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International journal of clinical practice
2022;2022 9619699.

Characteristics of Pharmacists' Interventions Related to Proton-Pump Inhibitors in French Hospitals: An Observational Study.

A L Yailian, E Huet, B Charpiat, O Conort, M Juste, R Roubille, M Bourdelin, J Gravoulet, C Mongaret, C Vermorel, P Bedouch, A Janoly-Duménil
Author Information
  1. A L Yailian: Pharmacy Department, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.
  2. E Huet: Pharmacy Department, Dieppe Hospital, Dieppe, France.
  3. B Charpiat: Pharmacy Department, Croix Rousse Hospital, Hospices Civils de Lyon, Lyon 69004, France.
  4. O Conort: Working Group 'Valorization of Pharmaceutical Interventions/Valorisation des Interventions Pharmaceutiques - Act-IP©' of the French Society for Clinical Pharmacy, Marseille, France.
  5. M Juste: Working Group 'Valorization of Pharmaceutical Interventions/Valorisation des Interventions Pharmaceutiques - Act-IP©' of the French Society for Clinical Pharmacy, Marseille, France.
  6. R Roubille: Pharmacy Department, Lucien Hussel Hospital, Vienne, France.
  7. M Bourdelin: Working Group 'Valorization of Pharmaceutical Interventions/Valorisation des Interventions Pharmaceutiques - Act-IP©' of the French Society for Clinical Pharmacy, Marseille, France.
  8. J Gravoulet: Working Group 'Valorization of Pharmaceutical Interventions/Valorisation des Interventions Pharmaceutiques - Act-IP©' of the French Society for Clinical Pharmacy, Marseille, France.
  9. C Mongaret: Working Group 'Valorization of Pharmaceutical Interventions/Valorisation des Interventions Pharmaceutiques - Act-IP©' of the French Society for Clinical Pharmacy, Marseille, France.
  10. C Vermorel: Université Grenoble Alpes, CNRS/TIMC UMR5525, F-38041, Grenoble, France.
  11. P Bedouch: Université Grenoble Alpes, CNRS/TIMC UMR5525, F-38041, Grenoble, France.
  12. A Janoly-Duménil: Pharmacy Department, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France. ORCID
PMID: 35846437 DOI: 10.1155/2022/9619699

Abstract

Methods: The study was based on a retrospective analysis of pharmacist interventions for DRPs detected during the medication order review and documented into the French Act-IP© database over a 12-year period. DRPs and PIs were analyzed, and independent factors of physician acceptance were assessed via multiple logistic regression.
Results: Out of the 620,620 PIs registered, 29,694 targeted a PPI (4.8%). PPI's DRPs were mostly related to the prescription of a "drug not available at the hospital" (26.1%) and a "drug use without indication" (18.3%); PIs were mostly "drug switch" (35.9%) and "drug discontinuation" (26.1%). In all, 18,919 PIs were accepted by physicians (63.7%). Acceptance was significantly associated with patient age: less accepted for the 18-75 years group (OR = 0.59, 95 CI [0.46-0.76]), and the >75 years group (OR = 0.57, 95 CI [0.44-0.73]) vs. <18 years group; for the type of DRP, "drug use without indication" was the less accepted (OR = 0.73, 95 CI [0.63-0.85]); for the type of PI, "dose adjustment" was the less accepted (OR = 0.32, 95 CI [0.23-0.45]).
Conclusion: Pharmacists contribute to preventing DRPs associated with PPI prescriptions during the medication order review process. Moreover, they often detect PPIs used without indication and they propose drug discontinuation, which contributes to the PPI deprescribing process. PIs should be further developed in the future to reduce PPI overprescription.

References

  1. Can Fam Physician. 2017 May;63(5):354-364 [PMID: 28500192]
  2. Drugs Aging. 2012 Aug 1;29(8):681-90 [PMID: 22775478]
  3. Soc Sci Med. 1997 Nov;45(10):1571-9 [PMID: 9351147]
  4. Dig Dis Sci. 2013 Mar;58(3):777-81 [PMID: 23065088]
  5. Can Pharm J (Ott). 2018 Dec 17;152(1):18-22 [PMID: 30719193]
  6. J Am Med Dir Assoc. 2016 Jul 1;17(7):673.e1-4 [PMID: 27289201]
  7. Eur J Intern Med. 2017 Jan;37:19-24 [PMID: 27784575]
  8. Ther Adv Drug Saf. 2018 Oct 20;9(12):687-698 [PMID: 30546863]
  9. Pharm World Sci. 2006 Aug;28(4):181-8 [PMID: 17066245]
  10. Saudi J Gastroenterol. 2010 Oct-Dec;16(4):275-9 [PMID: 20871193]
  11. Eur J Hosp Pharm. 2016 Jul;23(4):207-212 [PMID: 31156850]
  12. Int J Clin Pract. 2012 Jun;66(6):582-91 [PMID: 22607510]
  13. Eur J Hosp Pharm. 2016 May;23(3):177-181 [PMID: 31156842]
  14. Br J Clin Pharmacol. 2004 Apr;57(4):513-21 [PMID: 15025751]
  15. J Manag Care Pharm. 2010 Mar;16(2):122-9 [PMID: 20178397]
  16. Aliment Pharmacol Ther. 2021 Jul;54(2):129-143 [PMID: 34114655]
  17. Implement Sci. 2019 Jun 6;14(1):55 [PMID: 31171011]
  18. J Clin Pharm Ther. 2015 Feb;40(1):32-40 [PMID: 25303720]
  19. BMC Med. 2016 Nov 9;14(1):179 [PMID: 27825371]
  20. Qual Saf Health Care. 2009 Jun;18(3):232-5 [PMID: 19468008]
  21. Am J Gastroenterol. 2009 Mar;104 Suppl 2:S27-32 [PMID: 19262544]
  22. Presse Med. 2013 Feb;42(2):e53-62 [PMID: 23237784]
  23. Ann Pharmacother. 2008 Jul;42(7):1095-103 [PMID: 18559955]
  24. Aliment Pharmacol Ther. 2020 Jan;51(1):121-128 [PMID: 31664732]
  25. Eur J Clin Pharmacol. 2019 Sep;75(9):1327-1329 [PMID: 31129732]
  26. J Pharm Belg. 2015 Jun;(2):20-9 [PMID: 26466506]
  27. Therap Adv Gastroenterol. 2012 Jul;5(4):219-32 [PMID: 22778788]
  28. BMJ. 2008 Jan 5;336(7634):2-3 [PMID: 18174564]
  29. Can J Hosp Pharm. 2018 Jul-Aug;71(4):267-271 [PMID: 30186000]
  30. J Hosp Med. 2015 May;10(5):281-6 [PMID: 25708942]
  31. Rev Med Interne. 2021 Aug;42(8):535-540 [PMID: 33323294]

MeSH Term

Adolescent
Adult
Aged
Drug-Related Side Effects and Adverse Reactions
Hospitals
Humans
Medication Errors
Middle Aged
Pharmacists
Pharmacy Service, Hospital
Proton Pump Inhibitors
Retrospective Studies
Young Adult

Chemicals

Proton Pump Inhibitors
Journal Article Observational Study

Word Cloud

Created with Highcharts 10.0.0PIs"drugDRPsPPIacceptedOR = 095CI[0withoutlessyearsgroupmedicationorderreviewFrench620mostly261%useindication"18associatedtypeprocessMethods:studybasedretrospectiveanalysispharmacistinterventionsdetecteddocumentedAct-IP©database12-yearperiodanalyzedindependentfactorsphysicianacceptanceassessedviamultiplelogisticregressionResults:registered29694targeted48%PPI'srelatedprescriptionavailablehospital"3%switch"359%discontinuation"919physicians637%Acceptancesignificantlypatientage:18-755946-076]>755744-073]vs<18DRP7363-085]PI"doseadjustment"3223-045]Conclusion:PharmacistscontributepreventingprescriptionsMoreoveroftendetectPPIsusedindicationproposedrugdiscontinuationcontributesdeprescribingdevelopedfuturereduceoverprescriptionCharacteristicsPharmacists'InterventionsRelatedProton-PumpInhibitorsHospitals:ObservationalStudy

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