology , Ministry of Science and Technology
  2. BT/HRD/NWBA/38/10/2018/Department of Biotechnology , Ministry of Science and Technology
  3. DBT/2020/RGCB/1331/Department of Biotechnology , Ministry of Science and Technology
  4. IF170833/Department of Science and Technology, Ministry of Science and Technology

MeSH Term

Pluripotent Stem Cells
Epigenesis, Genetic
Germ Layers
Embryonic Stem Cells
Chromatin
Cell Differentiation

Chemicals

Chromatin
Journal Article Review
Article has an altmetric score of 3

Word Cloud

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