Efficacy and safety of different modes of exercise-based cardiac rehabilitation delivery for patients with heart failure: a protocol for a systematic review and network meta-analysis.
Lingjun Jiang, Ruixuan Wan, Bohan Li, XuHui Huang, Yaning Xu, Kaisong Wu, Jie Xu, Yan Lu
Author Information
Lingjun Jiang: Department of Sports and Rehabilitation Medicine, Ulm University Hospital, Ulm, Germany.
Ruixuan Wan: Department of Chemistry, University of Washington, Seattle, Washington State, USA.
Bohan Li: Department of Minimally Invasive Gynecologic Center, Capital Medical University, Beijing, China.
XuHui Huang: Department of Breast Surgery, Baoding First Central Hospital, Baoding, China.
Yaning Xu: Department of Pediatrics, Wangdu County Hospital, Baoding, China.
Kaisong Wu: Department of Pediatrics, The No.2 Hospital of Baoding, Baoding, China.
Jie Xu: Department of Ophthalmology, The Hospital of Yutian County, Tangshan, China.
Yan Lu: Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China luyan_cpu@163.com. ORCID
INTRODUCTION: The prevalence of heart failure (HF) is increasing. Exercise-based cardiac rehabilitation (CR) reduces mortality and further improves the prognosis of patients with HF. However, the effect of different modes of CR delivery on HF remains unclear. Thus, the purpose of this study is to find out the relative efficacy and safety of different modes of CR delivery for individuals with HF using a network meta-analysis. METHODS AND ANALYSIS: We will perform a systematic review and network meta-analysis of randomised controlled trials which compare different modes of exercise-based CR delivery for patients with HF. Databases including Embase, Medline, the Cochrane Central Register of Controlled Trials and Web of Science will be searched up to May 2022. The primary outcomes will focus on the functional capacity and the health-related quality of life (hr-QOL). Functional capacity will be evaluated by peak oxygen consumption (mL/kg/min) and 6 min walking test (metres). The Minnesota Living with Heart Failure questionnaire, Short Form-36, Psychometric properties of the Kansas City cardiomyopathy questionnaire and EuroQol five dimensions questionnaire will serve as measures of hr-QOL. As secondary outcomes, we will assess hospital admissions (all-cause and cardiac) and all-cause mortality, which required a minimum follow-up of 6 months, as well as adverse events during exercise training. The risk of bias for individual studies will be evaluated according to the Cochrane Handbook. The quality of evidence will be assessed by the Grading of Recommendations, Assessment, Development and Evaluation approach. ETHICS AND DISSEMINATION: This study does not require ethics approval as it is based on published trials. Results of this systematic review and network meta-analysis will be submitted to a peer-reviewed journal for future publication. TRIAL REGISTRATION NUMBER: CRD42021278351.
